Results 51 to 60 of about 15,802 (202)

N-(5-Benzylsulfanyl-1,3,4-thiadiazol-2-yl)-2-(piperidin-1-yl)acetamide

Acta Crystallographica Section E, 2014
The title compound, C16H20N4OS2, was synthesized by the reaction of 2-benzylsulfanyl-5-chloroacetamido-1,3,4-thiadiazole and piperidine in a 1:2 ratio. The planes of the acetamide and 1,3,4-thiadiazole units are twisted by 10.8 (4)°.
D. S. Ismailova, R. Ya. Okmanov, A. A. Ziyaev, Kh. M. Shakhidoyatov, B. Tashkhodjaev   +4 more
doaj   +1 more source

Solvent Induced Disulfide Bond Formation in 2,5-dimercapto-1,3,4-thiadiazole [PDF]

, 2007
Disulfide bond formation is the decisive event in the protein folding to determine the conformation and stability of protein. To achieve this disulfide bond formation in vitro, we took 2,5-dimercapto-1,3,4-thiadiazole (DMcT) as a model compound. We found
Palraj Kalimuthu, S. Abraham John, Palanisamy Kalimuthu   +2 more
core   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Aquabis[2,5-bis(pyridin-2-yl)-1,3,4-thiadiazole-κ2N2,N3](trifluoromethanesulfonato-κO)copper(II) trifluoromethanesulfonate

Acta Crystallographica Section E, 2012
2,5-Bis(pyridin-2-yl)-1,3,4-thiadiazole (denoted L) has been found to act as a bidentate ligand in the monomeric title complex, [Cu(CF3O3S)(C12H8N4S)2(H2O)](CF3O3S). The complex shows a distorted octahedrally coordinated copper(II) cation which is linked
Fouad Bentiss, Moha Outirite, Michel Lagrenée, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

3-Benzhydryl-1,3,4-thiadiazole-2(3H)-thione [PDF]

, 2013
In the title compound, C15H12N2S2, the two phenyl rings and the planar (r.m.s. deviation = 0.002 Å) thiadiazole ring adopt a propeller conformation about the central C—H axis with H—C—C—C(phenyl) torsion angles of 44 ...
T. Thornton, Megan, Healy, Peter, Thornton, MT, Healy, PC, C. Henderson, Luke, Henderson, Luke, Peter C. Healy, Luke C. Henderson, Thornton, Megan, Megan T. Thornton, Henderson, LC   +10 more
core   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Designed Lewis Acid–Base Passivation for High Performance Perovskite Solar Cells

Advanced Functional Materials, Volume 36, Issue 51, 25 June 2026.
ABSTRACT Silicon's high cost and long energy payback time remain major barriers to the global expansion of solar power. In contrast, metal–halide perovskites offer abundant, solution‐processable absorbers, and have achieved efficiencies of 25%–30%, positioning them as strong competitors to silicon.
Afna Manaf, Hiba Shahulhameed, Bhabani Sankar Swain, Shengzhong (Frank) Liu, Adel Najar   +4 more
wiley   +1 more source

Synthesis and Evaluation of 5-Benzyl-1,3,4-Thiadiazole Derivatives as Acetylcholinesterase Inhibitors [PDF]

, 2017
Three novel 5-benzyl-1,3,4-thiadiazole derivatives were synthesised starting from phenylacetic acid derivatives. These compounds were characterised by NMR, HRMS and single-crystal X-ray diffraction analysis.
Yu-Wei Liu, Chen Lu, Xiao-Dong Ma, Meng-Qiu Song, Hui-Long Zhu, Zong-Ming Tang, Wei-Wei Liu, Xiao-Kai Song, Da-Hua Shi, Tong Dong   +9 more
core   +1 more source

Crystal structures of three 6-aryl-2-(4-chlorobenzyl)-5-[(1H-indol-3-yl)methyl]imidazo[2,1-b][1,3,4]thiadiazoles

Acta Crystallographica Section E: Crystallographic Communications, 2020
Three title compounds, namely, 2-(4-chlorobenzyl)-5-[(1H-indol-3-yl)methyl]-6-phenylimidazo[2,1-b][1,3,4]thiadiazole, C26H19ClN4S, (I), 2-(4-chlorobenzyl)-6-(4-fluorophenyl)-5-[(1H-indol-3-yl)methyl]imidazo[2,1-b][1,3,4]thiadiazole, C26H18ClFN4S, (II ...
Sadashivamurthy Shamanth, Kempegowda Mantelingu, Haruvegowda Kiran Kumar, Hemmige S. Yathirajan, Sabine Foro, Christopher Glidewell   +5 more
doaj   +1 more source