Results 51 to 60 of about 4,239 (193)

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Cristais líquidos termotrópicos calamíticos contendo o heterociclo [1,2,3]-triazol 1,4-dissubstituído [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em QuímicaA síntese e as propriedades térmicas de cinco séries homólogas de compostos calamíticos lineares e não lineares,
Santos, Deise Maria Pereira de Oliveira
core  

A Modular Synthesis of Isoindole/Indolizine Hybrids via the 1,3‐Dipolar Cycloaddition of Pyridine‐Based Mesoionics with Benzyne

European Journal of Organic Chemistry, EarlyView.
An approach to prepare pyrido[2,1‐a]isoindoles via the cycloaddition of pyridine‐based 1,3‐dipoles and benzyne is described, offering modular access to a range of substituted products by systematic tuning of the dipole. A modular strategy for the synthesis of fused indolizine/isoindole hybrids, pyrido[2,1‐α]isoindoles, via cycloaddition of pyridine ...
Samira Taghizadeh Nodehi, Mohammad Ghanbari, Bruce A. Arndtsen   +2 more
wiley   +1 more source

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

Molecules, 2023
Multicomponent reactions (MCRs) have undoubtedly emerged as the most indispensable tool for organic chemists worldwide, finding extensive utility in the synthesis of intricate natural products, heterocyclic molecules with significant bioactivity, and ...
Hua Zhao, Yufen Zhao
doaj   +1 more source

Intramolecular 1,3-Dipolar Cycloadditions of Norbornadiene-Tethered Nitrile Oxides

, 2016
Efficient routes to the synthesis of norbornadiene-tethered nitrile oxides have been developed, and their intramolecular 1,3-dipolar cycloadditions were studied.
Geoffrey K. Tranmer (2520547), Sean Handerson (3027795), William Tam (640256), Carol Yip (3027792)   +3 more
core   +1 more source

Synthesis of 2‐Aza‐Bicyclo[4.3.0]nonane Derivatives Related to the Camporidines via Intramolecular [3+2]‐Cycloaddition

European Journal of Organic Chemistry, EarlyView.
The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher, Tobias Wilczek, Nora Katharina Korber, Jörg-Martin Neudörfl, Bernd Goldfuss, Hans-Günther Schmalz   +5 more
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}

Beilstein Journal of Organic Chemistry, 2008
Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Subrata Mandal, Wen Tai Li, Yan Bai, Jon D. Robertus, Sean M. Kerwin   +4 more
doaj   +1 more source

High‐performance electro‐optic materials featuring enhanced thermal stability through dual‐donor structural crosslinking engineering

Smart Molecules, EarlyView.
A groundbreaking dual‐donor crosslinking strategy was reported to significantly enhance the thermal stability, achieving remarkable EO coefficients (257–301 pm/V), glass transition temperatures (Tg) ranging from 107–187°C, and ultrahigh chromophore densities (3.73–4.26 × 10²⁰ molecules/cm³) with exceptional long‐term stability after 500 h at 85°C ...
Yu Zhang, Ziyun Zheng, Zhihan Huang, Zhifan Liu, Youling Chen, Fuyang Huo, Fenggang Liu, Xiubin Xu   +7 more
wiley   +1 more source

Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles

Acta Pharmaceutica Sinica B, 2012
Regio- and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone (10) were carried out with different mono-substituted, disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-3 ...
Vishal Sharma, Raman Kalia, Tilak Raj, Vivek K. Gupta, Nitasha Suri, Ajit K. Saxena, Deepak Sharma, Surinderjit S. Bhella, Gurpinder Singh, Mohan Paul S. Ishar   +9 more
doaj   +1 more source