Results 41 to 50 of about 2,500 (166)

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

Recovery of Liquid Organic Radioactive Waste Absorbed Into Soil by Extraction

CleanMat, Volume 2, Issue 4, Page 285-296, December 2025.
Radioactive organic liquid waste adsorbed in soil containing pure beta‐emitting radionuclides such as H‐3 must be radiologically characterized for subsequent management. For this purpose, a method for the recovery of radioactive scintillation liquids adsorbed in soil has been developed that simulates this type of waste.
Fabiola Monroy‐Guzman, Yurihelem Jacobo Cruz, Thelma Selene Jiménez Bravo, Ignacio Alfredo Rivero Espejel, Jorge Anguiano Arévalo, María Dolores Tenorio Castillejos   +5 more
wiley   +1 more source

Synthesis, Spectral Characterization and Biocidal Studies of Copper(II) Complexes of Chromen-2-one-3-carboxy Hydrazide and 2-(Chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole Derivatives

E-Journal of Chemistry, 2011
Copper(II) complexes of chromen-2-one-3-carboxyhydrazide and 2-(chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, molar ...
Glory Mathew, R. Krishnan, Molly Antony, M. S. Suseelan   +3 more
doaj   +1 more source

5-(3-Hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione hemihydrate

IUCrData, 2019
The title 1,3,4-oxadiazole derivative crystallizes as a hemihydrate, C8H6N2O2S·0.5H2O, with the water molecule located on a twofold rotation axis. The 1,3,4-oxadiazole molecule is essentially planar, the r.m.s. deviation of the non-H atoms being 0.0443 Å.
Surayyo Razzoqovna Razzoqova, Shaxnoza Kadirova, Jamshid Mengnorovich Ashurov, Dilnoza Salamovna Rakhmonova, Abdukhakim Ziyaev, Nusrat Agzamovich Parpiev   +5 more
doaj   +1 more source

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The title compound, C(15)H(12)N(2)O, adopts the expected near-planar geometry, the phenyl and tolyl rings being inclined relative to the oxadiazole ring by 3.8 (3) and 8.3 (2)°, respectively. This allows adjacent mol-ecules to pack in a parallel fashion and form stacking along [010] via π-π inter-actions [centroid-centroid distances = 3.629 (2) and 3 ...
Cordes, David B., Hua, Guoxiong, Slawin, Alexandra M. Z., Woollins, J. Derek   +3 more
openaire   +5 more sources

Multi‐channel charge transfer delayed fluorescence enabling high‐efficiency organic light‐emitting diodes

FlexMat, Volume 2, Issue 4, Page 533-581, December 2025.
The enhanced utilization of triplet excitons is a central theme in the evolution of organic luminescent materials. This review sums up recent research on multi‐channel charge transfer delayed fluorescence molecules, which exhibit a unique distribution of excited‐state energy levels, thereby enhancing the utilization rate of triplet excitons and ...
Guo‐Wei Chen, Zhen Zhang, Xin‐Yi Zeng, Yi‐Hui He, Guo Yuan, Yan‐Qing Li, Jian‐Xin Tang   +6 more
wiley   +1 more source

Synthesis and antimicrobial evaluation of some 2,5 disubstituted 1,3,4-oxadiazole derivatives

Research in Pharmaceutical Sciences, 2017
1,3,4-oxadiazoles are interesting compounds because of their valuable biological effects such as cytotoxic, antibacterial, antifungal, and anti-tubercular activities.
Elham Jafari, Tahereh Mohammadi, Ali Jahanian-Najafabadi, Farshid Hassanzadeh   +3 more
doaj   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, Volume 12, Issue 42, November 13, 2025.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

Diazole and triazole derivatives of castor oil extract: synthesis, hypoglycemic effect, antioxidant potential and antimicrobial activity

Grasas y Aceites, 2020
The ricinoleate triglyceride was extracted from castor-oil seeds grown in Algeria and isolated by catalytically methanolyse to methyl ricinoleate.
F. Taieb Brahimi, F. Belkhadem, B. Trari, A. A. Othman   +3 more
doaj   +1 more source

Identification of New CD36 Antagonists by Structure‐Based Virtual Screening

Chemical Biology &Drug Design, Volume 106, Issue 5, November 2025.
Virtual screening identified drug‐like molecules as potential CD36 antagonists; some of them inhibited CD36 function in relevant cellular models. These antagonists could drive the development of CD36‐targeted therapies. ABSTRACT CD36 is a transmembrane glycoprotein that facilitates the uptake of fatty acids and oxidized low‐density lipoproteins.
Sandra L. Guerrero‐Rodríguez, Luis Córdova‐Bahena, Fabiola Cortés‐Mendoza, Angel J. Ruiz‐Moreno, Cecilia Mata‐Cruz, Mireya Velázquez‐Paniagua, Nohemí Salinas‐Jazmín, Martín González‐Andrade, Marco A. Velasco‐Velázquez   +8 more
wiley   +1 more source