Results 61 to 70 of about 4,486 (146)

线粒体在肿瘤能量代谢重编程中的研究进展

Zhongguo shiyan zhenduanxue
线粒体在细胞能量代谢、增殖、凋亡等过程中发挥关键作用，其功能异常与肿瘤的发生和发展密切相关。肿瘤细胞通过代谢重编程，优先依赖糖酵解而非氧化磷酸化来生成能量，这种现象称为“Warburg效应”。这种代谢方式为肿瘤细胞提供了增殖、转移所需的物质和能量基础。此外，线粒体功能的损伤导致能量供应不足，并促进了肿瘤细胞的生长和免疫逃逸。线粒体自噬作为一种细胞质量控制机制，通过去除受损线粒体来调节细胞能量代谢，其功能的异常可能促进肿瘤进展或增强化疗耐药性。线粒体自噬的作用在不同类型肿瘤中的影响复杂 ...
姜紫薇, 郎筠岚, 姚云祥, 张孟超   +3 more
doaj  

[Shihu Mixture alleviates diabetic cardiomyopathy in rats by Sirt3-mediated upregulation of myocardial mitochondrial mitophagy pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Lin X, He Y, Shi H, Liu J, Hu H.
europepmc   +1 more source

Progress in the effect of microRNA-21 on diseases via autophagy. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022
Zeng Z, Cai J, Liao Y, Sun S, Xie L.
europepmc   +1 more source

[EVA1A overexpression improves non-alcoholic fatty liver disease in mice by regulating lipid metabolism and promoting lipophagy]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Xu J, Yang D, Zang K, Chu M, Zhao Q, Li Q, Lu S, Chen X, Li N.   +8 more
europepmc   +1 more source

自噬参与氧化性低密度脂蛋白诱导的血管平滑肌细胞钙化

Zhongshan Daxue xuebao. Yixue kexue ban, 2010
【目的】 观察细胞自噬是否参与了氧化型低密度脂蛋白(Ox-LDL)诱导的血管平滑肌细胞钙化65377;【方法】 采用体外血管平滑肌细胞钙化模型,实验分为3组:control组:用native LDL处理细胞;Ox-LDL组:用Ox-LDL处理细胞;3MA组:用Ox-LDL和3MA处理细胞;细胞培养液为DMEM+10mM BGP65377;分别以茜素红检测血管钙化,Q-PCR 和Western blotting 测定cbfa1和Beclin1的mRNA 和蛋白表达65377;【结果】 Ox ...
doaj  

[Study on the role and mechanism of quercetin promoting autophagy in HCCLM3 cells via STING signaling]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Chen L, Wu GZ, Zhu Y, Zhang TT.
europepmc   +1 more source

镉暴露对肾细胞凋亡、自噬、氧化损伤及TGF-β1/Smad3/miRNAs信号通路的影响

Zhongguo shiyan zhenduanxue
目的 探讨镉（Cadmium, Cd）对人胚胎肾细胞293[human embryonic kidney（HEK） 293 cell line, HEK293]细胞凋亡、自噬、氧化损伤以及转化生长因子-β1（Transforming Growth Factor-beta 1,TGF-β1）/Smad同源物3（SMAD3）重组蛋白（Recombinant SMAD family member 3,Smad3）/微核糖核酸（microRNAs, miRNAs）信号通路的影响。方法 用氯化镉（Cadmium ...
刘仁洪, 黄月明, 樊婵, 易宗娓
doaj  

[Bioinformatics screening and analysis of key genes of ferroptosis and autophagy in alcoholic liver disease and their validation]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Zhang QQ, Zhang QQ, Zhang HY, Zhang RX, Liu LX.   +4 more
europepmc   +1 more source

Vitamin D/vitamin D receptor, autophagy, and infection. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022
Hou Y, Li J, Deng C.
europepmc   +1 more source

Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals. [PDF]

J Zhejiang Univ Sci B
Fan S, Chen Y, Yao W, Yi C.
europepmc   +1 more source