Results 121 to 130 of about 284,169 (292)

Expression significance and potential mechanism of hypoxia‐inducible factor 1 alpha in patients with myelodysplastic syndromes

Cancer Medicine, 2019
Objective To investigate the expression level and potential mechanism of hypoxia‐inducible factor 1 alpha (HIF‐1α) in patients with myelodysplastic syndromes (MDS). Methods Immunohistochemistry (IHC) techniques were used to examine the protein expression
Hai‐wei Liang, Bin Luo, Li‐hua Du, Rong‐quan He, Gang Chen, Zhi‐gang Peng, Jie Ma   +6 more
doaj   +1 more source

MiR199b Suppresses Expression of Hypoxia-Inducible Factor 1α (HIF-1α) in Prostate Cancer Cells

, 2013
MicroRNAs (miRNAs) are a class of small noncoding RNAs that post-transcriptionally repress expression of target genes via imperfect base-pairing with the 3\u27-untranslated region (3\u27-UTR). The transcription factor hypoxia-inducible factor-1α (HIF-1α)
Miao Xu, Ni Chen, Hao Zeng, Ling Nie, Qiao Zhou, Xueqin Chen, Weiwei Shang   +6 more
core   +1 more source

Additional file 2: Table S1. of IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

, 2018
Commercially available primer sequences for genes analysed with RT-qPCR. (DOCX 13 kb)
Mahmutovic Persson, Irma, Menzel, Mandy, Ramu, Sangeetha, Cerps, Samuel, Akbarshahi, Hamid, Uller, Lena   +5 more
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

High Hypoxia Inducible Factor-1α Expression and Positive Limphovascular Invasion as Risk Factors for Axillary Lymph Nodes Metastasis in Breast Cancer

Indonesian Journal of Cancer
Background: Hypoxia-inducible factor-1α (HIF-1α) expression enables tumor cell proliferation and has a role in the processes of epithelial-mesenchymal transition, invasion, extravasation, and metastasis. Lymphovascular Invasion (LVI) causes a significant increase in the occurrence of axilla lymph node metastasis.
I Gede Budhi Setiawan, Made Agus Suanjaya, IB Made Suryawisesa   +2 more
openaire   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Additional file 1: Figure S1. of Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

, 2017
Global gene expression patterns in hiChondrocytes and juvenile chondrocytes are distinct from adult chondrocytes: (a) scheme for a step-wise hiChondrocyte differentiation from hiPSC using defined growth factors, (b) cell proliferation kinetics of hiChondrocytes, adult chondrocytes, and juvenile chondrocytes over 24, 48, and 96 hours, (c)heatmap ...
Lee, Jieun, Smeriglio, Piera, Chu, Constance, Bhutani, Nidhi   +3 more
openaire   +1 more source