Results 31 to 40 of about 12,612 (175)

SYNTHESIS, CHARACTERIZATION AND BILOGICAL SCREENING OF SOME NOVEL INDOLE BASED 1,2,4-TRIAZOLO 1,3,4-THIADIAZINES [PDF]

, 2014
A series of novel 3-(1H-indole-4-yl)-6-aryl-7H-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazines (6a-f) were synthesized by involving 1H-indole-4-carboxylic acid (1) as raw material and 1H-indole-4-carboxylic acid ethyl ester (2), 1H-indole-4-carboxylic acid ...
Yata, Mahipal Reddy, Mekala, Raghu Vardhan Reddy, Talagadadivi, Ravi Prasad   +2 more
core   +1 more source

Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4‐disubstituted‐4H‐[1,3,4]‐thiadiazine‐5‐ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients. High incidence of antibiotic resistance in this pathogen makes the existent therapy inefficient. Type three secretion system (T3SS) is a leading virulence system of P.
Anna B. Sheremet, Naylia A. Zigangirova, Egor S. Zayakin, Sergei I. Luyksaar, Lydia N. Kapotina, Ludmila N. Nesterenko, Natalie V. Kobets, Alexander L. Gintsburg, Mariagrazia Di Luca   +8 more
wiley   +1 more source

Substituted 2-amino-1,3,4-thiadiazines: a novel solid-phase approach

, 2002
A novel and facile strategy for synthesis of substituted 2-amino-1,3,4-thiadiazines on solid support is described. Resin bound isothiocyanate prepared from an immobilised primary amine and di-(2-pyridyl)thionocarbonate was reacted with hydrazine hydrate ...
Jones, Raymond C. F., Kilburn, John Paul, Lau, Jesper   +2 more
core   +1 more source

Photochemical Ring Editing: Access to Privileged 1,2,5-Thiadiazole Scaffolds via Efficient Carbon Excision from Thiadiazines Under Ambient, Aerobic Conditions [PDF]

, 2022
Thiadiazoles are a privileged motif in medicinal chemistry, however selective mono-oxidation of the endocyclic sulfur, without over oxidation, is challenging.
Panayiotis A., Koutentis, Brendan, Gallagher, Georgina M., Rosair, Andreas S., Kalogirou, Christopher G., Thomson, Stuart A., Macgregor, Lia, Sotorríos, Gareth O., Lloyd, Kenneth G., McKendrick, Filipe, Vilela, Emmanouil, Broumidis, Janet E., Lovett, Martin J., Paterson   +12 more
core   +2 more sources

Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N‐Diethyl‐Substituted Amido Moieties

International Journal of Medicinal Chemistry, Volume 2012, Issue 1, 2012., 2012
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities. We have synthesized a series of α‐tolylsulfonamide, 1–11 and their substituted N,N‐diethyl‐2‐(phenylmethylsulfonamido) alkanamide derivatives, 12–22 in improved and excellent yields in aqueous medium at room ...
Olayinka O. Ajani, Oluwole B. Familoni, Feipeng Wu, Johnbull O. Echeme, Zheng Sujiang, Patrick Bednarski   +5 more
wiley   +1 more source

Synthesis and Characterization of Mono‐ and Bicycle Heterocyclic Derivatives Containing 1, 2,4‐Triazole, 1,3,4‐Thiadiazine and 1,3‐Thiazole Rings

Journal of Chemistry, Volume 9, Issue 1, Page 161-166, 2012., 2012
Reaction of tartaric acid with thiocarbohydrazide (2) and thiosemicarbazide (6) afforded 1,2‐bis(4‐amino‐5‐mercapto‐4H‐1,2,4‐triazol‐3‐yl)‐ethane‐1,2‐diol (3) and 1,2‐bis(5‐mercapto‐4H‐1,2,4‐triazol‐3‐yl)‐ethane‐1,2‐diol (7). Reaction of compounds 3 and 7 with DMAD (dimethylacety lendi carboxylate) and DEAD (diethylacetylendicarboxylate) gave 1,2‐bis(7‐
Navabeh Nami, Mehdi Forozani, Vida Khosravimoghadam, Rahmatallah Taherinasab   +3 more
wiley   +1 more source

Synthesis and Biological Activity of Some Novel 4‐(5‐Mercapto‐1,3,4‐thiadiazol‐2‐yl)‐2‐phenyl‐5‐[2‐phenylvinyl]‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐one

Journal of Chemistry, Volume 7, Issue 2, Page 545-550, 2010., 2010
A novel and efficient route have been designed for the synthesis of 4‐(5‐mercapto‐1,3,4‐thiadiazol‐2‐yl)‐2‐phenyl‐5‐[2‐phenylvinyl]‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐one. All the synthesized compound were characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectra.
Kumar Sanjeev S. Lamani, Oblennavar Kortesh   +1 more
wiley   +1 more source

Review of Imidazole Derivatives as Aromatase Inhibitors

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Breast cancer (BC) is the most commonly diagnosed malignancy in women globally, accounting for over 11% of all new cancer cases in female patients. Hormone receptor–positive BC relies on estrogen‐driven growth, making endocrine therapy a cornerstone of treatment. The standard clinical approach typically involves tamoxifen, a selective estrogen receptor
Haitham Al-Madhagi
wiley   +1 more source

Studies on Heterocyclic compounds of Medicinal Interest [PDF]

, 2011
Not ...
Ghetiya, Renish M.
core  

Studies on Chemical Entities of Therapeutic Interest [PDF]

, 2011
Not ...
Dodiya, Bhavesh L.
core