Results 71 to 80 of about 18,261 (204)
International Journal of Electrochemical Science, 2011 Three new thiadiazole derivatives (TDADs), namely, (I) N-[4-phenyl-5-(p-tolylimino)-4,5-dihydro-1,3,4-thiadiazole-2-yl] benzamide, (II) 2-acetyl-4-phenyl-5-(p-tolylimino)-4,5-dihydro-1,3,4-thiadiazole, and (III) Ethyl-4-phenyl-5-(p-tolylimino)-4,5 ...
F. El-Taib Heakal +2 more
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 8, August 2026.This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan +2 more
wiley +1 more source
Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole
In this study, 24 indole derivatives containing 1,3,4-thiadiazole were discovered and synthesized. The target compounds’ antifungal efficacy against 14 plant pathogenic fungal pathogens was then determined in vitro.
Bangcan He (18452570) +8 more
core +1 more source
An Efficient and Convenient Protocol for the Synthesis of Optically Active 1,2,4-Triazolo-[3,4-b]-[1,3,4]-Thiadiazole, 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives having L-Amino Acid Moieties [PDF]
, 2015 A series of novel bis triazolothiadiazole, 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives attached to L-amino acid moieties were synthesized in good yields using a simple and practical method.
Mobinikhaldei, A +3 more
core
Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides
Molecules, 2010 Starting from 4-chlorobenzoic acid, 10 new 5-(4-chlorophenyl)-N-substituted-N-1,3,4-thiadiazole-2-sulfonamide derivatives were synthesized in six-steps. Esterification of 4-chlorobenzoic acid with methanol and subsequent hydrazination, salt formation and
Yuping Zhang +7 more
doaj +1 more source
3-Benzhydryl-1,3,4-thiadiazole-2(3H)-thione [PDF]
, 2013 In the title compound, C15H12N2S2, the two phenyl rings and the planar (r.m.s. deviation = 0.002 Å) thiadiazole ring adopt a propeller conformation about the central C—H axis with H—C—C—C(phenyl) torsion angles of 44 ...
T. Thornton, Megan +10 more
core +2 more sources
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 New chalcones of -{ - - - y - - hi di z e- -y he y - - e e- - e- - - substituted phenyl have been prepared from condensation of a new of 4-[5-(4`-tolyl)1,3,4-thiadiazole-2-yl] benzaldehyde (which is synthesized by the ...
Jumbad H. Tomma. +2 more
doaj +1 more source
Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, Volume 47, Issue 7, Page 855-869, July 2026.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
Chemoselective one-pot synthesis of 2-phenylamino-5-alkylthio-1,3,4-thiadiazole derivatives from phenylthiosemicarbazide and CS2 [PDF]
, 2014 A novel and fairly efficient chemoselective one-pot method has been developed for the synthesis of both 2-phenylamino-5-alkylthio-1,3,4-thiadiazole and bis-(2-phenylamino-5-alkylthio-)1,3,4-thiadiazole derivatives from phenylthiosemicarbazide and ...
Kohzadi, Homa +2 more
core +1 more source
Фармацевтичний журнал, 2019 1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
doaj +1 more source