Results 41 to 50 of about 24,880 (158)
Applying TALEN and CRISPR/Cas9 Technique to Knock out the PD1 Gene in Human Primary T Lymphocytes [PDF]
, 2016 过继性细胞免疫治疗(adoptivecellularimmunotherapy)是将患者自体免疫细胞在体外处理，然后筛选并大量扩增具有高度特异性的肿瘤杀伤性免疫效应细胞，再回输到患者体内杀灭肿瘤的一种治疗方法，过继性T细胞治疗是一种很有前景的癌症治疗方法。体内T细胞在进行免疫应答时，T细胞活化需要双重信号的协同作用，分别是抗原呈递信号和协同刺激信号。协同刺激分子通过为淋巴细胞提供正性或负性的调控信号参与机体的免疫调控。肿瘤细胞会利用体内免疫调节过程，表达或分泌的一些分子，对T细胞进行负向调控 ...
李剑
core
New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics
Rare Metals, EarlyView.ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu +8 more
wiley +1 more source
中西医结合护理This article summarized the multidisciplinary collaboration and nursing practice of bone marrow suppression combined with catheter-related bloodstream infection (CRBSI) of implanted port in a patient undergoing chemotherapy for lung cancer.
WEI Ya (魏雅) +5 more
doaj +1 more source
Rare Metals, EarlyView.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
中西医结合护理Objective To understand the establishment and application experience of whole-course management nursing path for lymphoma patients by navigation nurses, and to provide reference for the construction of whole-course management for lymphoma patients ...
WANG Shijuan (王石娟) +6 more
doaj +1 more source
c-Src promotes tumor cell proliferation by activating HK2 [PDF]
, 2015 大多数肿瘤细胞即使在氧气充足的情况下依然主要靠糖酵解方式提供能量，这就是著名的Warburg效应，它是肿瘤代谢的一个重要特征。己糖激酶（hexokinase，HK）是糖酵解过程中的第一个限速酶。在哺乳动物体内，HK主要有四种亚型，即HK1、HK2、HK3和HK4，其中HK2与肿瘤的关系最为密切。目前研究表明Warburg效应的发生与原癌基因（如Ras，c-Myc，HIF-1）的过度激活和抑癌基因(如p53)的失活密切相关。c-Src是哺乳动物中最早发现的原癌基因 ...
王随利
core
International Journal of Cancer, Volume 158, Issue 5, Page 1156-1165, 1 March 2026.Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li +5 more
wiley +1 more source
中西医结合护理This paper reviewed current research status of pain catastrophizing in patients with lung cancer after surgery, and summarized the concept, theoretical basis, assessment tools, epidemiological characteristics, influencing factors and management ...
BIAN Guanjun (边冠军) +2 more
doaj +1 more source
The effects of axon guidance factor Slit3 on metastasis of human fibrosarcoma [PDF]
, 2015 我们通过在纤维肉瘤细胞HT1080过表达Slit3基因，分析Slit3对肿瘤细胞侵袭转移作用.Transwell侵袭实验中，Slit3过表达后抑制HT1080的迁移侵袭，在裸鼠皮下成瘤实验中，肿瘤体积明显变小、重量明显降低，Slit3过表达后抑制HT1080肿瘤细胞的侵袭转移。此外肿瘤切片HE染色后发现GFP组有病灶点，而slit3过表达则少见，这个结果说明，Slit3显著抑制HT1080细胞转移。slit3过表达后MMP2,MMP9的表达明显降低，而MMP3，MMP13表达量上调 ...
刘咏梅
core
六维床在头、胸、腹部肿瘤常规直线加速器放射治疗中的摆位误差回顾性分析
Fushe yanjiu yu fushe gongyi xuebao回顾性分析基于加速器六维床摆位的肿瘤患者的CBCT（Cone-Beam CT，CBCT）图像，比较患者的摆位误差数据，分析肿瘤患者六维床放射治疗中分次内摆位误差的数据，研究六维床对不同位置肿瘤产生的摆位效果差异。选取2020年3月至2023年9月于本中心接受放疗的肿瘤患者85例，分成脑瘤、肺癌、直肠癌和乳腺癌。统计4组患者在左右、头脚、腹背6个自由度（X、Y、Z和Rx、Ry、Rz）的首次和分次内摆位误差。采用双样本异方差t检验对比分析不同瘤种在各个方向上的分次内摆位误差 ...
万 宝 +8 more
doaj +1 more source