Results 261 to 270 of about 284,169 (292)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Taselisib, a PI3K Inhibitor, Alleviates Neuropathic Pain through HIF-1α-Mediated Angiogenesis in a Rat Model of Chronic Constriction Injury.

Neuroimmunomodulation
You HP, Zhang LH, Li CY, He HF, Chen ZY, Wang HG, Liu WF, Xu CJ.   +7 more
europepmc   +1 more source

Analysis of hypoxia-inducible factors in the deep-sea fish reveals genetic adaptation to hypoxic environments. [PDF]

Zool Res
Ai G, Fang WY, Song YN, Xu H, Li T, Hu RT, Wang J, Xiao WH, He LS, Gan XN, He SP.   +10 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Hypoxia-Inducible Factor 1α in the Aortic Wall: Protective Adaptation or Marker of a Vulnerable Phenotype? [PDF]

FASEB J
Grewal N.
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

The Role of Glycolysis in Diabetic Kidney Disease. [PDF]

Int J Mol Sci
Wang Y, Jiang X, Cui L, You Y, Zhu W, Jiang C, Liao Z, Guo J, Lu H, Shao B, Luo X, Pai P, Chen H.   +12 more
europepmc   +1 more source

High-altitude gastric disorders: insights into maladaptation pathophysiological mechanisms, disease spectrum and prevention strategies. [PDF]

Front Physiol
Shang H, Zhang R, Xie Y, Yang A, Wang J.
europepmc   +1 more source

ANGII Initiated HSF2 Trans-Activating HIF-1α Through Induction of ER Stress to Promote Cardiac Hypertrophy. [PDF]

Clin Exp Pharmacol Physiol
Cao R, Meng Q, Li G, Yuan S, Li C, Zhao X, Zhang D.   +6 more
europepmc   +1 more source

Concerns Regarding Evidence for the AMPK/PGC-1α/Mfn2 Axis and Mitochondria-ER Dysfunction in a Rat Model of Myofascial Trigger Points [Letter]. [PDF]

J Pain Res
Chen L, Guo X.
europepmc   +1 more source