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Zhongguo shiyan zhenduanxue目的了解吉林省结核分枝杆菌对吡嗪酰胺的耐药水平和基因的突变特征，为吡嗪酰胺耐药的临床诊断提供依据。方法利用 BACTEC MGIT 960 系统对吉林省6个耐药监测点在2019年至2023年收集的376例分离株进行一线药物（利福平、链霉素、异烟肼、乙胺丁醇、吡嗪酰胺）液体药敏试验；对部分菌株进行全基因组测序并分析耐药相关基因突变。结果共计376名患者分离株中，吡嗪酰胺（PZA）表型耐药45例（12.0%）。PZA耐药与利福平（RFP）、链霉素（SM）、异烟肼（INH）耐药呈显著相关（均P<0.01）
王慧 +8 more
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野生动物学报, 2020 为了解圈养野生动物携带大肠杆菌的耐药表型和耐药基因型情况，从107份动物粪便样本和20份动物常用食物样本中分别分离出107株和13株大肠杆菌，通过微量肉汤法检测对7大类15种抗菌药物的耐药率，并筛查22种常见耐药基因的流行情况。结果显示，动物粪便样本中的大肠杆菌对四环素和磺胺类药物的耐药率较高，均为411%，其次是β内酰胺类为318%。草食动物源大肠杆菌有225%对至少1种药物耐药，肉食动物源为929%。耐药基因检出率较高是tetB、sulII、blaTEM 3种 ...
刘青 1 +1 more
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野生动物学报, 2020 为调查东北地区狐源大肠杆菌中氯霉素类耐药菌株的耐药基因分布情况，根据其耐药表型和流行情况，指导临床上合理用药。本试验采用PCR技术对224株狐源大肠杆菌的氯霉素类耐药基因cmlA、cat和floR进行检测，并结合耐药表型进行分析。结果表明：7723%（173/224）的狐源大肠杆菌具有氯霉素类耐药基因，cmlA、cat和floR基因在分离株的检出率分别为3259%、4375%和3527%，不同来源的大多数菌株能检测出耐药基因，且有部分大肠杆菌可携带2种或3种耐药基因。
冯涛 1 富景宁 2 薛原 1
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野生动物学报, 2022 为了分析火烈鸟(Phoenicopterus ruber)腹泻沙门菌(Salmonella)的致病性及耐药性情况,2016—2020年采集动物园中患腹泻火烈鸟的粪便、肛拭子和死亡火烈鸟的肝脏等病料组织102份,采用细菌分离鉴定和PCR方法进行沙门菌鉴定,采用人工感染小白鼠致病性试验和K-B药敏纸片法分别检测分离菌株的致病性和耐药表型情况。结果显示:从102份病料组织中分离得到89株沙门菌,其中75株沙门菌对小白鼠具有致病性,这75株沙门菌分离菌株对链霉素、阿莫西林、氨苄西林等14种药物耐药率在45.3 ...
邓丽玲 汪明权 李雨芮
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Modified rush venom immunotherapy in dogs with Hymenoptera hypersensitivity
Veterinary Dermatology, Volume 34, Issue 6, Page 532-542, December 2023., 2023 Background – Hymenoptera envenomation occurs frequently in people and dogs and can trigger anaphylaxis. Venom immunotherapy (VIT) is the only preventative treatment for Hymenoptera hypersensitivity and is indicated for people with severe adverse reactions to insect stings. Rush VIT is an accelerated VIT induction schedule performed in people.
Alexandra Moore +4 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 观察细胞周期调控因子SKP265380;P27kip1在白血病耐药细胞株HL-60/A和非耐药细胞株HL-60细胞中的表达及细胞周期比例,探讨细胞增殖与耐药的关系65377; 【方法】 RT-PCR65380;Western blot 检测SKP265380;P27kip165380;MRP mRNA及蛋白表达,流式细胞仪检测细胞周期,采用药物毒性分析方法检测细胞对化疗药物的敏感性65377; 【结果】 白血病耐药细胞株HL-60/A对阿霉素65380;柔红霉素65380 ...
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, 2002 目前 ,抗菌药物在水产养殖动物疾病防治中占有重要地位 ,然而 ,在水产养殖中使用抗菌药物也可产生一系列的副作用 ,例如细菌耐药性的产生和药物在鱼体和环境中的残留。本文就水产药物使用的历史、现状、适应症、副作用 ,耐药性的现状、来源、产生机制 ,耐药菌判定的标准 ,以及该领域的研究现状等问题进行综述与分析 ...
李爱华
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Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou +8 more
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Veterinary Dermatology, Volume 37, Issue 2, Page 200-210, April 2026.Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling +9 more
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Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan +5 more
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