Results 31 to 40 of about 360 (144)

Synthesis and preliminary bioassays of some bis -1,3 - benzoxazines

Revista Colombiana de Química, 2010
Se hicieron ensayos preliminares con miras a establecer la posible actividad insecticida de cinco bis-l,3-benzoxazinas del tipo 3,3-etilen-bis(3,4-dihidro-6R-2H-1,3-benzoxazina).
A. Rivera, J. Calle, M. Zamudio, F. Aristizabal, P. Joseph-Nathan   +4 more
doaj  

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 14, Issue 6, Page 461-471, June 2025.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

REARRANGEMENT OF SUBSTITUTED 1,3-BENZOXAZINES INTO XANTHENE-TYPE COMPOUNDS

Ukrainian Chemistry Journal, 2020
The rearrangement patterns of new 1,3-benzoxazines derivatives obtained by condensation of substituted salicylamides with cyclic ketones under the influence of Vilsmeier-Haack reagent has been studied. The influence of angel strain in a 4-membered spirocycle prevents the rearrangement of spiro [1,3-benzoxazine-2,1'-cyclobutan]-4(3H)-one under the ...
Oleg Farat, Svetlana Varenichenko, Ekaterina Zaliznaya, Victor Markov   +3 more
openaire   +2 more sources

Activation and inhibition of sirtuins: From bench to bedside

Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.
Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino, Emanuele Fabbrizi, Antonello Mai, Dante Rotili   +3 more
wiley   +1 more source

A Systematic Study on the Polymerization Processes and Resulting Polymer Properties of Bioinspired Sesamol and Diamine‐Based Benzoxazines

Journal of Applied Polymer Science, Volume 142, Issue 7, February 15, 2025.
Benzoxazine monomers based on sesamol, paraformaldehyde, and diamines feature a parity effect of used aliphatic diamine with a decrease in melting temperature in case of odd‐numbered diamines. Diaminopentane and ‐hexane yielded polybenzoxazines with good thermal and thermo‐mechanical properties.
Thorben S. Haubold, Gideon Abels, Katharina Koschek   +2 more
wiley   +1 more source

Enantioselective Cascade Reactions of Aminocatalytic Dienamines and Trienamines Initiated by a Cycloaddition Reaction

Chemistry – A European Journal, Volume 31, Issue 1, January 2, 2025.
This review outlines and showcases how aminocatalytic dienamines and trienamines can be used in stereoselective cascade reactions, that are initiated by a cycloaddition reaction to rapidly access complex chiral molecules. We aspire that the chemical community can use this review to design new cascade reaction or use current methodologies in complex ...
Jonas Faghtmann, Signe Sofie Pladsbjerg Andresen, Anne Rask Østergaard, Karl Anker Jørgensen   +3 more
wiley   +1 more source

Rhodium‐Catalyzed C−H Bond Annulation for the Synthesis of 5‐ and 6‐Membered N‐Heterocyclic Building Blocks

ChemCatChem, Volume 16, Issue 24, December 20, 2024.
This review examines rhodium‐catalyzed C−H bond annulations for synthesizing 5‐ and 6‐membered nitrogen‐containing heterocycles, focusing on the underlying mechanisms and catalyst regeneration strategies. These include external oxidant, oxidazing directing group, redox‐neutral, and electrochemical methods, highlighting advances in heterocyclic ...
Marie Peng, Henri Doucet, Jean‐François Soulé   +2 more
wiley   +1 more source

Dynamic Covalent Chemistry of Enamine‐Ones: Exploring Tunable Reactivity in Vitrimeric Polymers and Covalent Organic Frameworks

ChemSusChem, Volume 17, Issue 22, November 25, 2024.
This review summarizes the dynamic covalent chemistry of enamine‐ones, focusing on factors affecting the tunable exchange kinetics and its exploitation in the development of recyclable, reprocessable and self‐healable vitrimers. Enamine‐one integrated commodity polymers such as siloxanes, epoxies, acrylates, polyethylene glycols (PEGs), fluoropolymers ...
Thaksen Jadhav, Bhausaheb Dhokale, Zeinab M. Saeed, Nikos Hadjichristidis, Sharmarke Mohamed   +4 more
wiley   +1 more source

Ferrocenyl Aminocresols Display Multimodal Activity Against Triple‐Negative Breast Cancer Cells In Vitro

ChemistrySelect, Volume 9, Issue 42, November 8, 2024.
Cresol‐based ferrocenyl benzoxazines display multimodal activity against triple‐negative breast cancer cells in vitro, which includes binding to DNA through intercalation and minor groove binding, causing significant DNA damage, as well as inducing DNA DSBs.
Richwell Mhlanga, Mziyanda Mbaba, Ronald Tonui, Adrienne L. Edkins, Setshaba D. Khanye, Jo‐Anne de la Mare   +5 more
wiley   +1 more source

Practical One-Pot Multistep Synthesis of 2H-1,3-Benzoxazines Using Copper, Hydrogen Peroxide and Triethylamine. [PDF]

European J Org Chem, 2021
Trammell R, Cordova A, Zhang S, Goswami S, Murata R, Siegler MA, Garcia-Bosch I.   +6 more
europepmc   +1 more source