Results 251 to 260 of about 362,273 (289)

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

<i>RSPO3</i> rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. [PDF]

World J Gastrointest Oncol
Tur R, Abad M, Filipovich E, Rivas MB, Rodriguez M, Montero JC, Sayagués JM.   +6 more
europepmc   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Golgi-localized phosphatidylinositol 4-kinase β mediates Rab11a activation and trafficking to promote ciliogenesis. [PDF]

Sci Adv
Wang L, Sun J, Sun S, Huang Z, Liu Y, Yan S, Sun C, Feng Q, Fu W, Zhong T, Zhang J, Zhou J, Liu P.   +12 more
europepmc   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

<i>RGS4</i> in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. [PDF]

World J Gastroenterol
Yang Y, Chen WM.
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Role of hsa-miR-122-5p in chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease: Targeting PIK3CG in the PI3K/Akt signaling pathway. [PDF]

Medicine (Baltimore)
Chen R, Ye W, Yang Y, Liao H, Sun T, Liao W, Li H, Li K, Chen M, Cheng J, Zheng Z, Yao W.   +11 more
europepmc   +1 more source

Myosin 7a is required for maintaining the transducing stereocilia and for force transmission to the MET channel during cochlear hair cell development

The Journal of Physiology, EarlyView.
Abstract figure legend Developmental changes in the hair‐bundle structure of outer hair cells (OHCs) and inner hair cells (IHCs) were examined in control and shaker‐1 mutant (Myo7aSh1/Sh1) mice, which carry a spontaneous missense mutation in the Myo7a gene that produces a non‐functional MYO7A protein.
Anna Underhill, Samuel Webb, Fiorella C. Grandi, Adam J. Carlton, Jing‐Yi Jeng, Stuart L. Johnson, Corné J. Kros, Walter Marcotti   +7 more
wiley   +1 more source

Protective effects of naringenin and naringin in organ ischemia/reperfusion injuries: a comprehensive narrative review. [PDF]

Front Pharmacol
Hou M, Wei D, Wang Y, Zhang X, Yao Z.
europepmc   +1 more source