LMP-027 Anti-Clostridium difficile activity, drug combination synergetic/additive effect, and tolerant mutant screening and characterization [PDF]
, 2017 抗菌药物是对抗细菌感染的有力武器，自第一种抗生素青霉素被发现并应用于临床以来，人类已经开发出多种抗菌药物，然而由于抗菌药物的不合理使用，细菌耐药问题日益严峻，多重耐药菌不断出现，对人类健康构成严重威胁。这需要研发新型抗菌药物用于治疗多耐药细菌引起的感染；然而传统抗菌药物开发耗时长、成本高、风险大，医药公司对此并不热衷，新型抗菌药物上市越来越少。老药新用是抗菌药物开发的新思路，这些药物已经用于临床或正在进行临床试验，安全性评价资料齐全，这大大减少药物开发的成本和风险。过去几十年间 ...
刘俊坚
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Application of Gut Microbiota Research Models and Omics Techniques to the Risk Assessment of Chemical Hazards in Foods [PDF]
Chemical hazards in foods have become a global public health challenge with the widespread use of chemicals in food processing. Currently, the effects of chemical exposure on human health are usually assessed by relying on complex and invasive assays for
ZHAI Qixiao, YIN Pingping, WANG Shumin
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Effects of four functional feed additives on growth performance, lipid metabolism, non-specific immunity and health of liver and intestine of Anguilla marmorata [PDF]
, 2017 本论文以初始体长(41.54±0.83)cm，体质量(167.67±13.33)g的花鳗鲡为研究对象，在基础饲料中分别添加200mg/kg姜黄素(1组)、1000mg/kg丁酸钠(2组)、1000mg/kg果寡糖(3组)和1000mg/kg复合中草药提取物(4组)配制成4种等氮等能的试验饲料，基础饲料为对照组(5组)饲料，开展为期60d的饲养试验，探讨4种功能性饲料添加剂对花鳗鲡生长性能、脂肪代谢、非特异性免疫、肝肠组织形态和肠道菌群结构的影响，为其在花鳗鲡配合饲料中的应用积累基础资料 ...
解文丽
core
野生动物学报, 2021 在圈养条件下，为了探知孟加拉白虎（Panthera tigris tigris）的肠道菌群结构以及不同年龄孟加拉白虎的肠道菌群差异，对亚成年和成年孟加拉白虎的粪便菌群进行高通量测序分析。结果表明：在2组白虎的肠道菌群中，放线菌门（Actinobacteria）和厚壁菌门（Firmicutes）最为优势，比例达80%以上；柯林斯菌属（Collinsella）比例最高，平均含量为438%，梭杆菌属（Fusobacterium）、布劳特氏菌属（Blautia）和瘤胃球菌类群（Ruminococcus ...
苏凯#雷英#金修哲李金邦
doaj
Molecular diversity of the intestinal bacterial flora in small abalone, Haliotis diversicolor [PDF]
, 2010 杂色鲍是我国南方沿海海水养殖的重要经济贝类。肠道菌群在宿主生长发 育、新陈代谢等方面起到重要作用。通过开展杂色鲍肠道菌群多样性的研究，旨 在理解肠道菌群与杂色鲍之间相互关系，包括消化食物、病理发生等，对探讨微 生物与海洋无脊椎动物相互关系具有重要意义。 本文通过微生物分离培养鉴定与不依赖培养的微生物分子生态学方法对不 同养殖环境的杂色鲍肠道菌群的多样性进行研究。从两个养鲍场（江口、大嶝） 杂色鲍肠道内共分离到35株细菌，经16SrRNAgene分子鉴定分属于9个属， 分别为Vibrio ...
黄兆斌
core
Effect to Intestinal Microbiota Regulation and Laxative Function to Lactobacillus paracasei [PDF]
The effects of five strains of Lactobacillus paracasei from Tibet on constipation and gut microbiota of mice were studied. One hundred and sixty male Kunming mice were randomly divided into two groups: A and B.
Jing YANG +8 more
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Zhongguo shiyan zhenduanxue, 2017 1肠道菌群与2型糖尿病人体胃肠道中存在着大量的正常菌群,其肠道内微生物主要由厚壁菌门、拟杆菌门、放线菌门、变形菌门以及疣微球菌门组成,而厚壁菌门及拟杆菌门占优势,某些病毒及真核生物也同时存在于肠道内[3]。肠道菌群和肥胖症的发生有很大的关系,其与2型糖尿病的关系亦是如此,有学者发现,改变肠道菌群构成 ...
宋丹丹, 刘煜
doaj
Changes in intestinal flora of coal workers' pneumoconiosis patients after tetrandrine intervention [PDF]
BackgroundPneumoconiosis is a widespread occupational disease in China at present. As a type of lung diseases, its pathological damage is mainly irreversible fibrotic changes in the lungs. Several studies have shown that the occurrence and development of
Baoping LI +9 more
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Analysis of Gut Flora in a Mouse Model of Esophageal Squamous Cell Carcinoma in Situ [PDF]
, 2022 BackgroundWith the application and development of high-throughput sequencing-based approaches for gut flora analysis, increasing studies have confirmed that gut flora is closely related to the development of various cancers.
ZHANG Yushuang, YU Fuyang, WU Zhongbing, WANG Yiran, LI Jing
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野生动物学报, 2022 为了优化人工饲养大壁虎（Gekko gecko）的膳食结构及养殖程序，研究了蝗虫（Locusta migratoria manilensis）、黄粉虫（Tenebrio molitor）、土鳖虫（Eupolyphaga sinensis）及大麦虫（Zophobas morio）4种昆虫饲料对大壁虎生长速度的影响，并通过16S rDNA高通量测序技术比对了大壁虎胃肠道微生物菌群差异及冬眠期与捕食期的大壁虎胃肠道微生物菌群差异。结果表明：饲喂不同昆虫饲料对大壁虎的增重效果不同。单一昆虫饲料组中 ...
赵成坚 1 全琛宇 2 霍娟 1 徐永莉 1 姜建萍 1
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