Results 161 to 170 of about 284,169 (292)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Verification of the specificity of the PGC-1α antibody.
, 2014 Representative images of PGC-1α (approx. 100 KDa) and β-tubulin (approx. 50 KDa - loading control) western blots performed in mouse gastrocniemius (M. Gas) rat soleus (R. SOL) and plantaris (R.
Brandon Norris (615730) +8 more
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Normal differentiation of the notochord in absence of HIF-1α.
, 2014 A. H&E staining of E13.5 spine in control (Foxa2iCre;HIF-1αf/+) (a) and mutant (Foxa2iCre;HIF-1αf/f) (b) mice. High magnification of E13.5 NP in control (Foxa2iCre;HIF-1αf/+) (c) and mutant (Foxa2iCre;HIF-1αf/f) (d) mice. Bar = 50 µm. B.
Amato J. Giaccia (545955) +7 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Experimental GerontologyBackground: Aged sarcopenia is characterized by loss of skeletal muscle mass and strength, and mitochondrial dysregulation in skeletal myocyte is considered as a major factor.
Lei Song +5 more
doaj +1 more source
Elevation of mRNA Expressions of PGC-1α-b and PGC-1α-c by 5HT.
, 2016 A, In 8 weeks of age mice, the mRNA expression levels of PGC-1α-b and PGC-1α-c were measured in soleus muscle and after i.p. injection of 1 mg 5-HT by real time PCR (n = 6–8). B, The relative mRNA expression levels of 5-HTR were measured in soleus muscle
Takeshi Minashima (845711) +22 more
core +1 more source
, 2017 The overview of microarray analysis work flow (Figure S1) and the list of human housekeeping genes matching with gene array in microarray BeadChip (Table S1). (DOCX 32Â kb)
Thamsermsang, Onusa +3 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source