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Kristallin‐flüssige 1,3,4‐Thiadiazole. II [1]. 1,3,4‐Thiadiazole mit Cyclohexanstrukturfragmenten
Journal für Praktische Chemie, 1989Liquid Crystalline 1,3,4‐Thiadiazoles. II. 1,3,4‐Thiadiazoles with CyclohexanefragmentsPreparation and liquid crystalline properties of disubstituted 1,3,4‐thiadiazoles (1 and 2) are described. The mesomorphic behaviour of the title compounds is compared with their benzoate analogues. The dielectric anisotropy of these compounds is negative.
W. Schäfer +4 more
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Copper(II) complexes of 2-amino-1,3,4-thiadiazole and 2-ethylamino-1,3,4-thiadiazole
Transition Metal Chemistry, 1982Some copper(II) complexes of 2-amino-1,3,4-thiadiazole (atz) and 2-ethylamino-1,3,4-thiadiazole (eatz) have been prepared and studied by electronic, i.r. and e.p.r. spectra and by magnetochemical and conductometric methods. The CuX2 · atz (X=Cl, Br) and CuCl2 · eatz complexes are presumably six-coordinate with bridging ligand molecules and ...
Antonio C. Fabretti +2 more
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1,3,4-Thiadiazole: A Versatile Pharmacophore of Medicinal Significance
Medicinal Chemistry, 2023Abstract: The 1,3,4-thiadiazole nucleus has attracted the attention of medicinal chemists during the last decades due to its multiple pharmacological activities, such as antiviral, anticancer, antibacterial, and anticonvulsant activity. This scaffold's structural alteration could aid in developing novel therapeutically effective drugs.
Madhu, Bala +4 more
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1,3,4-THIADIAZOLES FROM THIOSEMICARBAZIDES
Phosphorus, Sulfur, and Silicon and the Related Elements, 1991Abstract A new method for the synthesis of 1,3,4-thiadiazoles is described. Thus condensation of 4-methyl-4phenyl-3-thiosemicarbazide with an aldehyde or ketone affords 1,1-disubstituted-6-[1-(arylethylidine) amino] −2,5-dithiobiureas, rather than the anticipated 4,4-disubstituted-3-thiosemicarbazones.
John P. Scovill +3 more
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Syntheses of arylsulfonyl‐1,3,4‐thiadiazoles
Journal of Heterocyclic Chemistry, 1996AbstractReaction of sodium arylsulfinate with 2‐aryl‐5‐chloro‐1,3,4‐thiadiazole gave 2‐aryl‐5‐arylsulfonyl‐1,3,4‐thiadiazole (3) in good yield. Starting from readily available 2‐amino‐5‐benzylmercapto‐1,3,4‐thiadiazole compound 7 was obtained in three steps in moderate yield.
A. Shafiee, A. Foroumadi
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1,3,4-Thiadiazole Based Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry, 2016In recent years, researchers like medicinal chemists in the field of medicinal chemistry have widely utilized the 1,3,4-thiadiazole nucleus to investigate its biological and pharmacological effects. This heterocyclic structure has demonstrated various bioactivities such as antifungal, antimicrobial, antiviral, antileishmanial, anti-inflammatory ...
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2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole
Acta Crystallographica Section C Crystal Structure Communications, 2001The structures of 2-amino-5-methyl-1,3,4-thiadiazole, C(3)H(5)N(3)S, and 2-amino-5-ethyl-1,3,4-thiadiazole, C(4)H(7)N(3)S, have been determined for comparison with unsubstituted 2-amino-1,3,4-thiadiazole. Despite their different space groups (P2(1)/n and Pbca, respectively), the packing modes of the methyl and ethyl derivatives are similar, with ...
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Synthesis of 1,3,4‐Thiadiazoles from Aldehyde Hydrazones.
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Kentaro Okuma +4 more
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New Cyclizing Reagent for the Synthesis of 1,3,4-Thiadiazoles
Synthesis, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Vladimir N. Yarovenko +5 more
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