Results 71 to 80 of about 37,446 (161)
, 2018 目的:研究染色体区域维持因子1(chromosomal region maintenance1,CRM1)在套细胞淋巴瘤中的表达情况,并进一步探讨天然产物莱菔素LFS-01抑制套细胞淋巴瘤细胞增殖的分子机制。方法:通过Oncomine数据库挖掘分析CRM1在套细胞淋巴瘤中的表达水平。用LFS-01处理套细胞淋巴瘤JeKo-1细胞后,采用CCK-8法检测细胞增殖活性,激光共聚焦显微镜下观察CRM1蛋白的核转运功能,蛋白质印迹法检测CRM1蛋白表达水平,FCM法检测和透射电子显微镜观察细胞周期和凋亡 ...
楚慧郢 +4 more
core +1 more source
Precision Medical Sciences, Volume 15, Issue 2, Page 128-134, June 2026.This study showed the puncture angle guide device assisted 125I seeds implantation is safe and feasible. Compared with the manual deployment of needles, the puncture time, the number of puncture needle adjustments, and the number of intraoperative CT scans are significantly reduced, which can be used in clinical applications.
Yufeng Zhang +7 more
wiley +1 more source
Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Lung cancer is one of the most common and deadly malignancies worldwide. Although immune checkpoint inhibitors, including PD‐1/PD‐L1 blockers, have benefited a subset of patients, response rates remain limited, and recurrence is frequent because of the immunosuppressive tumor microenvironment (TME), characterized by hypoxia and dysregulated ...
Yi Ma +6 more
wiley +1 more source
Research progress of Ruyi Jinhuang Powder in the treatment of pressure injuries (如意金黄散治疗压力性损伤的研究进展)
中西医结合护理Pressure injury (PI) is a common skin problem that occurs most often in patients who are bedridden or have limited mobility, seriously affecting the quality of life of patients.
ZHU Yuxin (朱雨昕) +2 more
doaj +1 more source
, 2004 本发明涉及结构式I和结构式II人参皂苷苷元衍生物3β，12β-二羟-20(21)，24(25)-二烯-达玛烷[dammar-3β，12β-dihydroxyl-20(21)，24(25)-diene，简称Δ20(21)-PPD]和3β，6α，12β-三羟-20(21)，24(25)-二烯-达玛烷[dammar-3β，6α，12β-trihydroxyl-20(21)，24(25)-diene，简称Δ20(21)-PPT]，特别是涉及以Δ20(21)-PPD或和Δ20(21)-PPT以及含有Δ20(21)-
杨凌, 王秀丽, 李鹏, 何克江
core
, 2001 肿瘤转移在肿瘤发展进程中具有十分重要的作用。恶性肿瘤患者很少死于原发癌，绝大多数死于肿瘤转移。目前对于肿瘤转移的机理了解甚少，也缺乏有效的控制和治疗手段。１９９５年Dong犤１犦首次发现的肿瘤转移抑制基因KAI１以及近年来对其机理的研究取得了新进展，研究表明该基因只对肿瘤转移产生抑制作用，而对肿瘤形成没有影响。本文拟就KAI１基因与肿瘤转移抑制的相关性作一综述。１KAI１基因的发现与定位前列腺癌在美国的死亡率较高，其发病率更是高得惊人。在７０－８０岁死于其它原因的男性中，有５０％患有局限性的前列腺肿瘤 ...
张鸣青, 吴乔, 陈玉强
core
中西医结合护理With the transformation of medical model, patients have higher requirements for clinical nursing services. Humanistic care is the core content of modern nursing, which can enhance the nurse-patient relationship and improve the patient treatment ...
TANG Qian (唐倩) +4 more
doaj +1 more source
, 2005 本发明涉及具有抗肿瘤活性的低极性人参皂苷组合物，根据制备方法及其活性特点，将低极性人参皂甙分为七组，本发明特别是涉及二醇I组与其余六组低极性人参皂甙中任何一组或多组低极性人参皂甙的混合物。所述的组合物充分发挥各种低极性人参皂甙的特点，使抗癌活性显著增强，组合物具有诱导肿瘤细胞分化、诱导肿瘤细胞凋亡、抑制肿瘤生长、逆转肿瘤多药耐药性、抑制肿瘤新生血管生成、抑制肿瘤的浸润和转移、增强机体免疫力和降低化疗药物毒副作用等抗肿瘤活性，极具开发潜力 ...
杨凌, 何克江
core
, 2016 本发明涉及主动靶向型抗脑肿瘤药物及其制备方法。具体地，本发明公开了一种复合物，所述复合物包括：纳米载体，所述纳米载体的粒径小于200nm；和靶分子，所述靶分子偶联于所述纳米载体的表面，并与血脑屏障上的神经肽受体Y1和脑肿瘤细胞上的神经肽受体Y2均具有高的亲和性。本发明还公开了包含所述复合物的组合物及其制法和用途。所述复合物或所述组合物可有效跨越血脑屏障进入脑部，且可与脑肿瘤细胞高特异性结合，从而将抗肿瘤药物靶向输送至肿瘤细胞内，有效提高细胞内的药物浓度 ...
吴爱国, 田宇辰, 李娟
core