Results 111 to 120 of about 284,169 (292)
PIN1 enhances the stability of HIF-1α.
, 2016 A) Lysates of cells were transfected with DNA-based siRNA expression vectors for 72 h, then exposed to hypoxia for 4 h, and then treated with CHX (10 μM) for the indicated time periods under hypoxic condition were used for Western blotting analysis with ...
Nayoung Kwon (846567) +13 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
Molecular Metabolism, 2018 Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1.
Jaemin Lee +5 more
doaj +1 more source
The FASEB Journal, 2011 Northern elephant seals ( Mirounga angustirostris ) are naturally adapted to prolonged periods (1–3 months) of food deprivation (fasting) and tissue ischemia. Fasting elephant seal pups do not exhibit signs of oxidative damage or inflammation despite increases in the renin‐angiotensin system,
Jose Guadalupe Sonanez Organis +5 more
openaire +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes
BMC Pharmacology and Toxicology, 2019 Background Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD).
Hao Huang +10 more
doaj +1 more source
, 2010 口腔癌的排名有逐年上升的趨勢，年增率高居癌症第一位，死亡率過半。癌症治療的方式多樣化，目地在延長病患壽命，甚至進一步治癒癌症。以手術切除常因造成顏面傷殘及病患心理壓力而放棄，為尋求減少侵犯性治療，進行新興的光動力治療。光動力治療(Photodynamic therapy, PDT)是新興的癌症治療的方式，光動力治療已運用在其它不易手術部位的癌療。光動力治療的藥物也有進一步的改善，先前我們採用新研發的二代光感藥物(photosensitizer) 5-氨基酮戊酸(5-aminolevulinic acid,
曾建福, Tseng, Chien-Fu
core
A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
, 2018 Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT).
Sujoy Ghosh +3 more
core +1 more source
Jurnal Kedokteran Brawijaya, 2013  Anemia merupakan faktor prognostik independen untuk pertahanan hidup pasien kanker. Penurunan kapasitas oksigen pada darah dapat menyebabkan terjadinya kondisi hipoksia pada jaringan kanker . Hipoksia pada jaringan kanker dapat mengaktivasi faktor transkripsi hypoxia-inducible factor-1α (HIF-1α) yang kemudian akan mentranskripsi banyak gen lain ...
Muhammad Darwin P +4 more
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source