Results 11 to 20 of about 14,469 (162)

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy 纳豆激酶对糖尿病视网膜病变微血管病变和神经炎症的保护作用

Journal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023
Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong‐Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu, Weiqi Chen, Dingguo Huang   +11 more
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Evaluating the role of time in range as a glycemic target during short‐term intensive insulin therapy in patients with newly diagnosed type 2 diabetes 在新诊断的2型糖尿病患者中评估短期胰岛素强化治疗期间血糖达标时间作为血糖目标的作用

Journal of Diabetes, Volume 15, Issue 2, Page 133-144, February 2023., 2023
Highlights Whether time in range (TIR) during short‐term intensive insulin therapy (SIIT) was associated with treatment response to the therapy in patients with newly diagnosed type 2 diabetes was uncertain. TIRPIR, which was calculated according to the percentage of glucose points within predefined glycemic targets, was superior to TIR3.9–7.8mmol/L ...
Liehua Liu, Weijian Ke, Lijuan Xu, Hai Li, Juan Liu, Xuesi Wan, Jianbin Liu, Wanping Deng, Xiaopei Cao, Haipeng Xiao, Yanbing Li   +10 more
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The effect of short‐term intensive insulin therapy on inflammatory cytokines in patients with newly diagnosed type 2 diabetes 短期胰岛素强化治疗对新诊断的2型糖尿病患者炎性细胞因子的影响

Journal of Diabetes, Volume 14, Issue 3, Page 192-204, March 2022., 2022
Highlights Many proinflammatory cytokines could be decreased after 1 week of intensive insulin therapy using continuous subcutaneous insulin infusion (CSII). This was the first report showing that the cytokines of interleukin‐6 receptor (IL‐6R), tissue inhibitor of metalloproteinase‐2 (TIMP‐2), platelet‐derived growth factor type BB (PDGF‐BB), and ...
Junyu He, Peiji Dai, Liyi Liu, Yanqing Yang, Xibo Liu, Yanbing Li, Zhihong Liao   +6 more
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A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P. Mahabir, Michael R. Stegemann   +4 more
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Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers

Ultrasound in Obstetrics &Gynecology, Volume 56, Issue 3, Page 378-387, September 2020., 2020
ABSTRACT Objective To investigate the antenatal management and outcome in a large international cohort of monochorionic twin pregnancies with spontaneous or post‐laser twin anemia–polycythemia sequence (TAPS). Methods This study analyzed data of monochorionic twin pregnancies diagnosed antenatally with spontaneous or post‐laser TAPS in 17 fetal therapy
L. S. A. Tollenaar, F. Slaghekke, L. Lewi, Y. Ville, M. Lanna, A. Weingertner, G. Ryan, S. Arévalo, A. Khalil, C. O. Brock, P. Klaritsch, K. Hecher, G. Gardener, E. Bevilacqua, K. V. Kostyukov, M. O. Bahtiyar, M. D. Kilby, E. Tiblad, D. Oepkes, E. Lopriore, Collaborators, J. M. Middeldorp, M. C. Haak, F. J. C. M. Klumper, J. Akkermans, H. Delagrange , V. Pandya, S. Faiola, R. Favre, S. R. Hobson, C. Rodo, B. Thilaganathan, R. Papanna, P. Greimel, M. Tavares de Sousa, A. Carlin, K. A. Gladkova, J. A. Copel   +37 more
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G protein‐coupled receptor kinase‐2: A potential biomarker for early diabetic cardiomyopathy G蛋白偶联受体激酶2:早期糖尿病心肌病的潜在生物标记物

Journal of Diabetes, Volume 12, Issue 3, Page 247-258, March 2020., 2020
Highlights The GRK2 level elevated not only in the myocardium of diabetic mice with early stage of diabetic cardiomyopathy but also in the peripheral blood mononuclear cells of type 2 diabetic patients with the early stage of diabetic cardiomyopathy. The study findings suggested that the GRK2 was a potential biomarker for early diabetic cardiomyopathy.
Shuiqing Lai, Xiaoying Fu, Shufen Yang, Shuting Zhang, Qiuxiong Lin, Mengzhen Zhang, Hongmei Chen   +6 more
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International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua, Wenchong Du, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu   +6 more
wiley   +1 more source

Performance of non‐invasive prenatal testing in vanishing‐twin and multiple pregnancies: results of TRIDENT‐2 study

Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 6, Page 738-746, December 2025.
ABSTRACT Objective To evaluate the performance of non‐invasive prenatal testing (NIPT) in vanishing‐twin and multiple pregnancies. Methods This study was conducted as part of the TRIDENT‐2 study, in which NIPT was offered as a first‐tier screening test to women with a multiple pregnancy or vanishing‐twin pregnancy between 1 June 2020 and 31 March 2023 ...
J. C. A. van Eekhout, C. J. Bax, L. van Prooyen Schuurman, E. C. Becking, A. J. E. M. van der Ven, D. Van Opstal, E. M. J. Boon, M. V. E. Macville, M. N. Bekker, R. J. H. Galjaard, on behalf of the Dutch NIPT Consortium, E.A. Sistermans, L. Henneman, A. Polstra, E. Voorhoeve, S.L. Zelderen‐Bhola, E.M.J. Boon, M.P.R. Lombardi, M.C. Bakker, E.J. Bradley, E.M.J. Boon, C. Louwerens‐Zintel, M. Smit, M.C. van Maarle, M.B. Tan‐Sindhunata, K. van der Meij, H. Meij, C.J. Bax, E. Pajkrt, I.H. Linskens, L. Martin, J.T. Gitsels‐van der Wal, R. J. H. Galjaard, D. van Opstal, M.I. Srebniak, F.M. Sarquis Jehee, I.H.I.M. Hollink, F. Sleutels, W. de Valk, W.H. Deelen, A.M.S. Joosten, K.E.M. Diderich, M.E. Redeker, A.T.J.I. Go, M.F.C.M. Knapen, S. Galjaard, A.K.E. Prinsen, A.P.G. Braat, M.J.V. Hoffer, N.S. den Hollander, E.J.T. Verweij, M.C. Haak, M.V.E. Macville, S.J.C. Stevens, A. van der Wijngaard, L.H. Houben, M.A.A. van Esch‐Lennarts, L. Hamers, A.G.P. Jetten, S.A.I. Ghesquiere, B. de Koning, M. Zamani Esteki, C.J. Heesterbeek, C.E.M. de Die‐Smulders, H. Brunner, M.J. Pieters, A.B.C. Coumans, D.F.C.M. Smeets, B.H.W. Faas, D. Westra, M.M. Weiss, I. Derks‐Prinsen, I. Feenstra, M. van Rij, E. Sikkel, R.F. Suijkerbuijk, B. Sikkema‐Raddatz, I.M. van Langen, K. Bouman, L.K. Duin, G.H. Schuring‐Blom, K.D. Lichtenbelt, M.N. Bekker, E. van Vliet‐Lachotzki, J. Pot, A. J. E. M. van der Ven, S van 't Padje   +86 more
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Is parvovirus B19 infection upsurge in 2023–2024 associated with adverse pregnancy outcome?

Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 3, Page 307-313, September 2025.
ABSTRACT Objective A surge in parvovirus B19 infections has been reported in 2023–2024 across Europe and the USA, raising concerns about the associated perinatal risks. The aim of this study was to compare perinatal outcomes following maternal parvovirus B19 infection during the 2023–2024 period with those from a pre‐2023 cohort.
S. Prasad, A. Khalil, Y. Yinon, N. Regev, R. Brawura‐Biskupski‐Samaha, M. Massoud, N. Mazanowska, F. G. Sileo, F. Prefumo, P. Kosinski, J. Morales Rosello, F. D'Antonio, Collaborators, C. Ozan Ulusoy, D. Mohammed, M. Arora, A. Hegde, E. Klapholz, C. Berkovitz, K. Kosińska‐Kaczyńska, I. Rzucidło‐Szymańska, N. Szymecka‐Samaha, S. Ceffa   +22 more
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Placental biomarker and fetoplacental Doppler abnormalities are strongly associated with placental pathology in pregnancies with small‐for‐gestational‐age fetus: prospective study

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 6, Page 749-760, June 2025.
ABSTRACT Objective Placental dysfunction can result in small‐for‐gestational age (SGA) or fetal growth restriction (FGR). The aim of this prospective cohort study was to assess the association of the cerebroplacental ratio (CPR) and other more conventional fetoplacental Doppler indices, circulating placental growth factor (PlGF) levels and soluble fms ...
J. Hong, K. Crawford, E. Cavanagh, V. Clifton, F. da Silva Costa, A. V. Perkins, S. Kumar   +6 more
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