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Diabetes duration and weight loss are associated with onset age and remote metastasis of pancreatic cancer in patients with diabetes mellitus. [PDF]
J Diabetes, 2022 Highlights New‐onset diabetes and weight losses were common presentation and risk factors of early‐onset PC, which required more attention. Long‐term diabetes and heavy weight loss were risk factors contributing to distant metastases and less radical surgery, which needed to be better treated.
Ma M, Li W, Xu L, Ping F, Zhang H, Li Y.
europepmc +2 more sources
[Emphasizing Principles of Surgical Oncology in Minimally Invasive Surgery for Pancreatic Cancer]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban手术切除迄今为止仍是胰腺癌唯一的潜在根治手段，但胰腺癌手术也是所有恶性肿瘤手术中围手术期风险最高、远期预后最差的手术之一，这对外科医生形成了巨大挑战。近年来，胰腺手术在高流量中心的集中化、手术技术的进步以及围手术期管理水平的提高等显著降低了胰腺手术的围手术期并发症发生率与死亡率，同时外科医生也开始尝试将腹腔镜以及机器人辅助手术等微创手段应用于胰腺癌根治术，以期降低手术对患者造成的创伤，进一步加速患者康复，提高患者的生活质量。已有多项研究对比了微创胰腺切除手术与传统开放手术的围手术期安全性 ...
Gou S, Wu H.
europepmc +2 more sources
高表达的溶血卵磷脂酰基转移酶4促进胰腺癌细胞增殖的作用 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨溶血卵磷脂酰基转移酶4（LPCAT4）在胰腺癌中的表达水平及其对胰腺癌细胞增殖的影响。方法在本研究中，利用在线数据库LinkedOmics在线分析KRAS突变型与野生型胰腺癌患者差异表达基因，使用阿拉巴马大学伯明翰分校癌症数据分析（UALCAN），桑格生信分析平台（Sangerbox 3.0）和表达谱交互分析2（GEPIA2）分析LPCAT4在胰腺癌组织中的表达情况。使用Kaplan-Meier Plotter数据库探究LPCAT4与胰腺癌患者预后的相关性 ...
卢灏铭 +7 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1989 用人新鲜胰腺癌组织免疫BALB/c小鼠,取脾细胞与小鼠骨髓瘤细胞Sp2/0-Agl4融合,获得了分泌抗人胰腺癌单克隆抗体的杂交瘤细胞株。本文重点报道以ABC免疫组织化学法检查YPC1单克隆抗体与人正常组织和肿瘤组织的反应性。结果表明YPC1单克隆抗体与16例被检测的胰腺癌组织发生反应。其中9例(56.3％)呈强阳性反应,与23种正常组织中的10种(43.5％)以及19种非胰腺肿瘤中的8种(42.1％)有不同程度的交叉反应,但多数反应较弱。本研究提示以新鲜人体肿瘤组织作为免疫原制备单克隆抗体是简便可行的 ...
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Journal of Diabetes, Volume 13, Issue 12, Page 1007-1014, December 2021., 2021 Highlights This prospective study compares 15 patients with immune‐checkpoint induced diabetes mellitus (CPI‐DM) with a propensity score matched cohort of patients with other diabetes types. Diabetic ketoacidosis at onset and autoimmune comorbidity is more frequent in CPI‐DM patients. This can be avoided by regular glucose measurements and education on
Sascha R. Tittel +10 more
wiley +1 more source
Research progress on the mechanism of organ-specific lung metastasis in pancreatic cancer [PDF]
, 2023 Pancreatic cancer is a highly malignant tumor of the digestive system. Due to the non-specific clinical symptoms in the early stage, its early diagnosis is very difficult.
YUE Ming, WANG Liwei, CUI Jiujie
core +1 more source
Research progress of MDSCs-targeted immunotherapy for pancreatic cancer [PDF]
, 2023 Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
PENG Meiyu +4 more
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Effect of tRF-Pro-CGG on the biological behavior of mouse pancreatic cancer cells and its molecular mechanism [PDF]
, 2023 Background and purpose: tRNA-derived fragments (tRF) are a kind of short non-coding RNA (14-30 nt) that influences the course of cancer. This study aimed to investigate the molecular pathways that might underlie the effects of tRF-Pro-CGG on the ...
FU Qingsheng, JIN Lei, ZHANG Xudong, XU Yingchen, ZHU Chunfu, QIN Xihu, WU Baoqiang
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实用医学研究, 2019 目前，多数研究均提示新辅助治疗可提高肿瘤的根治性切除率并改善生存。多项大样本回顾性临床研究已凸显新辅助治疗的价值，各权威指南也越来越重视新辅助治疗在可切除胰腺癌中的作用，美国国家综合癌症网络（National Comprehensive Cancer Net- work，NCCN）指南将胰腺癌分类为可切除、交界可切除、局部进展、转移性胰腺癌。目前人们对新辅助治疗能改善部分胰腺癌患者（如交界可切除以及局部进展期胰腺癌患者）的预后已初步达成共识，但新辅助治疗在可切除胰腺癌中的应用价值仍存在争议，其方案选择 ...
馨雯 饶, 慷 杨
semanticscholar +1 more source
Leading research progress and prospect of antibody-drug conjugate in pancreatic cancer in 2022 [PDF]
, 2023 Pancreatic cancer is a type of malignant tumor with high incidence and low survival rate. It is urgent to develop novel and efficient therapeutic means for patients lacking surgical indications and patients with poor effects of radiotherapy and ...
ZENG Cheng, ZHANG Jian
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