Results 51 to 60 of about 433,597 (216)

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 14, Issue 6, Page 461-471, June 2025.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

Multifunctional Benzoxazines Feature Low Polymerization Temperature and Diverse Polymer Structures

, 2016
3,4-dihydro-3-phenyl-2H-1,3-benzoxazines derived from phenol-, resorcinol-, and phloroglucinol give monomers with one, two, and three oxazine units at a single benzene ring, respectively.
Marc Soto, Matthias Hiller, Katharina Koschek, Hartmut Oschkinat   +3 more
core   +2 more sources

Novel polybenzoxazine-based arylidene moiety modified cellulose acetate for enhanced antifouling properties

Materials Research Express
Marine fouling is a widespread problem in the maritime industry, causing significant damage to equipment and vessels. Polybenzoxazine (PBz) is a resin that is both remarkable and captivating, and it has a wide range of sophisticated uses.
Hafsah Klfout, Abdullah M Asiri, Khalid A Alamry, Mahmoud A Hussein   +3 more
doaj   +1 more source

Activation and inhibition of sirtuins: From bench to bedside

Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.
Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino, Emanuele Fabbrizi, Antonello Mai, Dante Rotili   +3 more
wiley   +1 more source

Photochemical Polymerization of N‑Phenyl Mono-1,3-benzoxazines in Aqueous Media

, 2018
Some N-phenyl monosubstituted mono-1,3-benzoxazines can be polymerized under appropriate UV irradiation in aqueous solutions at room temperature. Photoinduced intramolecular electron transfer from the amine to the phenyl ring in aqueous media produces ...
Rosa María Sebastián (1795849), Jordi Salabert (5171951), Jordi Marquet (1795843)   +2 more
core   +1 more source

Synthesis and preliminary bioassays of some bis -1,3 - benzoxazines

Revista Colombiana de Química, 2010
Se hicieron ensayos preliminares con miras a establecer la posible actividad insecticida de cinco bis-l,3-benzoxazinas del tipo 3,3-etilen-bis(3,4-dihidro-6R-2H-1,3-benzoxazina).
A. Rivera, J. Calle, M. Zamudio, F. Aristizabal, P. Joseph-Nathan   +4 more
doaj  

A Systematic Study on the Polymerization Processes and Resulting Polymer Properties of Bioinspired Sesamol and Diamine‐Based Benzoxazines

Journal of Applied Polymer Science, Volume 142, Issue 7, February 15, 2025.
Benzoxazine monomers based on sesamol, paraformaldehyde, and diamines feature a parity effect of used aliphatic diamine with a decrease in melting temperature in case of odd‐numbered diamines. Diaminopentane and ‐hexane yielded polybenzoxazines with good thermal and thermo‐mechanical properties.
Thorben S. Haubold, Gideon Abels, Katharina Koschek   +2 more
wiley   +1 more source

Enantioselective Cascade Reactions of Aminocatalytic Dienamines and Trienamines Initiated by a Cycloaddition Reaction

Chemistry – A European Journal, Volume 31, Issue 1, January 2, 2025.
This review outlines and showcases how aminocatalytic dienamines and trienamines can be used in stereoselective cascade reactions, that are initiated by a cycloaddition reaction to rapidly access complex chiral molecules. We aspire that the chemical community can use this review to design new cascade reaction or use current methodologies in complex ...
Jonas Faghtmann, Signe Sofie Pladsbjerg Andresen, Anne Rask Østergaard, Karl Anker Jørgensen   +3 more
wiley   +1 more source

‐[1,4]benzoxazines [PDF]

, 2020
Stereoselectivity in the mutual kinetic resolution (KR) of racemic 3,4-dihydro-3-methyl-2H-[1,4]benzoxazines and racemic 2-aryloxy propionyl chlorides was studied. Based on the results obtained, preparative methods for single enantiomers of a series of 2-
Ganebnykh, I. N., Ilya N. Ganebnykh, Liliya Sh. Sadretdinova, Mikhail I. Kodess, Vakarov, S. A., Levit, G. L., Pervova, M. G., Ezhikova, M. A., Chulakov, E. N., Sadretdinova, L. S., Marina A. Ezhikova, Krasnov, V. P., Kodess, M. I., Sergey A. Vakarov, Marina G. Pervova, Evgeny N. Chulakov, Victor P. Krasnov, Galina L. Levit   +17 more
core   +1 more source

Rhodium‐Catalyzed C−H Bond Annulation for the Synthesis of 5‐ and 6‐Membered N‐Heterocyclic Building Blocks

ChemCatChem, Volume 16, Issue 24, December 20, 2024.
This review examines rhodium‐catalyzed C−H bond annulations for synthesizing 5‐ and 6‐membered nitrogen‐containing heterocycles, focusing on the underlying mechanisms and catalyst regeneration strategies. These include external oxidant, oxidazing directing group, redox‐neutral, and electrochemical methods, highlighting advances in heterocyclic ...
Marie Peng, Henri Doucet, Jean‐François Soulé   +2 more
wiley   +1 more source