Results 81 to 90 of about 15,802 (202)

Biological activity of heterocyclic systems based on functionally substituted 1,3,4-thia(oxa)diazoles (a review)

open access: yesФармацевтичний журнал, 2019
1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
doaj   +1 more source

2-(4-Fluoro-3-nitrophenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]-1,3,4-thiadiazole [PDF]

open access: yes, 2012
The title compound, 2-(4-fluoro-3-nitrophenyl)-6-(4-methoxyphenyl)­imidazo[2,1-b]-1,3,4-thiadiazole (3) was obtained by the condensation of 5-(4-fluoro-3-nitrophenyl)-[1,3,4]thiadiazol-2-ylamine (1) with 4-methoxyphenacyl bromide (2).
Balladka Kunhanna Sarojini   +2 more
core   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

open access: yesBiotechnology and Applied Biochemistry, Volume 73, Issue 1, Page 43-55, February 2026.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Synthesis, Characterization and Biological activity of 1,3,4- Oxadiazole and 1,3,4- Thiadiazole Derivatives. [PDF]

open access: yes, 2012
Various substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives have been synthesized by cyclising semicarbazone and thiosemicarbazone in presence of ferric chloride and citric acid to form 2-amino-5-substituted 1,3,4-oxadiazole and 1,3,4 ...
Smylin Ajitha Rani, S
core  

A Highly Efficient Diversification of 2‑Amino/Amido-1,3,4-oxadiazole and 1,3,4-Thiadiazole Derivatives via Reagent-Based Cyclization of Thiosemicarbazide Intermediate on Solid-Phase [PDF]

open access: yes, 2015
A 2-amino/amido-1,3,4-oxadiazole and 1,3,4-thiadiazole library has been constructed on solid-phase organic synthesis. The key step on this solid-phase synthesis involves the preparation of polymer-bound 2-amino-1,3,4-oxadiazole and 1,3,4-thiadiazole core
Ji-Hye Choe (1463143)   +3 more
core   +1 more source

Freezing Out Vavilov's Rule: Temperature‐Dependent Fluorescence of a Rhodanine Dye

open access: yesChemPhotoChem, Volume 10, Issue 2, February 2026.
Anomalous fluorescence behavior of a rhodanine‐based dye is revealed: weak emission at room temperature becomes intense at 77 K. The fluorescence quantum yield strongly depends on excitation wavelength, breaking Vavilov's rule. Quantum chemical studies show a delicate interplay between bright ππ* and dark nπ* states that governs this behavior.
Ottavia Racchi   +8 more
wiley   +1 more source

Toward the 3rd Generation of Smart Farming: Materials, Devices, and Systems for E‐Plant Technologies

open access: yesAdvanced Functional Materials, Volume 36, Issue 3, 8 January 2026.
This review explores the latest developments in e‐plant technologies, which are revolutionizing smart farming by enabling real‐time monitoring of plant and environmental conditions. It covers the design, applications, and systems of e‐plant devices, detailing how they integrate data analytics to optimize agricultural practices, enhance crop yields, and
Daegun Kim   +5 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors

open access: yesFrontiers in Chemistry, 2019
Twenty new 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition in vitro was evaluated in mouse peritoneal macrophages, HEK-293 cells transfected with hP2X7R (dye uptake assay), and ...
Daniel T. G. Gonzaga   +16 more
doaj   +1 more source

6-(4-Chlorophenyl)-2-isobutylimidazo[2,1-b][1,3,4]thiadiazole [PDF]

open access: yes, 2010
In the title compound, C14H14ClN3S, the imidazo[2,1-b][1,3,4]thiadiazole system is essentially planar, with a maximum deviation of 0.006 (2) Å.
D. Jagadeesh Prasad   +4 more
core   +1 more source

Polar Switching and Cybotactic Nematic Ordering in 1,3,4-Thiadiazole-Based Short-Core Hockey Stick-Shaped Fluorescent Liquid Crystals [PDF]

open access: yes, 2019
We report here the synthesis and thermotropic properties of novel short-core hockey stick-shaped liquid crystalline molecules based on the 1,3,4-thiadiazole core.
Santosh Prasad Gupta (3387977)   +13 more
core   +1 more source

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