Results 251 to 260 of about 284,169 (292)

Estradiol-PGC-1 signaling in mitochondrial health: Implications for perimenopause and cardiovascular disease. [PDF]

Physiol Rep
Parten AL, Rowe GC.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Hypoxic Microenvironment Effects on Matrix Metalloproteinases' Expression and Enzymatic Activity, and HIFs' Expression in Non-Small Cell Lung Cancer Cells. [PDF]

Int J Mol Sci
Gonzalez-Avila G, Sandoval C, Sommer B, Garcia-Hernandez AA, Lopez-Gonzalez JS, Aquino-Gálvez A, Becerril C, Flores-Soto E.   +7 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen-Induced Arthritis Rats Through Modulation of the SIRT1/HIF-1α/Glycolysis Pathway. [PDF]

Pharmacol Res Perspect
Zhou Y, Zhou Y, Xiang R, Liu X, Wang T, Chen X, Wang G.   +6 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Cyclic Peptide PROTACs Restore VHL-Mediated HIF-1α Degradation in Hypoxia. [PDF]

J Am Chem Soc
McDermott A, Gardner RM, Papayova M, Wisniewska AB, Doigneaux C, Mohammed S, Tavassoli A.   +6 more
europepmc   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in rd1 mouse inherited retinal degeneration. [PDF]

Cell Death Dis
Wang L, Yan J, Sancho-Pelluz J, Yang Q, Hu Z, Jiao K, Seeliger MW, Paquet-Durand F.   +7 more
europepmc   +1 more source