Results 101 to 110 of about 669 (167)

Phosphite ozonides as singlet oxygen sources for organic synthesis and the preparation of novel endoperoxide-containing antimalarials [PDF]

Rawe, Sarah-Louise
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Contemporary approaches to malaria chemotherapy : novel quinoline and peroxide-based antimalarial frugs [PDF]

Mukhtar, Amira
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An evaluation of the cytotoxicity of the dihydroartemisinin-acridine hybrids and tetra-oxane dimmers against leukaemia and colon cancer cells lines ‘1’ [PDF]

, 2013
Rinki, Rinki
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Synthesis of 1,2,4-trioxanes with antimalarial activity

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New orally active spiro 1,2,4-trioxanes with high antimalarial potency

Bioorganic and Medicinal Chemistry Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Chandan, Singh, Heetika, Malik, Sunil K, Puri   +2 more
exaly   +3 more sources

Piperidine dispiro-1,2,4-trioxane analogues

Bioorganic & Medicinal Chemistry Letters, 2008
Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently used to prepare derivatives (4-7 ...
Sunil, Sabbani, Paul A, Stocks, Gemma L, Ellis, Jill, Davies, Erik, Hedenstrom, Stephen A, Ward, Paul M, O'Neill   +6 more
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6-hydroxymethyl-1,2,4,-trioxanes and derivatives : An alternative 1,2,4-trioxane synthesis from β′γ′-unsaturated β-hydroxyhydroperoxides

Tetrahedron Letters, 1994
Abstract Allylic hydroperoxides CH 2 :C(Ph)CH(OOH)CH 2 OX (X  H, CONHPh, Ac), from regiospecific photooxygenation of allylic alcohols CH 3 C(Ph):CHCH 2 OX, form hemiperoxyacetals with aldehydes or ketones which upon cyclisation with mercury(II) trifluoroacetate then reduction with sodium borohydride diastereoselectively afford 1,2,4-trioxanes with ...
A.J. Bloodworth, Karen A. Johnson
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Synthesis of 1,2,4-trioxans

Journal of the Chemical Society, Chemical Communications, 1981
The reaction of a mixture of α-hydroxydecyl hydroperoxide [or bis(α-hydroxyalkyl) peroxides] and epoxides in the presence of tungstic anhydride and catalytic amounts ofchlorosulphonic acid gave the corresponding 1,2,4-trioxans in 7–63% yield.
Masahiro Miura, Masatomo Nojima, Shigekazu Kusabayashi   +2 more
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1,2,4-Trioxanes as potential antimalarial agents

Journal of Medicinal Chemistry, 1988
A number of 1,2,4-trioxanes were prepared and tested for antimalarial activity in search of a simplified analogue of the naturally occurring antimalarial qinghaosu. The compounds were assayed in an in vitro system for antimalarial activity against chloroquine-susceptible and chloroquine-resistant strains of Plasmodium falciparum.
J A, Kepler, A, Philip, Y W, Lee, M C, Morey, F I, Carroll   +4 more
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