Results 41 to 50 of about 13,247 (207)
ABSTRACT Background Hazardous levels of contaminants produced by anthropogenic activities are increasingly pervading residential environs and urban areas. Hazardous contamination can pose significant health risks for citizens dwelling in exposure pathways.
Rosina Johnson +3 more
wiley +1 more source
目的基于癌症基因组图谱(TCGA)数据库食管鳞癌lncRNA差异表达,构建食管鳞癌预后风险模型。方法从TCGA肿瘤数据库下载食管鳞癌基因表达数据及临床信息,使用R 4.0.3软件提取差异表达lncRNA,进一步使用COX回归分析筛选模型lncRNA,并构建预后风险模型Riskscore;按照风险评分中位值将食管鳞癌患者分为低风险组和高风险组,进一步比较高低风险组生存预后;分析比较风险模型及其他临床特征对食管鳞癌生存预后的预测性能;分析风险评分与其他临床特征相关性;采用主成分分析(PCA)及基因富集分析 ...
蔡河源 +3 more
doaj
The epigenetic mechanism of imprinted gene IGF2 regulated by MEN1 in hepatocellular carcinogenesis [PDF]
原发性肝癌是肝细胞或肝内胆管上皮细胞发生的恶性肿瘤。死亡率仅次于胃癌和食道癌,其中肝细胞癌(hepatocellularcarcinoma,HCC)占原发性肝癌的90%。我们实验室围绕menin复合物调控的组蛋白甲基化与疾病发生关系开展了较系统深入的研究,证明了menin在肝细胞肝癌、非小细胞型肺癌及恶性黑色素瘤等非内分泌系统肿瘤中的重要生物学功能,阐明了menin调控组蛋白甲基化修饰的规律及机制。胰岛素样生长因子——2(insulinlikegrowthfactor2,IGF2 ...
丁丽红
core
ABSTRACT Sepsis is a leading cause of mortality in the United States, with over 350,000 deaths annually, yet the contribution of neighborhood‐level social determinants of health (SDoH) remains underexplored. We conducted a retrospective analysis of 4.4 million hospitalized patients with sepsis, identified using ICD‐10 codes, leveraging de‐identified ...
Ahad Khaleghi Ardabili +3 more
wiley +1 more source
Research on the Pricing of China MBS under the Condition of Interest Rate Liberalization [PDF]
作为金融领域的重大创新之一,住房抵押贷款支持证券(Mortgage-BackedSecuritization,MBS)在我国兴起十多年来,不仅盘活了存量资金,也为资本市场注入新的活力。近年,我国利率市场化的基本完成也为MBS业务提供了资金动力,使其进入常态化。产品定价作为MBS发行的关键环节,它的合理与否直接关系着资产证券化产品能否顺利发行与交易。 国外MBS发展较早,已经形成较成熟完善的定价体系。我国MBS业务尚处于发展阶段,定价的相关研究主要集中在发展障碍、政策建议的理论分析方面 ...
刘丽娜
core
Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault +6 more
wiley +1 more source
Integrated Risk Management into Project Decision Making Model: Based on E-Scooter Anti-Lock R&D Project of X Group [PDF]
“十二五”规划确立了中国制造业“加快产业结构调整、由制造业低端向高端转变”的发展策略,改革创新成为众多中国企业不愿做却又不得不做的事。研究显示创新项目的成功率很低,而且不少项目产品表现不佳,给企业带来严重的亏损。 本文目标是希望通过对项目决策过程的研究,使更多创新项目能够借助集成风险管理的决策模型来提高项目成功率,或及时终止前景不佳的项目。论文的主要研究内容包括X集团的两轮车防抱死研发项目决策模型,内外部环境的风险管理规划、动态风险的监控及预警,以及风险分析工具诸如敏感性分析 ...
胡南
core
ABSTRACT Objectives To compare the maternal hemodynamics of Chinese women at low and at high risk for preterm pre‐eclampsia (PE) and assess the differences in hemodynamic parameters between high‐risk women with or without prophylactic aspirin. Methods This was a prospective longitudinal case–control study of 857 Chinese women with a singleton pregnancy
X. Wang +11 more
wiley +1 more source
Risk Management and Control Issues for Service Outsourcing in Logistics Support Industry [PDF]
摘要 服务外包作为一种现代新兴产业,适应了目前全球经济一体化,社会分工细致化的趋势,成为当下学术研究的热点和企业实践争相仿效的对象。但是在服务外包的实务中暴露出的许多风险监控的漏洞和难点,也成为了进一步推进我国服务外包产业发展深度和广度的瓶颈。 作为我国国民经济支柱的物流辅助业的服务外包问题研究也是近年来的业内降低成本,提升企业核心竞争力的竞争策略筹划的新趋势,虽然起步较晚,但是由于行业本身的涉外程度较高,所以推进速度很快。有感于此,本文从服务外包的发包企业的角度出发 ...
吴文燕
core
ABSTRACT Objective To evaluate the impact of low‐dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA‐PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early‐onset pre‐eclampsia (PE).
C. Trilla +7 more
wiley +1 more source

