Results 41 to 50 of about 284,169 (292)

Synergistic inhibition of Wnt pathway by HIF-1α and osteoblast-specific transcription factor osterix (Osx) in osteoblasts. [PDF]

PLoS ONE, 2012
Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation. Inhibition of Wnt pathway by Osx highlights the potential for feedback control mechanisms involved in bone formation.
Dafu Chen, Yang Li, Zhiyu Zhou, Yonggang Xing, Yu Zhong, Xuenong Zou, Wei Tian, Chi Zhang   +7 more
doaj   +1 more source

Characterization of CPH:SA microparticle‐based delivery of interleukin‐1 alpha for cancer immunotherapy

Bioengineering & Translational Medicine, 2023
Background Interleukin‐1 alpha (IL‐1α) is a pro‐inflammatory cytokine that can activate immune effector cells and trigger anti‐tumor immune responses. However, dose‐limiting toxicities including cytokine storm and hypotension has limited its use in the ...
M. M. Hasibuzzaman, Rui He, Ishrat Nourin Khan, Rasna Sabharwal, Aliasger K. Salem, Andrean Llewela Simons‐Burnett   +5 more
doaj   +1 more source

Effects of interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α ) on dopamine of the cerebral palsy

Asian Journal of Tropical Biotechnology, 2004
The caused of disability on cerebral palsy is unknown, but the human cerebral hypoxic, which affected to the motor cortex and motor pathways in the brain is believed cause of it. The major clinical manifestations are abnormality of movements and posture patterns. The immunity against the cerebral palsy (CP) is unknown, but interleukine-1β (IL-1β) and
openaire   +1 more source

Effect of HIF-1αsiRNA-linked AuNRs on radiotherapy of nasopharyngeal carcinoma

Cellular and Molecular Biology, 2020
The radiation sensitivity of tumor cells is closely related to tumor cell hypoxia. Hypoxia-inducible factor-1α (HIF-1α) is considered a key transcription factor which regulates the sensitivity of hypoxic tumor cells to radiotherapy. On the other hand, some studies have shown that gold nanomaterials improve radiation sensitivity.
Gang, Xu, Haosheng, Zhang, Zhibin, Li, Shihai, Wu, Rencui, Quan, Kun, Mao, Yang, Sheng, Xianming, Li   +7 more
openaire   +3 more sources

NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo

Journal of Lipid Research, 2018
Transcriptional coactivator PPAR γ coactivator (PGC)-1α and its splice variant N-terminal (NT)-PGC-1α mediate transcriptional regulation of brown adipose tissue (BAT) thermogenesis in response to changes in ambient temperature.
Jihyun Kim, Min Sung Park, Kyoungsoo Ha, Chulhong Park, Jisu Lee, Randall L. Mynatt, Ji Suk Chang   +6 more
doaj   +1 more source

Cholesterol and HIF-1α: Dangerous Liaisons in Atherosclerosis

Frontiers in Immunology, 2022
HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque, experimental models of atherosclerosis suggest a more complex role that depends on the ...
Charles Thomas, Charles Thomas, Charles Thomas, Damien Leleu, Damien Leleu, Damien Leleu, Damien Leleu, David Masson, David Masson, David Masson, David Masson   +10 more
doaj   +1 more source

Alteration of dopamine, homovanillic acid (HVA) with interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cerebral palsy

Biodiversitas Journal of Biological Diversity, 1970
Now, diagnosis of cerebral palsy base only on clinical finding without involve the alteration of the neurochemistry cause by cerebral hypoxic, although cerebral palsy is a syndrome cause by cerebral hypoxic; so, the accuracy diagnosis of this disease is very low.
openaire   +2 more sources

Peran Magnesium Sulfat dalam Menurunkan Kadar TNF-α dan IL-1β pada Bayi Prematur

Jurnal Kedokteran Brawijaya, 2017
Prematuritas menyebabkan mortalitas dan morbiditas neonatus yaitu cerebral palsy (CP), gangguan kognitif dan gangguan tingkah laku. Sitokin proinflamasi TNF-α dan IL-1β diduga secara signifikan meningkat pada bayi prematur. Magnesium sulfat (MgSO4) diduga dapat sebagai neuroprotektor terhadap otak janin, melindungi jaringan terhadap aktivitas radikal
Sri Sulistyowati, Ferri Waluyo Wiwoho Pujojati, Supriyadi Hari Respati, Soetrisno - -   +3 more
openaire   +2 more sources

HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. [PDF]

PLoS ONE, 2013
The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia.
Dafu Chen, Yang Li, Zhiyu Zhou, Chengai Wu, Yonggang Xing, Xuenong Zou, Wei Tian, Chi Zhang   +7 more
doaj   +1 more source

Ultrasound‐targeted cationic microbubbles combined with the NFκB binding motif increase SDF‐1α gene transfection: A protective role in hearts after myocardial infarction

Kaohsiung Journal of Medical Sciences, 2022
Treatment of myocardial infarction (MI) remains a major challenge. The chemokine family plays an important role in cardiac injury, repair, and remodeling following MI, while stromal cell‐derived factor‐1 alpha (SDF‐1α) is the most promising therapeutic ...
Cai‐Gui Yu, Qing Deng, Sheng Cao, Zhi‐Yu Zhao, Dan‐E Mei, Chuang‐Li Feng, Qing Zhou, Jin‐Ling Chen   +7 more
doaj   +1 more source