Results 91 to 100 of about 284,169 (292)

HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

World Journal of Surgical Oncology, 2020
Background The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear.
Yuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada, Mitsuo Shimada   +7 more
doaj   +1 more source

1, 9 PA enhances HIF-1α ubiquitination.

, 2013
(A). A431 cells were treated with 10 µM 1, 9 PA for indicated time period. Cell lysates were prepared for HIF-1α immunoprecipitation, followed by Western blotting of the immunoprecipitates with antibodies directed against ubiquitin (top), HIF-1α, and β ...
Yang Lu (59885), Zhen Fan (59888), Haiquan Lu (358224), Xinqun Li (59884)   +3 more
core   +1 more source

MOESM6 of Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

, 2019
Additional file 6. Immunofluorescence of Collagen II to identify primary chondrocytes. The Collagen Type II Antibody (Proteintech, USA) was used as the primary antibody. After the chondrocytes were incubated with goat anti-mouse immunoglobulin Alexa Fluor Plus 594 (1:200 dilution), they were stained red. The nuclei were stained with DAPI. After merging
He, Yu-Kun, Cen, Xiao-tong, Liu, Shuang-shuang, Lu, Hua-ding, He, Chun-nian   +4 more
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Analysis of HIF-1α-expression.

, 2015
Protein analysis for HIF-1α shows significant increase of HIF-1α-expression in hippocampal tissue 6h after SAH (A+B) independent from type of technique (Location of ICP-probe is hallmarked (+)).
Anke Höllig (721267), Rolf Rossaint (237), Agnieszka Weinandy (721268), Mark Coburn (173161), Hans Clusmann (721270), Kay Nolte (721269)   +5 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Heme oxygenase metabolites improve astrocytic mitochondrial function via a Ca2+-dependent HIF-1α/ERRα circuit.

PLoS ONE, 2018
Heme oxygenase-1 (HO-1) exerts beneficial effects, including angiogenesis and energy metabolism via the hypoxia-inducible factor-1α (HIF-1α) and peroxisome-proliferator-activating receptor-γ coactivator-1α (PGC-1α)/estrogen-related receptor α (ERRα ...
Yoon Kyung Choi, Joon Ha Park, Jung-A Yun, Jong-Ho Cha, Yonghee Kim, Moo-Ho Won, Kyu-Won Kim, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim   +9 more
doaj   +1 more source

Inactivation of Foxo3a and subsequent downregulation of PGC-1α mediate nitric oxide-induced endothelial cell migration

, 2010
In damaged or proliferating endothelium, production of nitric oxide (NO) from endothelial nitric oxide synthase (eNOS) is associated with elevated levels of reactive oxygen species (ROS), which are necessary for endothelial migration.
García Quintáns, Nieves, Borniquel, Sara, Lamas, Santiago, García-Quintans, Nieves, Nieves García-Quintáns, Olmos, Yolanda, Wild, Brigitte, Santiago Lamas, Brigitte Wild, Olmos Buchelt, Yolanda, Soria, Estrella, Martínez-Granero, Francisco, Lamas Peláez, Santiago, Sara Borniquel, Yolanda Olmos, Estrella Soria, María Monsalve, Martínez Granero, Francisco, Inmaculada Valle, Valle, Inmaculada, Monsalve, María, Francisco Martínez-Granero   +21 more
core   +1 more source

Additional file 1: of Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migration

, 2018
Table S1. Sequences of primers used for quantitative real-time polymerase chain reaction experiments. (DOCX 12 kb)
Guo, Yu-Chien, Chiu, Yun-Hsuan, Chen, Chie-Pein, Wang, Hwai-Shi   +3 more
openaire   +1 more source