Results 51 to 60 of about 1,432 (170)

Reaction Enumeration Based on NBO‐Informed Molecular Graphs

Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.
NBO‐informed molecular graphs represent chemistry via valence orbitals rather than atomic connectivity, enabling consistent reaction analysis across environments. By identifying delocalized motifs and increasing complexity adaptively, the framework enables efficient exploration of inaccessible mechanisms and diverse catalytic and reaction networks for ...
Javier E. Alfonso‐Ramos, Thijs Stuyver
wiley   +1 more source

The Fragmentation of 2,3-Dihydroisothiazol-3-one 1,1-Dioxide Derivatives: A Novel Cheletropic Process

CHIMIA, 1992
Adducts obtained by 1,3-dipolar cycloadditions to 2,3-dihydroisothiazol-3-one 1,1-dioxides are inclined to undergo a cheletropic process, by which the newly formed heterocyclic part undergoes aromatization, while SO2 is extruded and an ...
Kaspar F. Burri
doaj   +2 more sources

Reactions of 1,2,4‐Oxadiazole[4,5‐a]piridinium Salts with Alcohols: the Synthesis of Alkoxybutadienyl 1,2,4‐Oxadiazoles

ChemistryOpen, 2020
1,2,4‐Oxadiazole[4,5‐a]piridinium salts add alcohols and alkoxides to undergo electrocyclic ring opening affording alkoxybutadienyl 1,2,4‐oxadiazole derivatives.
Dr. Mattia Moiola, Dr. Marco Leusciatti, Prof. Dr. Paolo Quadrelli   +2 more
doaj   +1 more source

5-Formyltriazoles as Valuable Starting Materials for Unsymmetrically Substituted Bi-1,2,3-Triazoles

Frontiers in Chemistry, 2020
Herein, we present the first synthetic methodologies toward non-symmetrical 5,5′-C, C-linked bi-1,2,3-triazoles starting from 5-formyl-1,2,3-triazole via two related pathways.
Robby Vroemans, Tomas Horsten, Maarten Van Espen, Wim Dehaen   +3 more
doaj   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

A Modular Synthesis of Isoindole/Indolizine Hybrids via the 1,3‐Dipolar Cycloaddition of Pyridine‐Based Mesoionics with Benzyne

European Journal of Organic Chemistry, Volume 29, Issue 26, 13 July 2026.
An approach to prepare pyrido[2,1‐a]isoindoles via the cycloaddition of pyridine‐based 1,3‐dipoles and benzyne is described, offering modular access to a range of substituted products by systematic tuning of the dipole. A modular strategy for the synthesis of fused indolizine/isoindole hybrids, pyrido[2,1‐α]isoindoles, via cycloaddition of pyridine ...
Samira Taghizadeh Nodehi, Mohammad Ghanbari, Bruce A. Arndtsen   +2 more
wiley   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, Volume 13, Issue 38, 9 July 2026.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Enantioselective 1,3-Dipolar Cycloadditions of α-Methylene Lactams to Construct Spirocycles. [PDF]

Org Lett, 2023
Nishiura Y, Gonzalez KJ, Cusumano AQ, Stoltz BM.   +3 more
europepmc   +1 more source

An Overlooked Pathway in 1,3-Dipolar Cycloadditions of Diazoalkanes with Enamines. [PDF]

Angew Chem Int Ed Engl, 2022
Li L, Mayer P, Stephenson DS, Ofial AR, Mayer RJ, Mayr H.   +5 more
europepmc   +1 more source