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Zhongshan Daxue xuebao. Yixue kexue ban缺血性脑卒中（CIS）是指因脑部血液循环障碍，缺血、缺氧所致的局限性脑组织的缺血性坏死或软化，其发病率在脑血管病中占据首位。氧气和营养供应的减少会导致神经元的严重丧失，并导致中风患者脑功能的缺陷。开发缺血性脑卒中的治疗方法仍然是临床医学的重要挑战。抗氧化剂N-乙酰半胱氨酸（NAC）是谷胱甘肽前体物质，缺血性脑卒中动物模型及一些临床研究的证据表明，NAC可以有效地保护大脑免受缺血损伤。本文从抗氧化、抑制炎症、保护脑神经和线粒体功能、稳定动脉斑块及溶栓功能等多方面阐述NAC在CIS中的作用机制 ...
杨晨, 万文辉
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Effect of Acupuncture as an Adjuvant Therapy for Intravenous Thrombolytic Treatment on Peripheral Inflammatory Factors and Neurologic Function in Patients with Acute Ischemic Stroke [PDF]
, 2022 BackgroundAcupuncture has proved effective in reducing inflammatory cytokine levels. However, it is still unclear about its improvement on the neurologic function and activities of daily living as well as over all clinical efficacy in patients with acute
CHEN An, CAO Xiao, ZHANG Huilin, LIAN Jianfeng
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The Glymphatic System：a New Exploration of Pathological Mechanism in Stroke [PDF]
, 2022 The glymphatic system is a system that promotes the exchange and flow of cerebrospinal fluid (CSF) -interstitial fluid (ISF) to maintain the balance of CSF-ISF, and rid the neuropil of toxic proteinaceous metabolites with astroglial water channel ...
YI Ting, JIN Shuoguo, YIN Haiyan, GAO Ping, ZHU Tianmin
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血浆同型半胱胺酸和D-二聚体水平与急性期脑梗死各亚型的关系 [PDF]
, 2014 目的：探讨血浆同型半胱胺酸和D-二聚体在急性期各亚型脑梗死之间的差异，为临床脑梗死亚型的病因学诊断提供理论依据。方法：收集我院246例24 h内发病的脑梗死患者，根据TOAST分型方法进行病因学分型：大动脉粥样硬化性脑卒中(1arge—artery atherosclerosis，LAA；n=66)、小动脉闭塞性脑卒中(small-artery occlusion ,SAO；n=76)、心源性脑栓塞(cardio embolism，CE；n=40)、其他确定原因引发的缺血性脑卒中(stroke of ...
Da-lin YU +6 more
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The Effect of Longitudinal Trajectories of Triglyceride-glucose Index on the New-onset Cardiovascular and Cerebrovascular Diseases [PDF]
, 2022 BackgroundTriglyceride glucose index (TyG) at baseline is an important influencing factor of cardiovascular and cerebrovascular diseases (CVD) , but there is still a lack of prospective cohort studies on the influence of TyG longitudinal trajectory on ...
CAO Zhiwei, LIU Qian, LI Jing, ZHANG Jing, JI Meiling, LIU Liwei, SONG Mingzhu, SUN Junyan, WU Yuntao
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Zhongguo cuzhong zazhi, 2023 出血性卒中主要有脑出血和蛛网膜下腔出血两类。出血性卒中虽然发病率低于缺血性卒中，但往往发病更急，症状更重，且预后更差。更重要的是，目前针对出血性卒中，特别是脑出血的有效干预措施欠缺。因此，出血性卒中指南的更新也受到了很大关注。本文对英国国家卒中临床指南2023版中出血性卒中部分的推荐要点进行解读。 Abstract: Hemorrhagic stroke mainly includes intracerebral hemorrhage and subarachnoid haemorrhage ...
李光硕1，赵性泉1，2
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髓磷脂抑制因子Nogo-A及其受体在缺血性脑卒中中的作用及机制研究进展 [PDF]
, 2018 作为临床常见的中枢神经系统血管性疾病,缺血性脑卒中具有发病率高、死亡率高、致残率高的\"三高\"特点[1]。从临床资料来看,脑卒中具有非常复杂的病理生理过程,其中一个重要原因是由于脑缺血再灌注后发生大脑局部缺血缺氧,造成组织细胞损伤,比如神经元损伤、轴突生长抑制等,导致运动、感觉、学习和记忆等神经功能障碍[2]。现有研究成果证明,髓磷脂抑制因子Nogo-A及其受体广泛存在于哺国家自然科学基金(81501207,81471265,31570845);;陕西省专项科研计划项目(16JK1645 ...
侯立朝 +5 more
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Brain White Matter Fiber Bundle Alterations and Severity of Depression in Patients with Post-stroke Depression [PDF]
, 2022 BackgroundPost-stroke depression (PSD) , a common complication in stroke patients, may increase the disability and mortality, however, its pathogenesis is unknown yet.ObjectiveTo observe the white matter fiber bundle alterations by diffusion tensor ...
QI Jie, ZHANG Lei, DENG Lijun, DUAN Xiaodi, DONG Binbin, SUI Rubo
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Latest Research on the Neuroprotective Mechanism of Short-chain Fatty Acids in Stroke and Its Relation with Post-stroke Cognitive Impairment [PDF]
, 2022 Post-stroke cognitive impairment is one of the common complications of stroke, seriously affecting patients' ability to perform activities of daily living.
LIU Huanhuan, LI Ruiqing, SU Kaiqi, YUAN Jie, LI Qi, FENG Xiaodong
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左房应变功能在非瓣膜性房颤患者发生缺血性脑卒中风险评估中的价值
Zhongguo shiyan zhenduanxue, 2023 目的 应用超声二维斑点追踪技术评估左房应变功能，探讨其在非瓣膜性房颤(NVAF)患者发生缺血性脑卒中风险评估中的应用价值。方法 选取2020年10月至2021年7月因非瓣膜性房颤在大连市中心医院住院患者181例，按是否合并缺血性脑卒中分为脑卒中组(40例)和非脑卒中组(141例);比较两组临床、左房应变功能等参数，应用单、多因素Logistic回归分析影响非瓣膜性房颤患者发生缺血性脑卒中的因素。采用受试者工作特征曲线(ROC)评价左房整体纵向应变(LA GLS)联合CHA2DS2 ...
杨官辉 +6 more
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