Results 41 to 50 of about 23,607 (220)
Application of Flow Cytometric Bead Array Combined with Rolling Circle Amplification on the Multiplexed Detection of Tumor Markers [PDF]
, 2012 肿瘤标志物的有效检测对于恶性肿瘤的早期诊断、治疗观察和复发预测起着至关重要的作用。在临床应用中，单组分检测存在特异性不强、阳性率低等不足。因此，迫切需要发展多种标志物的联合检测技术以提高肿瘤诊断的准确性。流式微珠阵列技术(flowcytometricbeadarray，FCBA)又称液相芯片技术，是将溶液中的待检测物质通过生物分子间的特异性亲和反应结合在微米级的经光学编码的微珠上，利用流式细胞术对同一份微量样品中的多种待测组分同时进行快速、定性、定量分析的新型检测技术。目前 ...
高敏
core
External validation of QUiPP App in three independent European cohorts of symptomatic women
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 2, Page 163-174, August 2025.ABSTRACT Objective To validate externally the QUantitative Innovation in Predicting Preterm birth (QUiPP) App v.2 for the prediction of spontaneous preterm birth (sPTB) in symptomatic women attending tertiary care in Europe. Methods The QUiPP App v.2 was validated in three independent datasets: a prospective European multicenter cohort across five ...
A. M. Fischer +8 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2001 目的 探讨联合检测甲胎蛋白（ＡＦＰ）、甘氨酰脯氨酸二肽氨基肽酶同工酶Ｆ（ＧＰＤＡ－Ｆ）和γ－谷氨酞转肽酶同工酶Ⅱ（ＧＧＴ－Ⅱ）对原发性肝癌的互补诊断价值。方法 对１０１例肝癌和１２４例其他肝病患者血清ＡＦＰ、ＧＰＤＡＦ和ＧＧＴ－Ⅱ进行了同步检测，对比分析联合检测这三项指标对肝癌的互补诊断价值。结果ＡＦＰ、ＧＰＤＡ－Ｆ和ＧＧＴ－Ⅱ诊断肝癌的敏感性分别为 ７２．３％、８５．１％和 ６６．３％；联合检测 ＧＰＤＡ－Ｆ和 ＧＧＴ－Ⅱ或 ＡＦＰ可使敏感性提高至 ９２．１％和 ９３．１ ...
倪润洲 +4 more
doaj
血清CA153、BXTM及CEA联合检测对乳腺癌的早期诊断价值比较
Zhongguo shiyan zhenduanxue, 2020 目的分析血清肿瘤标志物CA153、BXTM与CEA单独及联合检测对乳腺癌的早期诊断价值。方法选择2014年2月-2015年1月来我院诊治的疑似乳腺癌患者286例,均行病理活检,采用酶联免疫法检测血清肿瘤标志物CA153、BXTM与CEA,比较乳腺癌及乳腺良性病变患者各指标差异,分析三指标单独检测及联合检测对乳腺癌的诊断效能。结果 286例患者病理检测确诊为乳腺癌108例,乳腺良性病变178例。乳腺癌患者血清CA153、CEA及BXTM水平均明显高于乳腺良性病变患者 ...
陈琛 +6 more
doaj
潜在血源传播患者梅毒血清学TRUST/TPPA与IgM抗体联合检测 [PDF]
, 2010 目的为潜在血源传播患者筛选梅毒血清学传染病指标。方法采用回顾性研究,对2006年6月1日～2009年12月31日本院23720例潜在血源传播患者与门诊患者的TRUST/TPPA联合检测结果进行分析比较;分析不同年度潜在血源传播患者TRUST-/TPPA+的百分率变化;对其中118份TRUST-/TPPA+的潜在血源传播患者血清标本同时采用TPPA法和FTA-ABS法进行Tp-IgM抗体检测。结果潜在血源传播患者和门诊患者的梅毒抗体阳性率分别为8.62%和26.69%,二者差异有显著性 ...
付左根 +5 more
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Application of Circulating Tumor DNA in Precision Diagnosis and Treatment of Colorectal Cancer [PDF]
Colorectal cancer (CRC) is one of the most common malignant tumors recorded worldwide. This condition has high morbidity and mortality and seriously endangers people's health.
CAI Jidong +5 more
core +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 2, Page 200-209, August 2025.Abstract Objectives Neonates with critical congenital heart disease (CCHD) are at risk for adverse early brain development and long‐term neurodevelopmental sequelae. Insulin‐like growth factor‐1 (IGF‐1) and insulin‐like growth factor binding protein‐3 (IGFBP‐3) are essential contributors to brain growth and maturation.
M. Nijman +33 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的评价平均红细胞体积（MCV）、红细胞（RBC）脆性试验、血红蛋白（Hb）电泳在产前筛查地中海贫血中的价值。方法选取来我院产前检查的经基因诊断确诊的地中海贫血患者140例,正常对照100例,分别进行MCV测定,RBC脆性试验和血红蛋白电泳试验,分析各单项试验及三项试验联合检测地中海贫血的灵敏度、特异度等评价指标。结果MCV、RBC脆性试验、Hb电泳单项检测对地中海贫血诊断的灵敏度及特异度分别为93.6%、89.3%、82.1%及78.0%、92%、97 ...
王晓忠, 曾学辉, 占葆娥
doaj
Role of RNA helicase DHX32 in the metastasis of hepatocellular carcinoma [PDF]
, 2016 肝细胞癌是全球性的高致死率肿瘤之一，血管侵犯和转移是肝细胞癌患者术后易复发及5年生存率较低的重要原因，有效的抗转移策略无疑能给患者带来福音。因此，越来越多的研究致力于探讨肝细胞癌发生侵袭转移的分子机制，并希望通过找到某些关键分子来干预肿瘤的转移。 DHX32是人类RNA螺旋酶的家族成员之一，最早被发现是在急性淋巴细胞白血病中低表达并参与淋巴细胞的分化，但是它的生物学功能尚未明确。我们课题组前期通过差异基因显示技术发现DHX32在结直肠癌中表达上调，功能研究结果显示DHX32与结直肠癌细胞的增殖 ...
胡情
core
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 1, Page 24-32, July 2025.ABSTRACT Objectives To investigate the impact of aspirin administration on the incidence of preterm birth, according to the type of delivery and gestational age at preterm birth, and to examine the hypothesis that aspirin delays preterm delivery. Methods This was a secondary analysis of a multicenter stepped‐wedge cluster randomized trial of a first ...
H. H. Y. Leung +29 more
wiley +1 more source