Results 61 to 70 of about 18,307 (120)

Optimal Adjuvant Therapy Selection for Chinese BRAF V600‐Mutant Stage III Melanoma: A Multicenter Efficacy Comparison of Targeted Agents, Immunotherapy, and Combinatorial Strategies

open access: yesMedComm, Volume 7, Issue 5, May 2026.
Adjuvant dabrafenib plus trametinib (D/T) therapy appears to offer the greatest clinical benefit for Chinese patients with stage III BRAF V600‐mutant melanoma. Furthermore, to maximize therapeutic efficacy in this population, extending D/T therapy beyond 1 year may be advisable. For Chinese patients who are unable to tolerate the febrile adverse events
Rongcheng Zhang   +17 more
wiley   +1 more source

Efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis after PICC catheters placement in patients with malignant lymphoma (紫草油纱湿敷防治恶性淋巴瘤患者PICC置管机械性静脉炎的效果观察)

open access: yes中西医结合护理
Objective To investigate the efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis caused by peripherally inserted central catheter(PICC) catheters placement in patients with malignant lymphoma.
WANG Shijuan (王石娟)   +5 more
doaj   +1 more source

Metal‐Doped Carbon‐Based Nanomaterials: Photothermal Mechanism Innovation and Precision Therapy Advancement in Antibacterial and Antitumor Applications

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Metal‐doped carbon‐based nanomaterials (M‐CNM) play a strategically significant role in next‐generation precision antibacterial and antitumor therapies, as they integrate synergistic photothermal ablation, catalytic reactive oxygen species (ROS) generation, and multimodal imaging capabilities. However, their clinical translation is hindered by
Pengxiang Liu   +5 more
wiley   +1 more source

MMP-9在口腔癌转移中的研究进展

open access: yesZhongguo shiyan zhenduanxue, 2022
<正>从世界范围看,头颈部恶性肿瘤的发病率较高,口腔恶性肿瘤属于头颈部肿瘤,位居全身恶性肿瘤的第六位。在我国,口腔颌面部的恶性肿瘤以鳞状细胞癌最为多见,占80%以上。口腔癌(OSCC)转移是导致患者死亡的主要原因,在肿瘤转移的过程中,肿瘤细胞诱导血管的形成、肿瘤细胞黏附能力的变化、破坏细胞外基质(ECM),肿瘤细胞的运动能力和逃避免疫监视对肿瘤的转移也起了重要作用。
高瑞琪, 姜智雯, 秦高伟, 刘新
doaj  

A Dual‐Function Mitochondria‐Targeted Polyoxometalate Nanomicelle Boosts Pyroptosis‐Dependent Antitumor Immune Response in Triple‐Negative Breast Cancer

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is often limited, whereas the immunotherapeutic potential of pyroptosis is frequently undermined by a compensatory surge in mitophagy. To address this challenge, this study developed a reactive oxygen species (ROS)‐responsive and mitochondria‐targeted nanomicelle (POM@CTT ...
Qingqing Dou   +6 more
wiley   +1 more source

Biomimetic Metallopeptidases for Biomedical Applications: From Modular Design to Disease Treatment

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Biomimetic metallopeptidases, as an emerging class of artificial enzyme systems, have demonstrated tremendous application potential in the biomedical field in recent years. Their core design principle is to rationally control amino acid composition and three‐dimensional conformation so that programmable peptide sequences can efficiently ...
Ke Ma, Ke‐Zheng Chen, Sheng‐Lin Qiao
wiley   +1 more source

Aspect Ratio‐Controlled Chiral Nanostructures for Dual‐Mode Breast Cancer Theranostics

open access: yesRare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Chiral CdSe/CdS quantum dots (QDs) have emerged as promising platforms for precise cancer diagnosis and therapy due to their unique optical properties and biological interactions. In this study, we systematically investigated the role of aspect ratio (AR) modulation in ultrathin‐shelled chiral CdSe/CdS dot‐in‐rods (DRs) on their performance in
Linxuan Wu   +9 more
wiley   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

open access: yesAdvanced Science, Volume 13, Issue 19, 2 April 2026.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng   +12 more
wiley   +1 more source

Research progress of Ruyi Jinhuang Powder in the treatment of pressure injuries (如意金黄散治疗压力性损伤的研究进展)

open access: yes中西医结合护理
Pressure injury (PI) is a common skin problem that occurs most often in patients who are bedridden or have limited mobility, seriously affecting the quality of life of patients.
ZHU Yuxin (朱雨昕)   +2 more
doaj   +1 more source

磁共振弥散成像对脑肿瘤周水肿区的诊断价值

open access: yesZhongguo shiyan zhenduanxue, 2007
目的通过对85例脑肿瘤以及5例炎性病变瘤周水肿区行磁共振弥散加权成像检查,探讨瘤周水肿的DWI表现在脑肿瘤诊断方面的临床应用价值。方法对脑肿瘤进行常规MRI序列扫描和DWI检查,均经手术和病理证实。对照分析病变的实质部分、周围水肿区以及正常脑组织的ADC值。全部数据经过SPSS(12.0)统计分析软件处理,各区域的瘤间差异用方差分析。统计结果均以-x±s表示 ...
陈红
doaj  

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