Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism [PDF]
PPAR Research, 2012 Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα,
Hee-Jin Jun +2 more
doaj +2 more sources
IL-1α Processing, Signaling and Its Role in Cancer Progression
Cells, 2021 Interleukin-1α (IL-1α) is a major alarmin cytokine which triggers and boosts the inflammatory responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been extensively studied and emerged as a vital regulator in ...
Jing Wen Chiu +4 more
doaj +2 more sources
Molecular characterization of mudskipper (Boleophthalmus pectinirostris) hypoxia-inducible factor-1α (HIF-1α) and analysis of its function in monocytes/macrophages. [PDF]
PLoS ONE, 2017 Hypoxia-inducible factor-1α (HIF-1α) plays a critical role in immune and inflammatory responses and is important in controlling a variety of processes in monocytes and macrophages.
Feng Guan +3 more
doaj +2 more sources
Quercetin and Quercetin-Rich Red Onion Extract Alter Pgc-1α Promoter Methylation and Splice Variant Expression [PDF]
PPAR Research, 2017 Pgc-1α and its various isoforms may play a role in determining skeletal muscle mitochondrial adaptations in response to diet. 8 wks of dietary supplementation with the flavonoid quercetin (Q) or red onion extract (ROE) in a high fat diet (HFD ...
Prasad P. Devarshi +4 more
doaj +2 more sources
The Hypoxia-Inducible Factor-1α Signaling Pathway and its Relation to Cancer and Immunology [PDF]
American Journal of Immunology, 2014 Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the
Bruno R.B. Pires +5 more
openaire +1 more source
Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women
Bali Medical Journal, 2021 Background: The aging process is associated with an increase in proinflammatory markers' serum levels, indicating that a chronic inflammatory process is correlated with an increase in disability, mortality, and frailty. Pro-inflammatory cytokines that increase with the incidence of frailty syndrome are IL-6, IL-1β and TNF-α.
Dwi Ngestiningsih +2 more
openaire +1 more source
Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1
OncoImmunology, 2022 Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. Many tumors have increased IL-1α expression. However, the immune regulatory role of secreted IL-1α in tumor development and whether it can be targeted for cancer therapy ...
Dandan Lin +11 more
doaj +1 more source
Hypoxia-Inducible Factor 1α Expression in Chorionic Tissue and Decidua of Women with Spontaneous Abortion at the First Trimester of Pregnancy [PDF]
American Journal of Biochemistry and Biotechnology, 2014 Oxygen-regulated genes expression has important role in pre-implantation embryonic metabolism regulation. Hypoxia Inducible Factor (HIF) regulated by hypoxia oxygen tension is crucial for placenta development. But the data about its role in spontaneous abortion is very poor. Thus, we aimed to determine an expression level of HIF-1I± in chorionic tissue
E. V. Mashkina +2 more
openaire +1 more source
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α [PDF]
, 2007 Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake, fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these pathways.
B. M. Spiegelman +7 more
core +1 more source
Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]
, 2015 Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Handschin, Christoph +7 more
core +1 more source