Results 51 to 60 of about 24,880 (158)
Design, Synthesis and Evaluation of Novel Benzamide Derivatives as Antitumor Agents [PDF]
, 2016 肿瘤作为威胁人类身体健康的一种重大疾病，其治疗一直被全世界所重视。随着研究的不断深入，研究发现肿瘤是复杂的疾病，其生长和存活不仅仅依赖于一种受体或一种信号通路。单一靶点药物不能阻断肿瘤的所有信号通路，而联合用药又有可能影响药物的吸收和代谢，甚至造成更加严重的药物不良反应。因此，多靶点抗肿瘤药物随之诞生，它能够同时作用于某一肿瘤的多个靶点从而产生多种药理活性。相较于单一靶点而言，具有避免药物相互影响、作用全面、不良反应少等优势。 本文以课题组前期研究中发现的化合物HJ-47和YSM-14为先导化合物 ...
黄志宁
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中西医结合护理To summarize the experience of hospice care with Traditional Chinese Medicine characteristics in the end-stage of a patient with small cell lung cancer with multiple systemic metastases.
LU Meiling (卢美玲)
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Silencing of PKM2 promotes Fas-Dependent Apoptosis via P53 -Mediated in Gastric cancer Cells [PDF]
, 2015 背景和目的：PKM2作为丙酮酸激酶（pyruvatekinaseisoenzyme，PK）家族成员，在肿瘤中呈现高表达，并且在肿瘤能量代谢过程中起到关键作用。近期研究发现，PKM2还具备转录因子活性，参与调控细胞增殖与迁移侵袭，在恶性肿瘤的发生发展中发挥重要作用。我们研究发现，胃癌细胞株BGC823及AGS中基因沉默PKM2后，促进了顺铂诱导的细胞凋亡，由此表明PKM2可以减低胃癌细胞对化疗药物的敏感性，但具体机制有待探索 ...
宋俊娇
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Polydopamine-Functionalized Graphene Oxide: A Versatile Nanocarrier for Chemotherapy and Photothermal Therapy [PDF]
, 2015 光热治疗是一种新型的肿瘤治疗技术，与传统的治疗手段相比，其具有独特的优点，如侵入性低、恢复时间短及并发症发生率小，而将光热治疗与传统的化学药物治疗结合在一个体系里，使热和化疗药物同时作用于肿瘤部位，能够更有效的杀死癌细胞。 石墨烯作为一种二维碳纳米材料，具有超高的比面积和强的近红外光吸收能力，在药物输送与光热治疗方面有着潜在的应用价值。然而，目前的研究中，石墨烯主要是通过π-π堆叠和疏水性相互作用装载疏水性药物，无法实现对那些与之无相互作用的亲水性药物的装载 ...
张馨元
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中西医结合护理In people with cancer, certain chemotherapy drugs can have hiccups as a side effect, seriously affecting the quality of life. According to the Traditional Chinese Medicine theory, the chemotherapy-induced hiccup is associated with Zangfu, blood stasis ...
GAO Juan (高娟) +3 more
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响 Impact on the apoptosis, invasion, proliferation ET-1 interfere with the formation of lung cancer [PDF]
, 2015 摘要 目的: 肺癌是最常见的恶性肿瘤之一,威胁着全世界人民生命和健康。同时它也是世界上发病率和死亡率增长最快的疾病之一。而且大多数肺癌患者到晚期才被诊断发现，在现阶段肺癌的治疗中，它仍然是无法治愈的。Endothelin(ET),由内皮细胞合成，是一种生物活性肽,是一种强烈的血管收缩剂，具有很强的收缩血管作用,随着对内皮素研究的不断深入，人们发现内皮素与肿瘤关系密切，对肿瘤细胞的生长、增殖、转移、凋亡及化学耐药等都方面都有影响。ET能够产生细胞生长因子可以促进肿瘤DNA合成,基因表达和肿瘤细胞增殖 ...
张振宇
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中西医结合护理Objective To investigate the efficacy of Lithospermum oil gauze wet compress in preventing and treatment of mechanical phlebitis caused by peripherally inserted central catheter(PICC) catheters placement in patients with malignant lymphoma.
WANG Shijuan (王石娟) +5 more
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Photodynamic and antiangiogenic effect of fullerene-cyclodextrin/thalidomide inclusion compound [PDF]
, 2016 近年来肿瘤发病率有呈上升的趋势，由于传统治疗方法有风险大、毒副作用强等弊端，人们积极寻找更安全有效的治疗手段。光动力治疗（photodynamictherapy，PDT）具有非侵入性、可多次安全重复使用等优点。抗肿瘤血管生成治疗（antiangiogenictherapy）以肿瘤血管内皮细胞为作用靶点，系统毒性较小，不易产生耐药性，与肿瘤化学药物联用可以起到协同效应。纳米颗粒输送系统基于生物体实体瘤的高通透性和滞留效应（enhancedpermeabilityandretentioneffect，EPR）
周童
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Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer [PDF]
, 2011 Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer ...
Boshi WANG +7 more
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Research progress of Ruyi Jinhuang Powder in the treatment of pressure injuries (如意金黄散治疗压力性损伤的研究进展)
中西医结合护理Pressure injury (PI) is a common skin problem that occurs most often in patients who are bedridden or have limited mobility, seriously affecting the quality of life of patients.
ZHU Yuxin (朱雨昕) +2 more
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