Results 211 to 220 of about 362,273 (289)

Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling. [PDF]

J Biol Chem
Ghosh C, Kakar R, Bavuso M, Wang H, Sun Y.   +4 more
europepmc   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

PI3K-Seeker: A Machine Learning-Powered Web Tool to Discover PI3K Inhibitors. [PDF]

ACS Omega
de Sousa FJF, Antunes DA, Zanatta G.
europepmc   +1 more source

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic β cells through activation of phosphatidylinositol 4-kinase β

, 2005
J. Gromada, C. Bark, K. Smidt, Alexander M. Efanov, J. Janson, S. Mandic, D. Webb, Wei Zhang, B. Meister, A. Jeromin, P. Berggren   +10 more
semanticscholar   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

PTPN18 functions as a tumor suppressor in breast cancer by negatively regulating cyclin E. [PDF]

Int J Oncol
Zhang N, Wang T, Bai B, Zhang X, Xu W, Chen W, Yu Y, Wang B.   +7 more
europepmc   +1 more source

Phosphatidylinositol 4-Kinase Activation Is an Early Response to Salicylic Acid in Arabidopsis Suspension Cells1[W]

Plant Physiology, 2007
Ondřej Krinke, E. Ruelland, O. Valentová, C. Vergnolle, J. Renou, L. Taconnat, Matyáš Flemr, L. Burketová, A. Zachowski   +8 more
semanticscholar   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

Network pharmacology and molecular docking analysis of Yishenqingzhuo oral liquid for chronic kidney disease. [PDF]

Medicine (Baltimore)
Zhao A, Qiu Y, Chen B, Dai S, Zhang W.
europepmc   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, EarlyView.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source