Results 11 to 20 of about 1,596 (100)
Journal of Diabetes, 2022 Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous ...
Mao‐Qiang Man +3 more
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Journal of Diabetes, Volume 15, Issue 5, Page 382-396, May 2023., 2023 HighlightsAutophagy is closely related to retinal neurovascular units in diabetes retinopathy. Different cells participate in the occurrence and development of diseases through autophagy, and targeted autophagy may be a new direction of treatment in the future. Emphasized the close relationship between diabetic retinopathy (DR) and autophagy Summarized
Xiongyi Yang +6 more
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Journal of Diabetes, Volume 15, Issue 4, Page 325-331, April 2023., 2023 Highlights Leukocyte telomere length was independently associated with the risk of cardiovascular mortality. Leukocyte telomere length was not associated with the risk of all‐cause mortality in patients with diabetes. Telomere length may be a predictor of cardiovascular mortality in diabetes.
Ziwei Chen +6 more
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Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022 Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques +4 more
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Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT The limited osteogenic capacity of magnesium phosphate cement (MPC) has constrained its biomedical applications, underscoring the necessity to develop MPC with enhanced physical properties and bone‐forming capabilities. In this study, a multifunctional MPC system was developed by incorporating zoledronic acid‐loaded near‐infrared (NIR ...
Bin Wang +8 more
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野生动物学报为深入探究细胞水平衰老与再生机制的差异，采用过氧化氢（H2O2）诱导马鹿（Cervus elaphus）快速生长期鹿茸软骨组织（CA）原代细胞，旨在探索构建衰老细胞模型的实验方法。通过使用不同浓度H2O2处理原代细胞，培养72 h后，利用CCK-8法筛选出半数效应浓度，同时结合衰老相关β-半乳糖苷酶（SA-β-Gal）染色评估衰老情况，以确定建模相关参数。进一步通过RT-qPCR和Western Blotting检测细胞中控制衰老TP53-CDKN1A（P21）轴的关键标记基因转录和蛋白表达水平 ...
王博 +5 more
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Zhongguo cuzhong zazhi, 2018 近年来，沉默信息调节蛋白1（silent information regulator protein 1，SIRT1）作为依赖NAD+ 的组蛋白去乙酰化酶被广泛地研究。SIRT1存在于机体各组织细胞中，通过去乙酰化修饰，调节细胞 的多种生理过程，在能量守恒、细胞氧化、衰老及凋亡等方面发挥重要作用。目前认为，SIRT1在缺血 性脑损伤中起到神经保护作用，可能通过调控细胞能量代谢，抗炎性反应、抗细胞凋亡等方面发挥 作用。本文主要综述了SIRT1在缺血性脑损伤中的神经保护作用。 Abstract:
李传文，汪青松
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Zhongguo shiyan zhenduanxue, 2022 目的 探讨60岁以上老年流感患者临床特征，分析进展为危重症流感患者危险因素，为临床早期识别高风险人群和干预提供依据。方法 回顾性分析2018年1月-2019年12月283例60岁以上流感老人的临床资料，根据临床表现分为危重症组、非危重症组两组，分析其临床特征。结果 在纳入研究的流感老年患者中，危重症组132例，非危重症组151例。危重症组男性明显多于女性，住院时间明显延长，患冠心病、COPD、肺结核病患者明显多于非危重症组 ...
李圆菲 +5 more
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Zhongguo shiyan zhenduanxue, 2018 老年斑是人体内脏衰老的象征,是人体老化的重要标志,也是皮肤老化的显著特征。目前认为,进入老年以后,细胞代谢机能减退,体内脂肪容易发生氧化,产生一种叫做脂褐质的极微小棕色颗粒堆积在皮肤的基底层细胞中,衰老的组织细胞失去应有的分解和排异功能,导致超量的棕色颗粒堆积在局部细胞基底层内,以及老年体内具有抗过氧化作用的SOD的活力降低了,自由基也就相对增加了,自由基及其诱导的过氧化反应长期毒害机体,从而在人体表面形成老年斑[1 ...
林花, 杨清, 黄晶
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Zhongshan Daxue xuebao. Yixue kexue ban, 1998 目的: 为明确卵巢早衰者外周血 T 淋巴细胞亚群及补体的特点。方法: 运用免疫酶组化技术———碱性磷酸酶— 抗碱 性磷酸酶( APAAP)法 ,检测卵巢早衰( POF)患者( n =30)、自然绝经后妇女(n=20)及健康育龄妇女( n =30)的外周血 T 淋巴细胞亚群,同时检测其补体水平。结果:①健康育龄妇女、卵巢早衰者及自然绝经者在外周血成熟 T 淋巴细胞总体水平 是一致的。 ②POF 患者及自然绝经后妇女的 CD+ 8 、CD+ 16 T 淋巴细胞数明显升高(P
王文军 邝健全
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