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Understanding the role of hypoxia inducible factors in liver fibrosis and future therapeutic applications. [PDF]
ILIVERTaimuri Y, Ahmad R.
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KDM2B controls HIF levels and activity through its JmjC and CxxC domains. [PDF]
Biochem JBatie M +6 more
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Myricitrin regulates proliferation, apoptosis and inflammation of chondrocytes treated with IL-1β
Cellular and Molecular Biology, 2020Osteoarthritis (OA) is a clinical disease which seriously affects the quality of life of sufferers. Although the pathogenesis of OA has not been fully unraveled, it is may be due to increased levels of pro-inflammatory cytokines, activation of inflammation-related signaling pathways, and degradation of extracellular matrix.
Tao, Sun +3 more
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Interleukin-1β Inhibits Glutamate Release in Hippocampus of Young, But Not Aged, Rats
Neurobiology of Aging, 1997The proinflammatory cytokine, interleukin-1, is synthesized in neuronal and glial cells and is released in response to stress/injury. IL-1 exerts profound effects on the central nervous system, which include an inhibitory effect on synaptic activity in hippocampus, a brain area expressing a high density of IL-1 receptors.
C A, Murray +3 more
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Prognostic relevance of hypoxia inducible factor-1α expression in patients with melanoma
Clinical and Experimental Dermatology, 2009Overexpression of hypoxia inducible factor (HIF)-1alpha has been found in several human cancers and is thought to correlate with aggressive disease and poor response. A retrospective analysis was carried out on 89 patients with primary cutaneous melanoma.
J, Valencak +7 more
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Unexpected stereocontrolled access to 1α,1′β-disaccharides from methyl 1,2-ortho esters
2015Mannopyranose-derived methyl 1,2-orthoacetates (R = Me) and 1,2-orthobenzoates (R = Ph) undergo stereoselective formation of 1α,1′β-disaccharides, upon treatment with BF 3•Et 2O in CH 2Cl 2, rather than the expected acid-catalyzed reaction leading to methyl glycosides by way of a rearrangement-glycosylation process of the liberated methanol.
Uriel, Clara +4 more
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Neurobiology of Aging, 2001
Transgenic APPV717F mice, homozygous for a human minigene encoding the V717F familial Alzheimer's disease mutation, develop Abeta plaques similar to those seen in Alzheimer patients and show evidence of neuronal cell drop out in CA2-3 regions of the hippocampus at 8 months of age and older. Interleukin-1 (IL-1)beta (IL-1beta) converting enzyme (ICE) is
J G, Sheng +10 more
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Transgenic APPV717F mice, homozygous for a human minigene encoding the V717F familial Alzheimer's disease mutation, develop Abeta plaques similar to those seen in Alzheimer patients and show evidence of neuronal cell drop out in CA2-3 regions of the hippocampus at 8 months of age and older. Interleukin-1 (IL-1)beta (IL-1beta) converting enzyme (ICE) is
J G, Sheng +10 more
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Physical Chemistry Chemical Physics, 2000
The electronic excited state spectrum of platinum monocarbide (PtC) was calculated by a multireference configuration interaction (MRCI) method with and without account of spin-orbit coupling (SOC). It is shown that the previous assignment of the red bands (700–880 nm) in the PtC spectrum should be changed from the singlet–singlet transitions A′ 1Π–X 1Σ+
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The electronic excited state spectrum of platinum monocarbide (PtC) was calculated by a multireference configuration interaction (MRCI) method with and without account of spin-orbit coupling (SOC). It is shown that the previous assignment of the red bands (700–880 nm) in the PtC spectrum should be changed from the singlet–singlet transitions A′ 1Π–X 1Σ+
openaire +1 more source