Results 131 to 140 of about 10,198,141 (356)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Impregnated Teflon as a Packing Material at 150 000 Pounds per Square Inch [PDF]

, 1956
H. A. Bowman, J. Cross, D. P. Johnson, J. D. Hill, J. S. Ives   +4 more
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

The Effect of Multiple Formats on Understanding Complex Visual Displays [PDF]

, 2007
Provides pedagogical insight concerning the skill of contours The resource being annotated is: http://www.dlese.org/dds/catalog_DLESE-000-000-004-595 ...
Lamont-Doherty Earth Observatory, Columbia University
core  

Interactive-engagement vs traditional methods: A six-thousand-student survey of mechanics test data for introductory physics courses [PDF]

, 2003
The complete report from Richard Hake's long-term study of interactive engagement (IE) techniques and their effect on the understanding of physics by non-physics majors.
Richard Hake
core   +1 more source

Systematics of parton fragmentation in $e^+$-$e^-$ and nuclear collisions [PDF]

arXiv, 2009
Parametrizations of fragmentation functions (FFs) from $e^+$-$e^-$ and p-\=p collisions are combined with a parton spectrum model in a pQCD folding integral to produce minimum-bias {\em fragment distributions}. A model of in-medium FF modification is included. Calculated fragment distributions are compared with {\em hard components} from p-p and Au-Au $
arxiv  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Classtalk: A Classroom Communication System for Active Learning [PDF]

, 1996
This pdf file is an article describing the advantages of using Classtalk technology in the classroom to enhance classroom communication. Classtalk technology cab facilitate the presentation of questions for small group work, collec the student answers ...
A. Heuvelen Van, A.P. Lightman, C.C. Bonwell, C.S. Claxton, C.W. Anderson, D. Hestenes, D. Hestenes, D.H. Jonassen, D.R. Sokoloff, D.W. Johnson, E. Glasersfeld von, E. Glasersfeld von, E. Mazur, E. Seymour, G.D. Stetten, I.A. Halloun, J. Lave, J. Mestre, J. Wilson, J.H. Larkin, J.H. Larkin, J.H. Larkin, J.H. Wandersee, J.J. Clement, J.J. Clement, J.S. Brown, Jose P. Mestre, K. Tobin, K.A. Strike, L. Schauble, L.B. Resnick, L.B. Resnick, L.C. McDermott, L.S. Vygotsky, Laura Wenk, M. Cole, M.M. Gullette, M.T.H. Chi, P.M. Sadler, P.R. Pintrich, P.R. Pintrich, P.R. Pintrich, P.W. Hewson, R. Dufresne, R. Garner, R. Glaser, R. Glaser, Robert J. Dufresne, S. Tobias, William J. Gerace, William J. Leonard, Y. Anzai   +51 more
core   +1 more source

A picture paints 5 000 (pages of) words

South African Journal of Radiology, 2000
No abstract available.
Russel Whitehorn
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source