Results 21 to 30 of about 15,831 (166)
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Rare Metals, Volume 45, Issue 1, January 2026.ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley +1 more source
First report of indolent cutaneous T‐cell lymphoma in a fennec fox (Vulpes zerda)
Veterinary Dermatology, Volume 36, Issue 5, Page 707-711, October 2025.A 10‐year‐old fennec fox (Vulpes zerda) was presented for multifocal regions of chronic alopecia and crusting. Cutaneous lymphocytosis was diagnosed through histopathological examination and immunohistochemical investigation. Clonal rearrangement of the T‐cell receptor gamma locus supports that lymphocytosis in this case is an indolent lymphoma ...
Kristen L. Shekelle +5 more
wiley +1 more source
Mechanistic Analysis of Immunomodulation by Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells in Mice [PDF]
, 2015 背景：间充质干细胞是具有自我更新能力和分化能力的组织细胞前体细胞，能够分化为一系列的间质细胞，包括成骨细胞、成软骨细胞、脂肪细胞、肌细胞和内皮细胞等。细胞治疗是再生医学发展的一个重要分支。越来越多的研究发现，间充质干细胞能够修复组织损伤，达到一定治疗效果。因此，间充质干细胞被视为天然组织工程材料的重要种子细胞，具有广阔的应用前景。此外，间充质干细胞具有负性免疫调节能力。在体外共培养条件下，间充质干细胞能够抑制免疫细胞功能，包括抑制T细胞反应，抑制树突状细胞的成熟和抗原提成，抑制B细胞激活和增殖 ...
李成林
core
Expression and Significance of gp96 and Immune-related Gene CTLA-4, CD8 in Lung Cancer Tissues [PDF]
, 2010 Background and objective It has been proven that gp96 plays an important role in specific cytotoxic immune response which is involved in anti-tumor effect in the body.
Haiyan ZHENG +4 more
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Is parvovirus B19 infection upsurge in 2023–2024 associated with adverse pregnancy outcome?
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 3, Page 307-313, September 2025.ABSTRACT Objective A surge in parvovirus B19 infections has been reported in 2023–2024 across Europe and the USA, raising concerns about the associated perinatal risks. The aim of this study was to compare perinatal outcomes following maternal parvovirus B19 infection during the 2023–2024 period with those from a pre‐2023 cohort.
S. Prasad +22 more
wiley +1 more source
采用双重免疫组织化学及免疫电镜方法可将α-平滑肌肌动蛋白定位于乳腺癌间质新生血管周细胞
Zhongguo shiyan zhenduanxue, 2002 目的 观察周细胞形态特点 ,并寻找其标记物。方法 应用双重免疫组织化学及免疫电镜方法 ,观察α -平滑肌肌动蛋白 （α -SMA）在周细胞内的表达情况。结果 免疫组织化学染色发现α -SMA在周细胞内表达 ,而在内皮细胞内不表达 ;免疫电镜可见α-SMA仅定位于周细胞。结论 免疫组织化学方法和免疫电镜方法是一种有效的实验手段 ,采用此种方法提出α ...
王医术 +5 more
doaj
Preliminary Studies of Neuropilin-1 Expression on HCC and Inhibitive Effect of Anti-NRP-1 Monoclonal Antibody on HCC Growth [PDF]
, 2015 摘要 研究背景和目的 肝癌是世界上最常见的恶性肿瘤之一，男性与女性中肝癌诊断率分别为世界第五和第七，男性及女性肝癌相关死亡率在癌症相关死亡中分别居第二和第六。肝细胞癌占所有肝癌的70%-85%，其诊断和治疗取决于多方面因素——肿瘤的大小，范围，全身和肝功能情况。早期确诊的肝癌患者，才有可能接受肝脏切除或移植等治疗。然而仅有10%-30%的肝细胞癌患者适合根治性治疗，大多数肝细胞癌患者，确诊时已经处于中晚期，无法行根治性治疗，且预后较差。而传统的介入治疗、放化疗存在抗肿瘤效果较差、副作用大等缺点 ...
张亚飞
core
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的对脂质体流感疫苗体液免疫和细胞免疫效果进行评价。方法血凝抑制法（HI）和ELISA法检测特异性抗体;MTT法检测小鼠淋巴细胞增殖情况;流式细胞仪测小鼠T淋巴细胞表面标记;ELISA法检测小鼠肺内溶物中细胞因子含量。结果脂质体流感抗原可激发更强的体液免疫;脾细胞增殖效率,CD4水平和CD4/CD8比例,以及细胞因子（IL-4、IFN-γ）水平均有显著的增强作用。结论脂质体流感疫苗能够刺激机体产生较高的体液免疫,并且能够激发机体产生细胞免疫。
戚凤春 +5 more
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