Results 111 to 120 of about 13,327,440 (231)

Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): Aquation, redox properties, protein binding, and antiproliferative activity [PDF]

, 2007
Imidazolium [trans-tetrachloro(1H-imidazole)(S-dimethylsulfoxide) ruthenate(III)] (NAMI-A) and indazolium [trans-tetrachlorobis(1H-indazole) ruthenate(III)] (KP1019) are the most promising ruthenium complexes for anticancer chemotherapy.
Timerbaev, Andrei R., Jakupec, Michael A., Arion, Vladimir B., Reisner, Erwin, Eichinger, Rene, Semenova, Olga, Grössl, Michael, Groessl, Michael, Keppler, Bernhard K., Hartinger, Christian G.   +9 more
core   +1 more source

Synthesis, structure and properties of N-R-amides and hydrazides of 2-[4-R-5-(theophylline-7ʹ-yl)-1,2,4-triazole-3-ylthio]acetic acid

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
One of the most important tasks of modern pharmaceutical science is the search for new biologically active substances, which have high efficacy and low toxicity.
A. S. Gotsulya
doaj   +1 more source

Synthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1,2,4-Triazol-3-thiols and their S-substituted Derivatives.

Iranian journal of pharmaceutical research : IJPR, 2015
The thiosemicarbazides 3a-c were appeared by reaction of the corresponding substituted hydrazides 1a-c with allylisothiocyanate 2. Synthesis of some novel 1,2,4-triazole-thiols 4a-c bearing a pyridyl unit using 1-(x-picolinoyl)-4-allyl-thiosemicarbazides (x = 2,3,4) in an alkaline solution, is reported.
Kalhor, Mehdi, Shabani, Mahboobeh, Nikokar, Iraj, Banisaeed, Seyedeh Reyhaneh   +3 more
openaire   +2 more sources

Synthesis, structure, physicochemical properties and antibacterial activity of 1,2,4-triazoles-3-thiols and furan derivatives

Voprosy Khimii i Khimicheskoi Tekhnologii, 2019
Зажарський Володимир Володимирович https://orcid.org/0000-0003-2674-2494 Давиденко Павло Олександрович https://orcid.org/0000-0002-8425-3835 Кулішенко Олег Миколайович https://orcid.org/0000-0001-6801-2380 Зажарська Надія Миколаївна https://orcid.org/0000-0002-8328-6440 Боровик Ірина Володимирівна https://orcid.org/0000-0001-5958 ...
openaire   +1 more source

Synthesis methods of 1,2,4-triazole-3-thiones: review [PDF]

1,2,4-Triazole-containing compounds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in drug-discovery studies against cancer cells, microbes, and various types of diseases in the human ...
T. V. Ihnatova, Yu. S. Frolova, A. H. Kaplaushenko, T. M. Kaplaushenko   +3 more
core   +2 more sources

Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives of Salicylic Acid and its Synthetic Intermediates [PDF]

, 2015
Eight compounds 2–9 have been synthesized starting from salicylic acid, two of them (7 and 9) are novel. The four final products namely: 5-(2-hydroxy phenyl)-1,3,4-oxadiazole-2-thione 4, 3-(2-hydroxy phenyl)-1H-1,2,4-triazole-5-thiol 6, 3-(2-hydroxy ...
Khiati, Z, Guessas, B, Othman, AA
core   +1 more source

Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Most pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. Furthermore, during biotransformation, they may generate one or more metabolites with potent bioactive properties.
Yu. V. Karpenko, O. I. Panasenko, A. P. Litun   +2 more
doaj   +1 more source

Synthetic Strategies of Fused Triazole Frameworks: A Comprehensive Review. [PDF]

ACS Omega
Tamminana R, Mohammed A.
europepmc   +1 more source

New indole-linked 1,2,4-triazole derivatives as dual FAK inhibitors and apoptosis inducers targeting survival and migration in triple-negative breast cancer in-vitro. [PDF]

Sci Rep
Abd El Salam HA, Abu-Shahba N, Ibrahim Fouad G, Mahmoud M, Mostafa EA, Abozeid MAM, Abo-Salem HM, Azouz RAM.   +7 more
europepmc   +1 more source

Rational design and synthesis of Co(ii), Ni(ii) and Cu(ii) complexes bearing 1,2,4-triazole scaffold for biological applications. [PDF]

RSC Adv
Hassoon AA, Abulkhair HS, Ashour RH, Abdelsamea MM, Abdullah HO, Eldesoky MA, Shaban AR, John P, Ghaith EA.   +8 more
europepmc   +1 more source