Results 101 to 110 of about 284,169 (292)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj   +1 more source

Immunohistological and western blot analyses of HIF-1α.

, 2016
(A) PAB liver stained by HIF-1α (original magnification, ×20). (B) Sham-operated control liver stained by HIF-1α (original magnification, ×20). (C) Enlarged view of the boxed area in the Image (A) (original magnification, ×100). (D) Western blot analysis
Sadataka Kawachi (849638), Yoichiro Kusakari (849641), Yoshitaka Fujimoto (849634), Toru Akaike (849640), Hiroyuki Ida (849644), Daisuke Shimura (849636), Reiji Ito (849637), Nobuhito Goda (707134), Kiyoshi Ogawa (849643), Susumu Minamisawa (324230), Masako Fujiwara (849642), Takashi Urashima (849635), Ichige Kajimura (849639)   +12 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Hepatic Hypoxia-Inducible Factor 1α Mediates Ferroptosis via Transferrin Receptor 1 in Acute Liver Injury

Antioxidants
Acute liver injury (ALI) is a potentially life-threatening condition lacking effective clinical drugs. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of both inflammation and metabolism.
Jiayu Yang, Meicheng Wang, Shichao Cui, Yulan Xia, Yinfang Xie, Zhu Hu, Ni Li, Xinwen Zhang, Pengfei Zhu, Xu Yu, Linshi Wu, Jingya Li   +11 more
doaj   +1 more source

Exploring the Glucocorticoid Actions of 1α-Hydroxycorticosterone (1α-OH-B) in the Elasmobranch Fishes [PDF]

, 2014
The corticosteroid 1α-hydroxycorticosterone (1α-OH-B) is unique to the elasmobranch fishes. It is thought that 1α-OH-B acts as both the primary glucocorticoid (GC) and mineralocorticoid (MC) in these fishes, a dual role analogous to that of cortisol in ...
Lambert, Faith Nichole
core  

The effect of NT-PGC-1α on candidate gene expression in brown adipocytes.

, 2016
(A) Schematic diagram of splicing events of the PGC-1α gene. Splicing between canonical exon 1a and exon 2 produces PGC-1α-a and NT-PGC-1α-a, whereas alternative splicing between distal exon 1b and exon 2 produces PGC-1α-b and NT-PGC-1α-b.
Tara M. Henagan (525690), Peter Huypens (2889101), Thomas W. Gettys (525692), Susan Newman (247025), Vivian E. Fernand (1894828), Jihyun Kim (79184), Jeho Shin (2889107), Ji Suk Chang (2889104)   +7 more
core   +1 more source

Additional file 1: of HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

, 2018
Table S1. Primers list used for quantitative real-time PCR analysis of different genes. Figure S1. Confirmation of HSP60 knockdown by vivo morpholino in mice brain. Figure S2. The overexpression of HSP60 was confirmed by Western blot. Figure S3. JEV induces inflammation in N9 murine microglial cells at MOI 2. (DOCX 1066 kb)
Swaroop, Shalini, Mahadevan, Anita, Shankar, Susarla, Adlakha, Yogita, Basu, Anirban   +4 more
openaire   +1 more source

Studying the C1772T polymorphism of Hif-1α and TGF-β3 IVS5+104 A/G polymorphism in children with congenital non-syndromic neural tube defects and their mothers

Cellular and Molecular Biology, 2018
Prevalence of neural tube defect (NTD) has reduced after folic acid intake. However; which mechanisms are effective in NTD are not known exactly. In this study; due to the possible effects on hypoxic pathway and embryonic development, particularly on extracellular matrix components, Hif-1α Pro582Ser and TGF-β3 IVS5+104 A/G SfaN1 polymorphisms were ...
ć°brahim Halil Yildirim, Nadir Koçak
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source