Results 31 to 40 of about 2,034 (122)
Neurodevelopmental toxicity and Parkinsonism-like symptoms induced by nano-alumina exposure in zebrafish [PDF]
BackgroundNano-alumina (nano-Al2O3) is a widely utilized nanomaterial. Its impacts on the environment and biological systems have garnered significant attention.
Fanzhao ZENG +4 more
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Research progress on the pathogenesis of acute lung injury in sepsis [PDF]
Sepsis is a systemic inflammatory response syndrome caused by severe infection leading to host dysfunction，often involving multiple organs and causing functional failure.
WANG Qin，YU Xu，LI Qingying，LU Yibin
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The latest research progress on P53 and tumor metabolism [PDF]
, 2023 P53 is a key factor encoded by the TP53, and it prevents cells from becoming cancerous and has a wide range of powerful functions. p53 is found to play an important role in inducing DNA repair, apoptosis, cell cycle arrest and senescence, and the loss of
ZHAI Haihui, LIU Yuanqi, ZHANG Congzheng, GUAN Liping, HAN Tao
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Zhongguo cuzhong zazhi急性缺血性卒中后，脑缺血再灌注损伤（cerebral ischemia-reperfusion injury，CIRI）可进一步损伤患者的神经功能，影响其预后。自噬在CIRI的病理过程中是一把“双刃剑”，其不同的激活程度以及在CIRI的不同时期，可对脑组织产生保护或损伤的相反作用。环鸟苷酸-腺苷酸合酶（cyclic guanosine monophosphate-adenosine monophosphate synthase，cGAS）-干扰素基因刺激因子（stimulator of ...
杨航1，高安邦2，倪莹2，马跃1，高名同2 (YANG Hang1, GAO Anbang2, NI Ying2, MA Yue1, GAO Mingtong2 )
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Research Progress in Mitochondrial Treatment and Mechanism in Occurrence of Lung Cancer [PDF]
Lung cancer is characterized by high incidence and mortality rates and invasiveness, and its occurrence and development are influenced by various factors.
CHEN Hui +5 more
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Regulation of Autophagy by DUB-X via Destabilizing p62/SQSTM1 [PDF]
, 2017 自噬是细胞在营养匮乏条件下，降解细胞内成分以维持细胞必要活动与生命 的一种重要生命进程。自噬对维持生物体正常的生命活动具有重要意义。线粒体 自噬是一种选择性的细胞自噬，可以将功能紊乱的线粒体通过自噬途径降解。线 粒体自噬代表了线粒体质量控制的一种方式，对维持最佳的线粒体生物能学水平 起到重要作用。p62是由SQSTM1基因编码的一种蛋白，在细胞的选择性自噬过程中发挥重要的作用。去泛素化酶DUB是细胞内一种重要的具有催化活性的酶，它可以将被泛素化修饰的蛋白去除泛素链 ...
侯晓楠
core
Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨线粒体未折叠蛋白反应（UPR mt ）对阿尔茨海默病（AD）Aβ蛋白聚集毒性的影响。【方法】将秀丽线 虫（Caenorhabditis elegans）线粒体外膜tomm-22、内膜E04A4.5以及atfs-1基因克隆并构建L4440干扰载体，转化HT115感受 态细胞以制备 tomm-22、E04A4.5 和 atfs-1 RNA 干扰菌。研究 tomm-22 和 E04A4.5 RNA 干扰对转基因线虫 AD 疾病模型 CL4176和CL2006瘫痪进程的影响。观察tomm ...
赵思旭 +3 more
doaj
浙江大学学报. 医学版研究证实多种金属污染物暴露可诱导神经毒性，并与神经系统相关疾病的发生发展密切相关。铁死亡是细胞响应金属污染物暴露的细胞死亡方式，其与氧化应激、铁代谢、脂质过氧化等密切相关。近年研究发现，在铅、镉、锰、镍和锑等金属诱导的神经毒性中铁死亡发挥重要作用，如铅暴露通过氧化应激、铁代谢紊乱和炎症触发铁死亡；镉可通过铁离子代谢、氧化应激以及铁死亡相关信号通路引发铁死亡；锰可通过线粒体功能障碍、铁代谢紊乱和氧化应激促进铁死亡；镍可通过氧化应激影响线粒体功能以及破坏铁稳态并促进其中枢神经系统的脂质过氧化，激活铁死亡 ...
秦 子玉 +3 more
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Zhongguo shiyan zhenduanxue, 2015 目的通过饥饿诱导人神经胶质瘤细胞发生自噬,利用siRNA技术部分沉默细胞内氯通道蛋白4（CLIC4）,探讨CLIC4在细胞自噬中的作用。方法根据CLIC4的基因序列构建CLIC4siRNA质粒,建立稳定转染CLIC4siRNA的U251细胞株,分析CLIC4蛋白表达;MTT法检测转染pSH1Si-CLIC4对细胞生存率的影响;利用Western Blot检测转染CLIC4siRNA在U251细胞凋亡相关蛋白Bax、Bcl-2表达;检测饥饿条件下U251细胞LC3蛋白、Bax、Bcl-2的表达 ...
袁兆新 +4 more
doaj
浙江大学学报. 农业与生命科学版In recent years, in vitro embryo production technology for mammals has developed rapidly, providing solutions for the preservation and efficient utilization of mammalian genetic resources with superior traits and local characteristics.
WANG Yuqing(王雨晴) +3 more
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