Results 11 to 20 of about 3,889 (119)

Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors. [PDF]

Molecules, 2021
A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from previous kinase inhibitor programs were used to carefully select several different substitution ...
Kalogirou AS, East MP, Laitinen T, Torrice CD, Maffuid KA, Drewry DH, Koutentis PA, Johnson GL, Crona DJ, Asquith CRM.   +9 more
europepmc   +3 more sources

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity. [PDF]

Sci Rep, 2020
International audienceTrematode infections such as schistosomiasis and fascioliasis cause signifcant morbidity in an estimated 250 million people worldwide and the associated agricultural losses are estimated at more than US$ 6 billion per year.
Ferraro F, Corvo I, Bergalli L, Ilarraz A, Cabrera M, Gil J, Susuki BM, Caffrey CR, Timson DJ, Robert X, Guillon C, Freire T, Álvarez G.   +12 more
europepmc   +5 more sources

Nitrogen-Containing Molecules: Natural and Synthetic Products Including Coordination Compounds [PDF]

, 2022
A total of 16 original research articles. Contributions from 10 countries from 3 continents. Organic synthesis towards novel heterocyclic compounds.

core   +1 more source

3,5-Bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one

Molbank, 2012
3,5-Dichloro-4H-1,2,6-thiadiazin-4-one 1 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 4 (2.2 equiv.) and Pd(Ph3P)2Cl2 (5 mol%) in acetonitrile at ca. 82 °C to give 3,5-bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one 5 in 93% yield.
Panayiotis A. Koutentis, Heraklidia A. Ioannidou   +1 more
doaj   +1 more source

3-Chloro-5-(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one

Molbank, 2012
3-Chloro-5-trifluoromethanesulfonate-4H-1,2,6-thiadiazin-4-one 3 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 5 (1 equiv.) in the presence of Pd(Ph3P)2Cl2 (5 mol%) in benzene at ca.
Panayiotis A. Koutentis, Heraklidia A. Ioannidou   +1 more
doaj   +1 more source

Photoactive materials enabled by and for emerging synthetic technologies [PDF]

, 2022
In recent years there has been a significant increase in the development and commercialisation of new synthetic tools and technologies, which offer significant advantages compared to traditional round-bottomed flask chemistry.
Broumidis, Emmanouil
core  

Photochemical Ring Editing: Access to Privileged 1,2,5-Thiadiazole Scaffolds via Efficient Carbon Excision from Thiadiazines Under Ambient, Aerobic Conditions

, 2022
Thiadiazoles are a privileged motif in medicinal chemistry, however selective mono-oxidation of the endocyclic sulfur, without over oxidation, is challenging.
Andreas S., Kalogirou, Brendan, Gallagher, Christopher G., Thomson, Emmanouil, Broumidis, Filipe, Vilela, Gareth O., Lloyd, Georgina M., Rosair, Janet E., Lovett, Kenneth G., McKendrick, Lia, Sotorríos, Martin J., Paterson, Panayiotis A., Koutentis, Stuart A., Macgregor   +12 more
core   +1 more source

The Photochemical Mediated Ring Contraction of 4H‑1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2H)‑one 1‑Oxides

, 2023
1,2,6-Thiadiazines treated with visible light and 3O2 under ambient conditions are converted into difficult-to-access 1,2,5-thiadiazole 1-oxides (35 examples, yields of 39–100%).
Andreas S. Kalogirou (10525348), Brendan Gallagher (16404786), Christopher G. Thomson (16963710), Emmanouil Broumidis (16963707), Filipe Vilela (1266402), Gareth O. Lloyd (1235277), Georgina M. Rosair (628281), Janet E. Lovett (2045767), Kenneth G. McKendrick (1271511), Lia Sotorríos (8114585), Martin J. Paterson (1235301), Panayiotis A. Koutentis (1278807), Stuart A. Macgregor (1350846)   +12 more
core   +1 more source

Scientific Opinion of Flavouring Group Evaluation 406 (FGE.406): (S)‐1‐(3‐(((4‐amino‐2,2‐dioxido‐1H‐benzo[c][1,2,6]thiadiazin‐5‐yl)oxy)methyl)piperidin‐1‐yl)‐3‐methylbutan‐1‐one

EFSA Journal, Volume 16, Issue 2, February 2018., 2018
Abstract The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) of EFSA was requested to deliver a scientific opinion on the safety of the use of the substance (S)‐1‐(3‐(((4‐amino‐2,2‐dioxido‐1H‐benzo[c][1,2,6]thiadiazin‐5‐yl)oxy)methyl)piperidin‐1‐yl)‐3‐methylbutan‐1‐one [FL‐no: 16.129], as a flavouring substance.
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Vittorio Silano, Claudia Bolognesi, Laurence Castle, Kevin Chipman, Jean‐Pierre Cravedi, Karl‐Heinz Engel, Paul Fowler, Roland Franz, Konrad Grob, Rainer Gürtler, Trine Husøy, Sirpa Kärenlampi, Maria Rosaria Milana, Karla Pfaff, Gilles Riviere, Jannavi Srinivasan, Maria de Fátima Tavares Poças, Christina Tlustos, Detlef Wölfle, Holger Zorn, Ulla Beckman Sundh, Romualdo Benigni, Mona‐Lise Binderup, Leon Brimer, Francesca Marcon, Daniel Marzin, Pasquale Mosesso, Gerard Mulder, Agneta Oskarsson, Camilla Svendsen, Jan Van Benthem, Maria Anastassiadou, Maria Carfì, Wim Mennes   +36 more
wiley   +1 more source

1,2,6-Thiadiazine 1-Oxides: Unsaturated Three-Dimensional S,N-Heterocycles from Sulfonimidamides [PDF]

Organic Letters, 2020
Unprecedented three-dimensional 1,2,6-thiadiazine 1-oxides have been prepared by an aza-Michael-addition/cyclization/condensation reaction sequence starting from sulfonimidamides and propargyl ketones. The products have been further functionalized by standard cross-coupling reactions, selective bromination of the heterocyclic ring, and conversion into ...
Schöbel, Jan-Hendrik, Passia, Marco Thomas, Wolter, Nadja Anna, Puttreddy, Rakesh, Rissanen, Kari, Bolm, Carsten   +6 more
openaire   +4 more sources