Results 31 to 40 of about 7,850 (117)

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang   +7 more
wiley   +1 more source

线粒体蛋白转运系统的序列相似性分析

open access: yes四川大学学报. 自然科学版, 2015
通过在27个不同进化层次物种的基因组和蛋白组中搜索酵母线粒体蛋白转运系统亚基的同源序列,并进一步分析了同源亚基序列相似性与其所在线粒体位置的关系.结果表明,位于线粒体相同位置的模块有类似的序列相似性曲线,相似性曲线在模块内部一般有波峰和波谷.从线粒体外膜到基质,序列相似性整体升高.线粒体蛋白转运系统亚基与一些功能不相关的蛋白也表现出序列相似关系,且这些亚基多集中在线粒体的内膜和外膜.
刘震, 张国强, 卢全伟
doaj  

IBA57基因突变引起的多发性线粒体功能障碍综合征1例并文献复习

open access: yesZhongguo shiyan zhenduanxue, 2021
多发性线粒体功能障碍综合征(Multiple mitochondrial dysfunction syndrome,MMDS)是一组由核基因突变引起的线粒体病,为常染色体隐性遗传病。本病依据基因改变分为6型,1-5型是由于参与Fe-S簇(iron-sulfur cluster,ISC)生物合成的核基因发生突变,导致线粒体呼吸链(mitochondrial respiratory chain,MRC)复合体和硫辛酸合酶(lipoic acid synthase,LIAS)功能障碍;
张萌   +4 more
doaj  

Endogenous/Exogenous Dual‐Responsive Bimetallic Hollow Nanozyme for Photothermal/Nanocatalysis/Immune Synergistic Tumor Therapy

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley   +1 more source

凤尾菇线粒体DNA片段的克隆与同源性分析

open access: yes四川大学学报. 自然科学版, 1996
将Sau3AI部分酶切的凤尾菇线粒体DNA插入质粒载体pBS+的BamHI位点,然后以凤尾菇线粒体DNA为探针与重组质粒DNA进行斑点杂交,筛选到6个阳性克隆.选取其中2个阳性克隆的插入片段,分别与来自6个属的13个食用菌品种的线粒体DNA进行Southern杂交,其结果显示两探针能与所有测定的侧耳属品种的线粒体DNA杂交,并具有多态性;但与其它属线粒体DNA只有不同程度的杂交.两探针中H4的杂交范围较广,而H2仅能与部分食用菌的线粒体DNA杂交 ...
曾凡亚, 汤海妹, 张义正
doaj  

Genetic Diversity and Phylogeographic Structure of the Edible Caterpillars of Gynanisa maja and Implications for the Sustainability of the Species in Namibia

open access: yesIntegrative Conservation, Volume 4, Issue 3, Page 405-415, September 2025.
Assessing the genetic diversity of edible insects harvested from the wild is a pre‐requisite for designing conservation and management policies. The caterpillars of Gynanisa maja (Saturniidae) are harvested in large numbers in mopane woodlands in southern Africa, where they represent a seasonal source of income and nutrition to many rural communities ...
Zwannda Nethavhani   +3 more
wiley   +1 more source

Next‐Generation Sequencing of Fecal DNA: A Novel Insight Into the Mitogenome Phylogeography of the Snow Leopard (Panthera Uncia) 粪便dna的二代测序:对雪豹线粒体组谱系地理结构的新洞察

open access: yesIntegrative Conservation, Volume 4, Issue 3, Page 277-286, September 2025.
This study provides an innovation to address the challenge in accessibility to samples and genetic markers in Snow leopard conservation genetic studies. We performed next‐generation sequencing (NGS) on 19 fecal samples obtained from the eastern Qinghai‐Tibet Plateau, and successfully assembled 17 complete mitogenome sequences (~16,720 bp) and ...
Chen Cheng   +7 more
wiley   +1 more source

Phylogenomic insights into the relationship and the evolutionary history of planthoppers (Insecta: Hemiptera: Fulgoromorpha) 基于基因组的系统发育分析为蜡蝉亚目(Fulgoromorpha)的系统发育关系及进化提供新见解

open access: yesSystematic Entomology, Volume 50, Issue 3, Page 495-518, July 2025.
Using genomic data from 285 species across 19 planthopper families, we conducted the first phylogenomic study targeting global planthoppers and inferred their phylogeny with the highest resolution so far. We proposed taxonomic changes including the establishment of a new family Borysthenidae stat. rev. and a new superfamily Meenoploidea superfam.
Junchen Deng   +9 more
wiley   +1 more source

Rapid, easy, sensitive, low‐cost and on‐site detection of environmental DNA and RNA using CRISPR‐Cas13

open access: yesMethods in Ecology and Evolution, Volume 15, Issue 8, Page 1408-1421, August 2024.
Abstract Environmental DNA (eDNA) monitoring of species distribution has become a critical tool in ecology, conservation biology and fisheries for identifying the presence and distribution of diverse organisms, including important, threatened and invasive species.
Jiwei Yang   +4 more
wiley   +1 more source

塔里木兔线粒体基因组全序列分析与系统进化研究

open access: yes野生动物学报, 2021
塔里木兔是我国新疆地区特有物种,已被列为国家Ⅱ级重点保护动物。本研究基于所测定的塔里木兔线粒体全基因组序列(全长17011 bp),进行了全序列的结构分析,结果表明塔里木兔线粒体基因组包含13个蛋白质编码基因、22个tRNA基因、2个rRNA基因和1个控制区。除了nad6在L链上以外,其他的蛋白质编码基因都在H链上。基于线粒体基因序列,通过生物信息学预测发现除了trnM和trnS1以外,其余tRNA都有经典的三叶草二级结构。线粒体全基因组具有AT偏好性,其结构与目前兔属其他物种线粒体基因组结构类似 ...
黄娅琳 1   +1 more
doaj  

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