Results 161 to 170 of about 300,590 (210)
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A sensitive and simplified radioimmunoassay for 1,25-dihydroxyvitamin D3
Clinica Chimica Acta, 1984A sensitive radioimmunoassay system for 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] with an improved extraction procedure has been developed. Following one-step extraction and prepurification of 1,25(OH)2D3 by 'Extrelut-1' minicolumns final purification was achieved by high-performance liquid chromatography (HPLC) using a radial compression separation
S, Scharla +3 more
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Localized scleroderma-response to 1,25-dihydroxyvitamin D3
Clinical and Experimental Dermatology, 19901,25-Dihydroxyvitamin D3 [1,25(OH)2 D3] may be an immunomodulatory drug which could have a role in controlling collagen deposition, and inducing reversal of fibrosis in some tissues. These observations prompted a study of the possible use of this hormone for the treatment of scleroderma.
P G, Humbert +6 more
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Immunomodulatory actions of 1,25-Dihydroxyvitamin D3
The Journal of Steroid Biochemistry and Molecular Biology, 1995The sterol, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), has immunosuppressive activity. The hormone inhibits the production of lymphokines (IL-2, IFN-gamma) and monocyte-derived cytokine (IL-12) leading to inhibition of helper T cell subset type 1 (Th1).
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1,25-Dihydroxyvitamin D3 receptors in mouse colon
Journal of Steroid Biochemistry, 1981Mouse colon possesses a cytoplasmic receptor-like binder for 1,25-dihydroxy vitamin D3 which appears similar to the receptors previously described in other more classical target organs. The properties of this receptor include a sedimentation coefficient of 3.2S in sucrose gradients prepared in 0.3 M KCl, an equilibrium dissociation constant of 0.2 nM ...
M A, Hirst, D, Feldman
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Intestinal absorption of 1,25-dihydroxyvitamin D3 in the rat
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1985Intestinal absorption of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] from in vivo jejunal sacs was studied in rats with thoracic duct and bile duct cannulas. In 6 h 86.5% of the administered 1,25(OH)2D3 was absorbed, but only 7.3% was recovered in thoracic duct lymph.
M D, Sitrin, K L, Pollack, M J, Bolt
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1,25-Dihydroxyvitamin D3 and the regulation of macrophage function
Calcified Tissue International, 1981Vitamin D3 deficient (D-) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D- mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D- mice can be corrected by incubation with 1,25 ...
Z, Bar-Shavit +5 more
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Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
The Journal of Steroid Biochemistry and Molecular Biology, 20051,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells.
Evelyne, van Etten, Chantal, Mathieu
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Specific binding of 1,25 dihydroxyvitamin D3 in lymphocytes
Metabolism, 1984We examined ten cellular or tissue sources of lymphocytes for specific binding of 1,25(OH)2D3, the hormonally active form of vitamin D3. A specific-binding protein was found in three of these sources. Scatchard analysis of cytosol from a follicular lymphoma cell line revealed binding sites with a Kd of 7.0 X 10(-11) and a receptor concentration of 6.6 ...
R M, Walter +4 more
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Interactions of 1,25-dihydroxyvitamin D3 and the immune system
Molecular and Cellular Endocrinology, 1985A series of recent discoveries indicate that the hormonal form of vitamin D3, namely, 1,25(OH)2D3 plays a role in the regulation of the immune system. Cells of the monocyte/macrophage lineage possess receptors for 1,25(OH)2D3 regardless of their activation stage; cells of the lymphoid lineage also express these receptors but only at certain stages of ...
S C, Manolagas +2 more
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An immunoradiometric assay for 1,25-dihydroxyvitamin D3 receptor
Analytical Biochemistry, 1989A ligand-independent, quantitative assay has been developed for the measurement of 1,25-dihydroxyvitamin D receptor utilizing purified receptor from pig intestine as a standard and two high affinity monoclonal antibodies directed to two different epitopes on the receptor.
M E, Sandgren, H F, Deluca
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