Results 121 to 130 of about 669 (167)

A facile access to bridged 1,2,4-trioxanes

Tetrahedron, 2006
Abstract Bicyclo[3.2.1] type 1,2,4-trioxanes are readily synthesized from precursors that may form intramolecular hemiketals using UHP (H 2 O 2 –urea complex) as the source of the peroxy bond and p -TsOH or CSA as the catalyst. The ring closure through an intramolecular Michael addition occurred in a highly stereoselective way, giving only one ...
Qi Zhang, Hong-Xia Jin, Yikang Wu
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Thermolysis and Chemiluminescence of Monocyclic 1,2,4‐Trioxan‐5‐ones

Helvetica Chimica Acta, 1994
AbstractThe 3,6‐substituted 1,2,4‐trioxan‐5‐ones 11–14, on heating to 170–200°, underwent unimolecular thermolysis to generate electronically excited singlet ketones with an efficiency of ca. 0.2%. The chemiluminescence quantum yields (ϕoSCL) depended on the nature of the 6‐substitutents and increased linearly with temperature. The Arrhenius activation
Jefford, Charles, Josso, Martin, Vicente, Maria Da Graca Henriques, Hagemann, Hans-Rudolf, Lovy, Dominique, Bill, Hans   +5 more
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Synthesis of 1,2,4-trioxanes via intramolecular oxymercuriation

Journal of the Chemical Society, Chemical Communications, 1991
3-Alkyl- and 3-aryl-5,5,6,6-tetramethyl-1,2,4-trioxanes 5 are prepared by reduction of the corresponding 5-bromomercuriomethyl compounds 4 obtained, after anion exchange, by intramolecular oxymercuriation of the hemiperacetals 3 formed from aldehydes and 2,3-dimethylbut-1-en-3-yl hydroperoxide 2; a ‘one pot’ procedure omitting the anion exchange and ...
A. J. Bloodworth, Aneela Shah
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ChemInform Abstract: CHEMILUMINESCENT 5‐ARYLAMINO‐1,2,4‐TRIOXANES

Chemischer Informationsdienst, 1977
AbstractZur Herstellung cheniilumineszierender 5‐Arylamino‐1 ,2,4‐trioxane (V), deren Wirkungsmechanismen diskutiert werden, werden die Amine (I) mit Isobutyraldehyd (II) zu den Anilen (III) umgesetzt.
T. GOTO, H. NAKAMURA
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The thermal decomposition of some 1,2,4-trioxanes

Thermochimica Acta, 1991
Chemists generally believe that the O-O bond of the peroxide function is inherently unstable: In fact, many peroxides readily decompose on heating [l]. By analogy, 1,2,4-trioxanes which are cyclic peroxides, would also be expected to be equally thermally unstable.
Jefford, Charles, Jaber, Amer, Boukouvalas, John, Tissot, Paul   +3 more
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Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment

Journal of Medicinal Chemistry, 2012
A new series of bile acid-based trioxanes 23a-d, 24a-d, 25a-d, 26a, 26b, and 26d have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. The antimalarial activity of these trioxanes showed a strong dependence on the side-chain length; shortening side-chain length lead
Chandan, Singh, Mohammad, Hassam, Ved Prakash, Verma, Ajit Shanker, Singh, Niraj Krishna, Naikade, Sunil K, Puri, Prakas R, Maulik, Ruchir, Kant   +7 more
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Synthesis of New 1,2,4‐Trioxanes and their Antimalarial Activity

Helvetica Chimica Acta, 1988
AbstractThe three dihydronaphtho[1,2,4]trioxines 9–11 have been synthesized and two of them converted to the five carbamate and ester derivatives 12–16 (Schemes 1 and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensitive N strain of Plasmodium berghei in mice.
Jefford, Charles, McGoran, Ernest C., Boukouvalas, John, Richardson, Geoffrey David, Robinson, Brian L., Peters, Wallace   +5 more
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Novel Spiroanellated 1,2,4‐Trioxanes with High in vitro Antimalarial Activities.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Axel G, Griesbeck, Tamer T, El-Idreesy, Lars-Oliver, Höinck, Johann, Lex, Reto, Brun   +4 more
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Synthesis and reactions of 5-arylamino-1,2,4-trioxans

Journal of the Chemical Society, Perkin Transactions 1, 1980
Eleven 5-arylamino-1,2,4-trioxans were synthesized by the reaction of arylamines, e.g., aniline, toluidines, xylidines, or mesitylamine, with aldehydes, e.g., 2-methylpropanal or 2-phenylpropanal, in the presence of atmospheric oxygen. The structures of these trioxans were proved to be similar to that of 5-(1-naphthylamine)-1,2,4-trioxan, determined by
Hiroshi Yamamoto, Masamoto Akutagawa, Hiromu Aoyama, Yoshimori Omote   +3 more
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Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy

Drug Resistance Updates, 2005
In addition to their well-known anti-malarial activity, artemisinin and its derivatives (1,2,4-trioxanes) possess potent activity against tumor cells in the nano- to micromolar range. Candidate genes that may contribute to the sensitivity and resistance of tumor cells to artemisinins were identified by pharmacogenomic and molecular pharmacological ...
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