Results 41 to 50 of about 1,432 (170)

Think Beyond The Core: Computationally Decoding the Hydrophilic Corona of Drug‐Loaded Polymer Micelles

Small, EarlyView.
Drug‐loaded ABA‐type triblock copolymer micelles with a hydrophobic poly(2‐n‐butyl‐2‐oxazine) core (B‐block) and hydrophilic coronas (pEG, pDMAA, pSAR (A‐block)) are investigated by all‐atom molecular dynamics simulations at 20% and 60% curcumin loadings.
Maksym Karachevtsev, Josef Kehrein, Terttu Hukka, Alex Bunker, Mikko Karttunen, Robert Luxenhofer   +5 more
wiley   +1 more source

High‐performance electro‐optic materials featuring enhanced thermal stability through dual‐donor structural crosslinking engineering

Smart Molecules, EarlyView.
A groundbreaking dual‐donor crosslinking strategy was reported to significantly enhance the thermal stability, achieving remarkable EO coefficients (257–301 pm/V), glass transition temperatures (Tg) ranging from 107–187°C, and ultrahigh chromophore densities (3.73–4.26 × 10²⁰ molecules/cm³) with exceptional long‐term stability after 500 h at 85°C ...
Yu Zhang, Ziyun Zheng, Zhihan Huang, Zhifan Liu, Youling Chen, Fuyang Huo, Fenggang Liu, Xiubin Xu   +7 more
wiley   +1 more source

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}

Beilstein Journal of Organic Chemistry, 2008
Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Subrata Mandal, Wen Tai Li, Yan Bai, Jon D. Robertus, Sean M. Kerwin   +4 more
doaj   +1 more source

Synthesis and cytotoxic evaluation of substituted 3-(3′-indolyl-/3′-pyridyl)-isoxazolidines and bis-indoles

Acta Pharmaceutica Sinica B, 2012
Regio- and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone (10) were carried out with different mono-substituted, disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-3 ...
Vishal Sharma, Raman Kalia, Tilak Raj, Vivek K. Gupta, Nitasha Suri, Ajit K. Saxena, Deepak Sharma, Surinderjit S. Bhella, Gurpinder Singh, Mohan Paul S. Ishar   +9 more
doaj   +1 more source

Creating a Masterpiece. The Road to (and Beyond) Woodward and Hoffmann's 1969 Angewandte Chemie Treatise

The Chemical Record, EarlyView.
This publication describes how R. B. Woodward and Roald Hoffmann crafted their masterpiece publications. Illustrations include Woodward's first draft of the famous “Violations There are none. Nor can violations be expected of so fundamental a principle of maximum bonding.” Original but discarded text shows the stepwise paths toward the W‐H masterpieces.
Jeffrey I. Seeman
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

1,3-Dipolar Cycloadditions of N-Benzyl Furfuryl Nitrones with Electron-rich Alkenes

Molecules, 2000
The 1,3-dipolar cycloaddition reaction of N-benzyl-C-(2-furyl)nitrones with electron-rich alkenes gives preferentially trans-substituted 3,5-disubstituted isoxazolidines (endo approach).
Tomas Tejero, Francisco L. Merchan, Sonia Anoro, Pedro Merino   +3 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Nuclear Quantum Effects on the Organic Bifurcation Reaction in Microsolvated Water Clusters: Ring‐Polymer Molecular Dynamics Calculations Using an Explicit Solvation Model

Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.
Ring‐polymer molecular dynamics in explicit water clusters shows that nuclear quantum effects steer an organic bifurcation reaction—enhancing the minor (4 + 2) channel and accelerating water‐mediated proton transfer—proving that accurate aqueous reaction dynamics require both explicit solvation and nuclear quantum effects. ABSTRACT Solvent environments
Shoto Nakagawa, Hayato Matsubuchi, Haruki Ota, Toshiyuki Takayanagi, Tatsuhiro Murakami   +4 more
wiley   +1 more source

A novel application of 2-silylated 1,3-dithiolanes for the synthesis of aryl/hetaryl-substituted ethenes and dibenzofulvenes

Beilstein Journal of Organic Chemistry, 2017
Trimethylsilyldiazomethane (TMS-CHN2) reacts readily with hetaryl thioketones to give sterically crowded 2-trimethylsilyl-4,4,5,5-tetrahetaryl-1,3-dithiolanes with complete regioselectivity at −75 °C as well as at rt.
Grzegorz Mlostoń, Paulina Pipiak, Róża Hamera-Fałdyga, Heinz Heimgartner   +3 more
doaj   +1 more source