Results 21 to 30 of about 3,889 (119)

The Photochemical Mediated Ring Contraction of 4H-1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2H)-one 1-Oxides

, 2023
1,2,6-Thiadiazines treated with visible light and 3O2 under ambient conditions are converted into difficult-to-access 1,2,5-thiadiazole 1-oxides (35 examples, yields of 39–100%).
Andreas S. Kalogirou (10525348), Brendan Gallagher (16404786), Christopher G. Thomson (16963710), Emmanouil Broumidis (16963707), Filipe Vilela (1266402), Gareth Lloyd (17162290), Georgina M. Rosair (628281), Janet E. Lovett (2045767), Kenneth G. McKendrick (1271511), Lia Sotorríos (17752464), Martin J. Paterson (1235301), Panayiotis A. Koutentis (1278807), Stuart A. Macgregor (1350846)   +12 more
core   +2 more sources

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

Studies on Chemical Entities of Pharmaceutical Interest [PDF]

, 2007
Not ...
Shukla, Bhavin S.
core  

Búsqueda y optimización de potenciales alternativas terapéuticas para el tratamiento de la enfermedad de chagas [PDF]

, 2016
La enfermedad de Chagas, causada por Trypanosoma cruzi, es una parasitosis endémica en 21 países de América Latina, donde se transmite por las heces contaminadas de triatominos, provoca más de 7.000 muertes anuales y cerca de 25 millones de personas ...
Fonseca Berzal, Cristina Rosa
core   +1 more source

Synthesis of 1,2,6-Thiadiazin 1,1-Dioxide Derivatives as Trypanocidal Agents [PDF]

Molecules, 2000
It describes the synthesis of new 1,2,6-Thiadiazin 1,1-dioxide derivatives using condensation of the Knoevenagel type. The products are evaluated in vitro as trypanocidal agents.
Cerecetto, H., Maio, R. Di, Seoane, G., Ochoa, C., Gómez-Barrio, A., Muelas, S.   +5 more
openaire   +2 more sources

N-glucosyl-5-amino-4-carbamoyl- and 4-ethoxycarbonylimidazoles as potential precursors of 4-oxoimidazo[4,5-c]-1,2,6-thiadiazine 2,2-dioxides

, 1986
Synthese des imidazoles du titre; leur reaction avec ClSO 2 NH 2 (A) n'a pas conduit aux imidazo thiadiazines desirees; synthese de dioxydes-2,2 d'alkyl-7 tetrahydro-1,3,4,7 oxo-4 imidazo [4,5-c] thiadiazines-1,2,6 a partir de A et d'alkyl-1 amino-2 ...
P. Goya, Alfredo Martínez
semanticscholar   +1 more source

The Acid and/or Thermal Mediated Ring Contraction of 4H‑1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazoles

A near-quantitative acid and/or thermal mediated ring contraction of 3′,5′-diarylspiro­(benzo­[d]­[1,3]­dioxole-2,4′-[1,2,6]­thiadiazines) affords 3-aryl-4-(2-arylbenzo­[d]­[1,3]­dioxol-2-yl)-1,2,5-thiadiazoles.
Andreas S. Kalogirou (1546180), Andreas Kourtellaris (1693780), Panayiotis A. Koutentis (1278807)   +2 more
core   +5 more sources

New chemistry of isothiazoles and 1,2,6-thiadiazines

, 2011
This thesis begins with a short introduction on heterocyclic chemistry as well as the known chemistry of isothiazoles and 1,2,6-thiadiazines. The main part is then divided into 3 parts (Chapters 2, 3 and 4 are Part 1, Chapters 5, 6 and 7 are part 2 and part 3 is chapter 8). In the first part, the regioselective dehalogenation of 3,5-dihaloisothiazole-4-
Ioannidou, Heraklidia A., Ioannidou, Heraklidia A.   +1 more
openaire   +1 more source

Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease. [PDF]

ACS Med Chem Lett, 2020
Terrab L, Rosenker CJ, Johnstone L, Ngo LK, Zhang L, Ware NF, Miller B, Topacio AZ, Sannino S, Brodsky JL, Wipf P.   +10 more
europepmc   +1 more source

A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome. [PDF]

Int J Mol Sci, 2020
Na YJ, Choi KJ, Jung WH, Park SB, Kang S, Ahn JH, Kim KY.   +6 more
europepmc   +1 more source