Results 11 to 20 of about 12,612 (175)

Heteropolyacides as green and reusable catalysts for the synthesis of [3,4-b][1,3,4] thiadiazines [PDF]

Bulletin of the Chemical Society of Ethiopia, 2014
Synthesis of [3,4-b][1,3,4]thiadiazines from the condensation of 4-amino-6-methyl-3-thioxo-1,2,4-triazine-5(2H)-one (AMTTO) or 4-amino-1,4-dihydro-5-methyle-1,2,4-triazole-5-thione (AMTT) with phenacyl bromide in the presence of a catalytic amount of ...
F. Hakimi, A. Hassanabadi, M. Tabatabaee, M. M. Heravi   +3 more
doaj   +2 more sources

Studies of in vitro anti-prostate cancer potential of newer 1,2,4-triazolo-1,3,4-thiadiazines with different heteroaromatics

Bangladesh Journal of Pharmacology, 2015
This study was aimed to evaluate anticancer potential of newer synthesize 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines and its derivatives. All newly furnished scaffolds were subjected to screening for their in vitro anticancer potential against DU-145 and ...
Mao-Chuan Fan, Guang-Ye Han, Xin-Jun Zhang, Hui-Fang Xi   +3 more
doaj   +2 more sources

Synthesis of New [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines and Study of Their Anti-Candidal and Cytotoxic Activities

Journal of Chemistry, 2014
New triazolothiadiazine derivatives 5a–h were synthesized from 4-amino-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazole (3) with substituted aryl hydrazonoyl chlorides 4a–h.
Mashooq Ahmad Bhat, Abdul Arif Khan, Shahanavaj Khan, Abdullah Al-Dhfyan   +3 more
doaj   +2 more sources

Synthesis of novel Bis-1,2,4-Triazolo[3,4-b][1,3,4]Thiadiazines from natural camphoric acid as potential anti-candidal agents

Results in Chemistry
Candida species have long been attributed to various diseases like candidiasis and systemic diseases and exacerbate the symptoms of immunocompromised patients.
Salama A. Ouf, Sobhi M. Gomha, Basant Farag, Magdi E.A. Zaki, Mohamed M. Ewies, Ihab A.A. Sharawy, Fatma O. Khalil, Huda K. Mahmoud   +7 more
doaj   +2 more sources

Efficient synthesis of novel azo compounds based on pyrimido[4,5-e][1,3,4]thiadiazine [PDF]

Bulletin of the Chemical Society of Ethiopia, 2012
Some new 5-bromo-2,4-dichloro-6-alkylpyrimidines were prepared by sequential treatment of 6-alkyl-pyrimidin-2,4(1H,3H)-diones with bromine and phosphoryl chloride.
Mohsen Nikpour, Soroush Zarinabadi, Sattar Saberi   +2 more
doaj   +2 more sources

Optimal strategy of new 6H-1,3,4-thiadiazines synthesis in search of the promising antidiabetic agents [PDF]

Chimica Techno Acta
In this work, we report a convenient method for the preparation of new 2-hydroxyethylamino-substituted 6Н-1,3,4-thiadiazine hydrobromides for the search of new agents with pleiotropic (antioxidant and antiglycating) activity.
Tatiana A. Tseitler, Larisa P. Sidorova, Alla V. Ivanova, Oleg N. Chupakhin   +3 more
doaj   +3 more sources

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis. [PDF]

ChemistryOpen
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
de Oliveira Borges JA, Freitas PR, Araújo IM, de Almeida RS, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, Kowalski R, Kowalska G, Coutinho HDM, Tintino SR, de Araújo ACJ.   +15 more
europepmc   +2 more sources

Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents. [PDF]

ISRN Org Chem, 2012
A series of novel 4‐amino‐5‐mercapto‐3‐[(3‐aralkyl amido/imidoalkyl) phenyl]‐1,2,4‐triazoles (5a-d) were obtained by treating m‐(aralkyl amido/imidoalkyl) benzoic acid hydrazides (3a-d) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively.
Pandey VK, Tusi Z, Tusi S, Joshi M.
europepmc   +2 more sources

SYNTHETIC STUDIES IN THE 6H-[1,2,4] TRIAZINO [3,4-b] [ 1,3,4] THIADIAZINES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1996
4-Amino-6-methyl- 1,2,4-triazine-3(2H)-thione-5-0ne (1) was condensed with propargyl bromidein the presence of sodium rnethoxide to afford 3-propargylmercapto- 4-arnino-6-rnethyl-1,2,4-triazin-5-one(2) .
doaj   +1 more source

Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors. [PDF]

Sci Rep, 2017
A novel series of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were designed, synthesized and biologically evaluated as vinylogous CA-4 analogues, which involved a rigid [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine scaffold to fix the ...
Xu Q, Bao K, Sun M, Xu J, Wang Y, Tian H, Zuo D, Guan Q, Wu Y, Zhang W.   +9 more
europepmc   +2 more sources