Results 81 to 90 of about 284,169 (292)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Crosstalk between FGF2 and HIF-1α.

, 2013
A. FGF2 and HIF-1α gene silencing using targeted-siRNA. 911 cells were transfected with FGF2 (left) or HIF-1α (right) targeted siRNA (siFGF2 or siHIF-1α, respectively).
Céline Toutain (88345), Elodie Riant (88344), Françoise Pujol (88346), Jean-François Arnal (83695), Françoise Lenfant (88347), Caroline Conte (88343), Anne-Catherine Prats (4523)   +6 more
core   +1 more source

Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis [PDF]

, 2013
Chronic inflammation is a fundamental aspect of metabolic disorders such as obesity, diabetes and cardiovascular disease. Cholesterol crystals are metabolic signals that trigger sterile inflammation in atherosclerosis, presumably by activating ...
Kopf, Manfred, Kanneganti, Thirumala-Devi, Ampenberger, Franziska, Freigang, Stefan, Weiss, Adrienne, Iwakura, Yoichiro, Freigang, Stefan Bernd, Hersberger, Martin, Hersberger, Martin; https://orcid.org/, Weiss A, Kopf M, Iwakura Y, Kanneganti TD, Freigang S, Ampenberger F, Hersberger M   +15 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α. [PDF]

PLoS ONE, 2016
The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation.
Jihyun Kim, Vivian E Fernand, Tara M Henagan, Jeho Shin, Peter Huypens, Susan Newman, Thomas W Gettys, Ji Suk Chang   +7 more
doaj   +1 more source

Specificity of HIF-1α dependent activation of the DDX3 gene.

, 2013
Stable MCF 10A and MCF 7-HIF-1α shRNA clones were generated. (a) MCF 10A-shHIF-1α and (b) MCF 7-shHIF-1α cells were subjected to 200 µM CoCl2 for the indicated times. qRT-PCR analysis was performed using specific primers for human DDX3, HIF-1α and HIF-2α.
Balaji Krishnamachary (309844), Arvind H. Patel (33806), Paul T. Winnard Jr. (354373), Mahendran Botlagunta (354370), Guus M. Bol (354375), Venu Raman (309847), Farhad Vesuna (354371)   +6 more
core   +1 more source

Regulation of glycolysis in brown adipocytes by HIF-1α [PDF]

, 2017
Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold ...
Basse, Astrid Linde, Winther, Sally, Bjørn Quistorff, Christian Wolfrum, Sally Winther, Maria Murholm, Marie S. Isidor, Pedersen, Steen B., Isidor, Marie S., Andersen, Elise S., Hansen, Jacob B., Steen B. Pedersen, Quistorff, Bjørn, Isidor, Marie Sophie, Elise S. Andersen, Wolfrum, Christian, Jacob B. Hansen, Skjoldborg, Nina B., Basse, Astrid L., Quistorff, Bjorn, Murholm, Maria, Astrid L. Basse, Nina B. Skjoldborg, Hansen JB, Basse AL, Quistorff B, Murholm M, Skjoldborg NB, Andersen ES, Pedersen SB, Wolfrum C, Isidor MS, Winther S   +32 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

MOESM3 of Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

, 2019
Additional file 3. Flowchart of the extraction and isolation of oligostilbenes from Paeonia suffruticosa seed. 1 suffruticosol A, 2 suffruticosol B, 3 suffruticosol C, 4 trans-resveratrol, 5 cis-Îľ-viniferin, 6 trans-Îľ-viniferin, 7 cis-suffruticosol D, 8 cis-gnetin H, 9 trans-suffruticosol D, and 10 trans-gnetin H.
He, Yu-Kun, Cen, Xiao-tong, Liu, Shuang-shuang, Lu, Hua-ding, He, Chun-nian   +4 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source