Results 51 to 60 of about 38,945 (161)

Safety and Efficacy of Aumolertinib as First‐Line Treatment in EGFR‐Mutant Lung Adenosquamous Carcinoma: A Multicenter, Single‐Arm, Prospective Phase II Study (ARISE Study)

MedComm, Volume 7, Issue 8, August 2026.
Aumolertinib treatment resulted in improved clinical activity in EGFR‐mutant ASC. ABSTRACT Lung adenosquamous carcinoma (ASC) is a rare histological subtype of non‐small cell lung cancer (NSCLC), and prospective data regarding the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in this patient population remain ...
Longfeng Zhang, Long Huang, Dingzhi Huang, Zhe Liu, Yongfeng Yu, Kang Miao, Qian Miao, Xiaobin Zheng, Yiquan Xu, Qian Chu, Gen Lin   +10 more
wiley   +1 more source

Progress of Traditional Chinese Medicine in the treatment of chemotherapy-induced hiccup (肿瘤化疗相关性呃逆的中医治疗进展)

中西医结合护理
In people with cancer, certain chemotherapy drugs can have hiccups as a side effect, seriously affecting the quality of life. According to the Traditional Chinese Medicine theory, the chemotherapy-induced hiccup is associated with Zangfu, blood stasis ...
GAO Juan (高娟), CHENG Zhi (程誌), TANG Qingqing (唐晴晴), ZHANG Fengjuan (张凤娟)   +3 more
doaj   +1 more source

Targeting and Energy‐Depleting Biomimetic Nanoparticles for Enhancing Combined Chemo‐Sonodynamic Therapy Against Esophageal Cancer

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT Esophageal cancer is the seventh leading cause of cancer death, and the energy depletion in cancer cells can be achieved through synergistic therapy. The integration of sonodynamic therapy and chemotherapy offers a promising comprehensive treatment strategy for esophageal cancer.
Mengya Li, Ruimei Jin, Shengxi Zhou, Jingan Li, Kun Zhang   +4 more
wiley   +1 more source

Efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis after PICC catheters placement in patients with malignant lymphoma (紫草油纱湿敷防治恶性淋巴瘤患者PICC置管机械性静脉炎的效果观察)

中西医结合护理
Objective To investigate the efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis caused by peripherally inserted central catheter(PICC) catheters placement in patients with malignant lymphoma.
WANG Shijuan (王石娟), LI Min (李敏), LU Changyuan (卢昌媛), HUANG Silin (黄思霖), ZHANG Lifeng (张丽凤), LAO Yongcong (劳永聪)   +5 more
doaj   +1 more source

Prospective external validation of ADNEX and RMI for estimating risk of malignancy in adnexal masses in general gynecological settings: Danish multicenter study

Ultrasound in Obstetrics &Gynecology, Volume 68, Issue 2, Page 256-269, August 2026.
ABSTRACT Objectives The primary aims of this study were to validate externally the diagnostic performance of the Assessment of Different NEoplasias in the adneXa (ADNEX) model for distinguishing between malignant and benign adnexal masses, when used by non‐expert ultrasound examiners in general gynecological settings with a low prevalence of ovarian ...
I. M. Dueholm Hjorth, B. H. Bech, A. Ledger, C. Møller, T. Van den Bosch, O. Mogensen, Collaborators, R. Al Taie, C. Blach Kristensen, M. Lundegaard Iversen, P. Bor, M. Stentebjerg   +11 more
wiley   +1 more source

菊芋提取物在制备抗肿瘤药物或抗肿瘤保健品中的应用

, 2010
本发明涉及抗肿瘤药物，具体地说为菊芋的有机溶剂提取物在制备抗肿瘤药物或抗肿瘤保健品中的应用。体外细胞实验表明，菊芋叶乙酸乙酯提取物对多种肿瘤细胞，如肺癌细胞株(A549)，乳腺癌细胞株(MCF-7)，宫颈癌细胞株(Hela)，肾癌细胞株(ACHN)均有抑制作用 ...
肖红斌, 程孟春, 杜昱光, 程受衍, 袁晓艳   +4 more
core  

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

天然产物莱菔素通过下调crm1表达抑制套细胞淋巴瘤细胞增殖

, 2018
目的:研究染色体区域维持因子1(chromosomal region maintenance1,CRM1)在套细胞淋巴瘤中的表达情况,并进一步探讨天然产物莱菔素LFS-01抑制套细胞淋巴瘤细胞增殖的分子机制。方法:通过Oncomine数据库挖掘分析CRM1在套细胞淋巴瘤中的表达水平。用LFS-01处理套细胞淋巴瘤JeKo-1细胞后,采用CCK-8法检测细胞增殖活性,激光共聚焦显微镜下观察CRM1蛋白的核转运功能,蛋白质印迹法检测CRM1蛋白表达水平,FCM法检测和透射电子显微镜观察细胞周期和凋亡 ...
楚慧郢, 李国辉, 蔡娟, 王海娜, 杨永亮   +4 more
core   +1 more source

MMP-9在口腔癌转移中的研究进展

Zhongguo shiyan zhenduanxue, 2022
＜正＞从世界范围看，头颈部恶性肿瘤的发病率较高，口腔恶性肿瘤属于头颈部肿瘤，位居全身恶性肿瘤的第六位。在我国，口腔颌面部的恶性肿瘤以鳞状细胞癌最为多见，占80%以上。口腔癌（OSCC）转移是导致患者死亡的主要原因，在肿瘤转移的过程中，肿瘤细胞诱导血管的形成、肿瘤细胞黏附能力的变化、破坏细胞外基质（ECM），肿瘤细胞的运动能力和逃避免疫监视对肿瘤的转移也起了重要作用。
高瑞琪, 姜智雯, 秦高伟, 刘新
doaj  

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, Volume 13, Issue 38, 9 July 2026.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source