Results 71 to 80 of about 284,169 (292)

HIF-1α protects against oxidative stress by directly targeting mitochondria

Redox Biology, 2019
The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression.
Hong-Sheng Li, Yan-Ni Zhou, Lu Li, Sheng-Fu Li, Dan Long, Xue-Lu Chen, Jia-Bi Zhang, Li Feng, You-Ping Li   +8 more
doaj   +1 more source

Characterization of the autocrine/paracrine function of vitamin D in human gingival fibroblasts and periodontal ligament cells. [PDF]

PLoS ONE, 2012
BACKGROUND: We previously demonstrated that 25-hydroxyvitamin D(3), the precursor of 1α,25-dihydroxyvitamin D(3), is abundant around periodontal soft tissues.
Kaining Liu, Huanxin Meng, Jianxia Hou
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Hypoxia-inducible factor-1α as a biomarker for individuals under hypoxia duration and pattern in fat greenling Hexagrammos otakii

Aquaculture Reports
Background: One common environmental stressor in fisheries is hypoxia stress, which frequently causes significant fish mortality and financial losses. This study aimed to examine the potential utility of serum concentrations of hypoxia-inducible factor ...
Yu Zhan, Xin Qi, Yiting Wu, Dongxu Gao, Ling Zhao, Shengnan Cao, Zhuang Xue, Wei Wang   +7 more
doaj   +1 more source

Hyperuricemia and Pro Inflammatory Cytokine (IL-1β, IL-6, and TNF-α)

Indonesian Journal of Rheumatology, 2018
Background. Rugerio et al 2006 reported that there were a positive correlation between the level of hyperuricemia and the level of IL-1β, IL-6, and TNF-α pro infl ammatory cytokines value. On the other hand, Choi et al reported a negative correlation between hyperuricemia and the level of pro infl ammatory cytokine in the late phase of hyperuricemia.
Suyanto Hadi, D Sudarsono, Bantar Suntoko   +2 more
openaire   +1 more source

The In Situ Expression of IL-6 and IL-1? in breast cancer patients

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), 2017
Breast cancer is the second most common cancer in women world. Multiple Cytokines appear to have a dominant role in human breast cancer formation. Estimation of the in situ expression of  IL-6 and IL-1β in breast cancer patients. A sixty patients with breast cancer BC were divided into two clinical subgroups, (30) with malignant breast cancer MBC and (
Amal H. Salman, Mayada N. Iqbal, Wasan A. Bakir   +2 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

NleB interacts with HIF-1α.

, 2018
(A) HIF-1α co-localized with NleB in HeLa cells and HCT116 cells. HeLa cells and HCT116 cells were transfected with GFP-tagged HIF-1α (GFP-HIF-1α) together with RFP-tagged NleB and then examined by a Zeiss confocal microscope (LSM-710).
Huangyuan Zha (5646368), Xing Liu (221084), Wuhan Xiao (206571), Chenxi Xu (2880902), Dawei Zhang (58801), Sijia Fan (5646371), Shan Li (110392)   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs

Brazilian Journal of Medical and Biological Research, 2012
Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenviroment.
Zeng Dong-Feng, Liu Ting, Chang Cheng, Zhang Xi, Liang Xue, Chen Xing-Hua, Kong Pei-Yan   +6 more
doaj   +1 more source