Results 71 to 80 of about 8,138 (214)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Synthesis, Characterisation And Cytotoxicity Study Of Some New 1,2,4-Triazole Derivatives [PDF]

, 2017
Dalam kajian ini, 36 sebatian baru 1,2,4-triazol dengan sistem gelang mono dan terlakur telah disintesis dan dicirikan In this study, 36 new 1,2,4-triazole compounds with mono and fused ring system have been synthesised and ...
Mohsin Slaihim, Mukhlif
core  

Synthesis and Evaluation of Antimicrobial Activity of Tetranorlabdane Compounds Bearing 1,3,4-Thiadiazole Units

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2023
Synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment has been reported. The structures of the new synthesized compounds were confirmed using IR and 1H, 13C,
Svetlana Blaja, Lidia Lungu, Alexandru Ciocarlan, Nicoleta Vornicu, Aculina Aricu   +4 more
doaj   +1 more source

Toward Nanostructured Conducting Polymers: Synthesis, Synergies, Applications, and Sustainability

International Journal of Polymer Science, Volume 2026, Issue 1, 2026.
Nanostructured conducting polymers (CPs) have emerged as promising materials due to their facile synthesis and remarkable mechanical, optical, and electrochemical properties, alongside superior environmental stability. This review provides an in‐depth analysis of prominent CPs, including polyaniline, polycarbazole, polypyrrole, polythiophene, and poly ...
Ayesha Murtaza, Tauseef-ur Rehman, Navid Aslfattahi, Gyu Man Kim, Cheol Woo Park, Hamouda M. Mousa   +5 more
wiley   +1 more source

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazole derivatives and their in vivo anticonvulsant activity [PDF]

, 2014
A series of 2,5-disubstituted-1,3,4-thiadiazole derivatives were synthesized by the reaction of 3-(2-cyanopropan-2-yl)-N-(5-(piperazine-1-yl)-1, 3,4-thiadiazol-2-yl)benzamide with various sulfonyl chlorides and evaluated for their anticonvulsant activity
Harish, K. P., Mohana, K. N., Mallesha, L.   +2 more
core   +3 more sources

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Novel highly emissive non proteinogenic amino acids : synthesis of 1,3,4-thiadiazolyl asparagines and evaluation as fluorimetric chemosensors for biologically relevant transition metal cations [PDF]

, 2011
Highly emissive heterocyclic asparagine derivatives bearing a 1,3,4-thiadiazolyl unit at the side chain, functionalised with electron donor or acceptor groups, were synthesised and evaluated as amino acid based fluorimetric chemosensors for metal cations
A García-Raso, A Torrado, AT Wright, BP Joshi, CIC Esteves, CP Mandl, Cátia I. C. Esteves, DRW Hodgson, F Qu, FM Pfeffer, G Heinrichs, H Ishida, H Kozlowski, H Li, HA Azab, HJ Schneider, J Lin, J Zhao, JJ Gooding, JM Mathews, JV Morris, L-J Fan, M Abo-Ghalia, M Togrul, M. Manuela M. Raposo, MG Holler, MR Heinrich, N Voyer, OA Fedorova, P Kumar, R Martínez-Manêz, RMF Batista, RMF Batista, RMF Batista, RP Cheng, SPG Costa, SPG Costa, SPG Costa, SPG Costa, Susana P. G. Costa, VK Gupta, W Yang, Y Shimazaki, Y Zheng, Z Xu   +44 more
core   +1 more source

Biological activity of heterocyclic systems based on functionally substituted 1,3,4-thia(oxa)diazoles (a review)

Фармацевтичний журнал, 2019
1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
doaj   +1 more source

Synthesis and Study of Some 4-Chlorophenoxy Methyl Substituted amido1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro phenoxy acetic acid [PDF]

مجلة التربية والعلم, 2013
: In this paper the synthesis of some substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. 4-Chlorophenol was treated with chloroacetic acid to give 4-chlorophenoxy acetic acid (C1) which was reacted with thionyl chloride ...
Mudhar A. Othman, Khalid M. Daoud
doaj   +1 more source

Recent developments in the chemistry and enzyme inhibitory activity of fused thiazoles and thiadiazoles

Vietnam Journal of Chemistry, Volume 63, Issue 6, Page 872-882, December 2025.
Abstract The combination of cyclization reactions of thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling reactions provided a convenient synthesis of annulated, fluorinated and non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐ones, benzothiazolo[3,2‐a]pyridimidin‐4‐ones, benzothiazolo[2,3‐b]quinazolin‐12‐ones and ...
Peter Langer
wiley   +1 more source