Results 21 to 30 of about 284,169 (292)

The impact of vitamin D in breast cancer: genomics, pathways, metabolism

Frontiers in Physiology, 2014
Nuclear receptors exert profound effects on mammary gland physiology and have complex roles in the etiology of breast cancer. In addition to receptors for classic steroid hormones such as estrogen and progesterone, the nuclear vitamin D receptor (VDR ...
Carmen Judith Narvaez, Donald eMatthews, Donald eMatthews, Erika eLaPorta, Erika eLaPorta, Katrina Marie Simmons, Katrina Marie Simmons, Sarah eBeaudin, Sarah eBeaudin, JoEllen eWelsh   +9 more
doaj   +1 more source

The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia

Andalas Obstetrics And Gynecology Journal, 2021
The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M.
David Perdana, Defrin Defrin, Firdawati Firdawati   +2 more
openaire   +2 more sources

Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice. [PDF]

PLoS ONE, 2011
Proinflammatory cytokines secreted from adipose tissue contribute to the morbidity associated with obesity. IL-1α is one of the proinflammatory cytokines; however, it has not been clarified whether IL-1α may also cause obesity.
Jae-Young Um, Hong-Kun Rim, Su-Jin Kim, Hye-Lin Kim, Seung-Heon Hong   +4 more
doaj   +1 more source

PGC-1α and Myokines in the aging muscle : a mini-review [PDF]

, 2011
Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly ...
Egger, A., Handschin, C., Arnold, A. -S., Arnold AS, Handschin C, Egger A   +5 more
core   +1 more source

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]

, 2014
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M, Carles Galdeano (1305135), Galdeano, Carles, Dias, David M., David M. Dias (1340694), Van Molle, Inge, Gadd, Morgan Stuart, Ciulli, Alessio, Sarah Hewitt (1340700), Soares, Pedro, Galdeano , Carles, Pedro Soares (393566), Gadd, Morgan S., Salvatore Scaffidi (1340703), Inge Van Molle (1284120), Morgan S. Gadd (149371), Scaffidi, Salvatore, Ipek Birced (1340697), Alessio Ciulli (762789), Hewitt, Sarah, Birced, Ipek   +20 more
core   +1 more source

PGC-1α modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior [PDF]

, 2014
The benefits of exercise on wellbeing have been known to mankind for thousands of years, yet the underlying mechanisms of exercise have been explained only relatively recently.
Dinulović, Ivana
core   +1 more source

The expression of TNF-α, IL-1β, and IL-10 in the diabetes mellitus condition induced by the combination of spirulina and chitosan

Bali Medical Journal, 2020
Background: Rapid wound healing is needed after tooth extraction treatment so that prosthodontics treatment can be done immediately. However, systemic diseases, such as diabetes mellitus, can inhibit the wound healing process. The state of hyperglycemia in people with diabetes mellitus can interfere with the function of macrophages and neutrophils ...
Nike Hendrijantini, -, Ratri Maya Sitalaksmi, -, Muhammad Dimas Aditya Ari, -, Tiffany Josephine Hidayat, -, Prisca Agustina Nurcahyani Putri, -, Daniel Sukandar, -   +5 more
openaire   +1 more source

Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α [PDF]

, 2005
Inducible hepatic porphyrias are inherited genetic disorders of enzymes of heme biosynthesis. The main clinical manifestations are acute attacks of neuropsychiatric symptoms frequently precipitated by drugs, hormones, or fasting, associated with ...
Lin, J., Handschin, Christoph, Rhee, James, Peyer, Anne-Kathrin, Meyer, Urs A, Handschin, C., Spiegelman, Bruce M, Meyer, U. A., Lin, Jiandie, Rhee, J., Wu, P. -H., Peyer, A. -K., Chin, Sherry, Spiegelman, B. M., Chin, S., Wu, Pei-Hsuan   +15 more
core   +1 more source

Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary

Frontiers in Physiology, 2018
There is an increasing recognition that vitamin D plays important roles in female reproduction. Recent studies demonstrated that 1α,25-dihydroxyvitamin D3 (VD3), the biologically active form of vitamin D, improved ovarian follicle survival and growth in ...
Jing Xu, Jing Xu, Maralee S. Lawson, Fuhua Xu, Yongrui Du, Yongrui Du, Olena Y. Tkachenko, Cecily V. Bishop, Lucas Pejovic-Nezhat, David B. Seifer, Jon D. Hennebold, Jon D. Hennebold   +11 more
doaj   +1 more source

HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model. [PDF]

PLoS ONE, 2012
BACKGROUND: Hypoxia-inducible factor 1α (HIF-1α) is an important regulator of immune and inflammatory responses. We hypothesized that nasal allergic inflammation is attenuated by HIF-1α inhibition and strengthened by HIF-1α stabilization.
Han Zhou, Xi Chen, Wei-Ming Zhang, Lu-Ping Zhu, Lei Cheng   +4 more
doaj   +1 more source